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Protein

U4/U6 small nuclear ribonucleoprotein Prp3

Gene

PRPF3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6 small nuclear ribonucleoprotein Prp3
Alternative name(s):
Pre-mRNA-splicing factor 3
Gene namesi
Name:PRPF3
ORF Names:RCJMB04_20b24
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123641 – 684U4/U6 small nuclear ribonucleoprotein Prp3Add BLAST684

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5ZJ85

Interactioni

Subunit structurei

Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5ZJ85
SMRiQ5ZJ85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 87PWIPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi580 – 585Poly-Val6

Phylogenomic databases

HOGENOMiHOG000205412
HOVERGENiHBG053699
InParanoidiQ5ZJ85
KOiK12843
PhylomeDBiQ5ZJ85

Family and domain databases

InterProiView protein in InterPro
IPR010541 DUF1115
IPR013881 Pre-mRNA_splic_Prp3
IPR027104 Prp3
IPR002483 PWI_dom
IPR036483 PWI_dom_sf
PANTHERiPTHR14212 PTHR14212, 1 hit
PfamiView protein in Pfam
PF06544 DUF1115, 1 hit
PF08572 PRP3, 1 hit
PF01480 PWI, 1 hit
SMARTiView protein in SMART
SM00311 PWI, 1 hit
SUPFAMiSSF101233 SSF101233, 1 hit
PROSITEiView protein in PROSITE
PS51025 PWI, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZJ85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH
60 70 80 90 100
LKPFLDDSTL RFVDKLFEAV EEGRSSRHSK SNSDRNRKRE LKDVFGDDSE
110 120 130 140 150
VSKESSGVKK RRIPRFEEVE DEPEVIPGPP SESPGMLTKL QIKQMMEAAT
160 170 180 190 200
RQIEERKKQL SFISPPTPQP KISSSSQSER LPIGNTVQPS QAATFMNDAI
210 220 230 240 250
EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI APPKVELKDQ
260 270 280 290 300
TKPTPLILDE QGRTVDATGK EIELTHRMPT LKANIRAVKR EQFKQQLKEK
310 320 330 340 350
PSEDMESNTY FDLRVSITPA QRQKRTFKFH EKGKFEKIAQ RLRTKAQLKK
360 370 380 390 400
LQAEISQAAR KTGIHTSTKL ALITPKKELK EGEIPEIEWW DSYIIPNGLD
410 420 430 440 450
LKGGTSSKKD EYFGITNLVE HPAQLNPPVD SDTPVTLGVY LTKKEQKKLR
460 470 480 490 500
RQTRREAQKE LQEKVRLGLM PPPEPKVRIS NLMRVLGTEA VQDPTKVEAH
510 520 530 540 550
VRAQMAKRQK AHEEANAARK LTAEQRKAKK IKKLKEDVSQ GVHIAVYRVR
560 570 580 590 600
NLSNPAKKFK IEANAGQLYL TGVVVLHKDV NVVVVEGGPK AQKKFKRLML
610 620 630 640 650
HRIKWDEQTS NTKGEDDDES DEESVKKTNK CSLVWEGTAK DRSFGEMKFK
660 670 680
QCPTENMARE HFKKHGAEHY WDLALSESVL ESTD
Length:684
Mass (Da):77,386
Last modified:November 23, 2004 - v1
Checksum:i7B2E11DA8887FE63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720549 mRNA Translation: CAG32208.1
RefSeqiNP_001026561.1, NM_001031390.1
UniGeneiGga.1509

Genome annotation databases

GeneIDi426667
KEGGigga:426667

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720549 mRNA Translation: CAG32208.1
RefSeqiNP_001026561.1, NM_001031390.1
UniGeneiGga.1509

3D structure databases

ProteinModelPortaliQ5ZJ85
SMRiQ5ZJ85
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5ZJ85

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi426667
KEGGigga:426667

Organism-specific databases

CTDi9129

Phylogenomic databases

HOGENOMiHOG000205412
HOVERGENiHBG053699
InParanoidiQ5ZJ85
KOiK12843
PhylomeDBiQ5ZJ85

Miscellaneous databases

PROiPR:Q5ZJ85

Family and domain databases

InterProiView protein in InterPro
IPR010541 DUF1115
IPR013881 Pre-mRNA_splic_Prp3
IPR027104 Prp3
IPR002483 PWI_dom
IPR036483 PWI_dom_sf
PANTHERiPTHR14212 PTHR14212, 1 hit
PfamiView protein in Pfam
PF06544 DUF1115, 1 hit
PF08572 PRP3, 1 hit
PF01480 PWI, 1 hit
SMARTiView protein in SMART
SM00311 PWI, 1 hit
SUPFAMiSSF101233 SSF101233, 1 hit
PROSITEiView protein in PROSITE
PS51025 PWI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRPF3_CHICK
AccessioniPrimary (citable) accession number: Q5ZJ85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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