We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q5ZJX1 (AB17C_CHICK)
Protein
Alpha/beta hydrolase domain-containing protein 17C
Gene
ABHD17C
Organism
Gallus gallus (Chicken)
Status
Functioni
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS.
By similarityCatalytic activityi
- H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H+ + hexadecanoate + L-cysteinyl-[protein]By similarityEC:3.1.2.22By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 192 | Charge relay systemBy similarity | 1 | |
Active sitei | 257 | Charge relay systemBy similarity | 1 | |
Active sitei | 286 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- palmitoyl-(protein) hydrolase activity Source: GO_Central
GO - Biological processi
- negative regulation of protein localization to microtubule Source: Ensembl
- positive regulation of protein localization to endosome Source: Ensembl
- protein depalmitoylation Source: GO_Central
- regulation of postsynapse organization Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
Reactomei | R-GGA-9648002, RAS processing |
Protein family/group databases
MEROPSi | S09.053 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha/beta hydrolase domain-containing protein 17CCurated (EC:3.1.2.22By similarity)Short name: Abhydrolase domain-containing protein 17CBy similarity |
Gene namesi | Name:ABHD17CBy similarity ORF Names:RCJMB04_14o5 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Endosome
- Recycling endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Plasma membrane
- postsynaptic density membrane By similarity
Other locations
- dendritic spine By similarity
Endosome
- endosome membrane Source: GO_Central
- recycling endosome membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
- postsynaptic density membrane Source: UniProtKB-SubCell
Other locations
- dendritic spine Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Endosome, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297515 | 1 – 310 | Alpha/beta hydrolase domain-containing protein 17CAdd BLAST | 310 |
Post-translational modificationi
Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization.By similarity
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
PaxDbi | Q5ZJX1 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000006420, Expressed in spermatocyte and 13 other tissues |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1552, Eukaryota |
GeneTreei | ENSGT00940000159424 |
HOGENOMi | CLU_029375_5_4_1 |
InParanoidi | Q5ZJX1 |
OMAi | GSRLNCN |
OrthoDBi | 629316at2759 |
PhylomeDBi | Q5ZJX1 |
TreeFami | TF314365 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR022742, Hydrolase_4 |
Pfami | View protein in Pfam PF12146, Hydrolase_4, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5ZJX1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEQGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVLPPEQQ
60 70 80 90 100
QEAGAASGAA TPTGSGTCSL HLSERADWQY SQRELDAVEV FFSRTARDNR
110 120 130 140 150
LGCMFVRCAP TGRYTLLFSH GNAVDLGQMC SFYIGLGSRI NCNVFSYDYS
160 170 180 190 200
GYGVSTGKPS EKNLYADIDA AWQALRTRYG VSPENIILYG QSIGTVPTVD
210 220 230 240 250
LASRYECAAV ILHSPLMSGL RVAFPDTRKT YCFDAFPSID KISKVTSPVL
260 270 280 290 300
VIHGTEDEVI DFSHGLAMYE RCPRAVEPLW VEGAGHNDIE LYAQYLERLK
310
QFISHELPNS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ720313 mRNA Translation: CAG31972.1 |
RefSeqi | NP_001007827.1, NM_001007826.1 |
Genome annotation databases
Ensembli | ENSGALT00000010361; ENSGALP00000010347; ENSGALG00000006420 |
GeneIDi | 415479 |
KEGGi | gga:415479 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ720313 mRNA Translation: CAG31972.1 |
RefSeqi | NP_001007827.1, NM_001007826.1 |
3D structure databases
AlphaFoldDBi | Q5ZJX1 |
SMRi | Q5ZJX1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000010347 |
Protein family/group databases
MEROPSi | S09.053 |
Proteomic databases
PaxDbi | Q5ZJX1 |
Genome annotation databases
Ensembli | ENSGALT00000010361; ENSGALP00000010347; ENSGALG00000006420 |
GeneIDi | 415479 |
KEGGi | gga:415479 |
Organism-specific databases
CTDi | 58489 |
Phylogenomic databases
eggNOGi | KOG1552, Eukaryota |
GeneTreei | ENSGT00940000159424 |
HOGENOMi | CLU_029375_5_4_1 |
InParanoidi | Q5ZJX1 |
OMAi | GSRLNCN |
OrthoDBi | 629316at2759 |
PhylomeDBi | Q5ZJX1 |
TreeFami | TF314365 |
Enzyme and pathway databases
Reactomei | R-GGA-9648002, RAS processing |
Miscellaneous databases
PROi | PR:Q5ZJX1 |
Gene expression databases
Bgeei | ENSGALG00000006420, Expressed in spermatocyte and 13 other tissues |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR022742, Hydrolase_4 |
Pfami | View protein in Pfam PF12146, Hydrolase_4, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AB17C_CHICK | |
Accessioni | Q5ZJX1Primary (citable) accession number: Q5ZJX1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | November 23, 2004 | |
Last modified: | May 25, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families