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Protein

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Gene

HIBCH

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity).By similarity

Catalytic activityi

3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.

Pathwayi: L-valine degradation

This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120SubstrateBy similarity1
Binding sitei145Substrate; via amide nitrogenBy similarity1
Binding sitei168SubstrateBy similarity1
Binding sitei176SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processBranched-chain amino acid catabolism

Enzyme and pathway databases

UniPathwayi
UPA00362

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC:3.1.2.4)
Alternative name(s):
3-hydroxyisobutyryl-coenzyme A hydrolase
Short name:
HIB-CoA hydrolase
Short name:
HIBYL-CoA-H
Gene namesi
Name:HIBCH
ORF Names:RCJMB04_20j11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000284932? – 3853-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ5ZJ60

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003623

Structurei

3D structure databases

ProteinModelPortaliQ5ZJ60
SMRiQ5ZJ60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1684 Eukaryota
COG1024 LUCA
HOGENOMiHOG000217005
HOVERGENiHBG054809
InParanoidiQ5ZJ60
KOiK05605
PhylomeDBiQ5ZJ60

Family and domain databases

InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR032259 HIBYL-CoA-H
PfamiView protein in Pfam
PF16113 ECH_2, 1 hit
SUPFAMiSSF52096 SSF52096, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.iShow all

Q5ZJ60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARVLMAPR RLKPFNRLQV ILQHLKTCKH TDSAADVLLQ KQGGAGIITL
60 70 80 90 100
NRPKVLNALS FKMIQQIYPQ IKAWEQDPET FLIIIKGTGE KAFCAGGDVR
110 120 130 140 150
AIADAGKAGD TMTRDYFREE YRLDNAIGTC KKPYVALIDG ITMGGGVGLS
160 170 180 190 200
VHGHFRVATE KTVFAMPETA IGLFPDVGGG YFLPRLSGKI GHLLALTGFR
210 220 230 240 250
LKGRDVLKAG IATHFVESGK LPELEKDLIA LKSPSKENIA DLLNSYHMQT
260 270 280 290 300
KIDQEKEFVL DEHMERINSI FSANSMEEIV QKLKQDGSPF ATKQLEAINK
310 320 330 340 350
MSPTSLKLTL RQLREGATMS LQDVFTMEYR LSQACMRGHD FYEGVRAVLI
360 370 380
DKDQSPRWKP AALEEVSDEF VDNCFKPLGN NDLKL
Length:385
Mass (Da):42,829
Last modified:November 23, 2004 - v1
Checksum:iC9737F7C2F3DE7DA
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1RN39A0A1L1RN39_CHICK
3-hydroxyisobutyryl-CoA hydrolase, ...
HIBCH
261Annotation score:
A0A1D5NTK1A0A1D5NTK1_CHICK
3-hydroxyisobutyryl-CoA hydrolase, ...
HIBCH
381Annotation score:
A0A1D5PGW6A0A1D5PGW6_CHICK
3-hydroxyisobutyryl-CoA hydrolase, ...
HIBCH
385Annotation score:
A0A1L1RUH6A0A1L1RUH6_CHICK
3-hydroxyisobutyryl-CoA hydrolase, ...
HIBCH
274Annotation score:
A0A1D5PFA6A0A1D5PFA6_CHICK
3-hydroxyisobutyryl-CoA hydrolase, ...
HIBCH
388Annotation score:
A0A1L1RS68A0A1L1RS68_CHICK
3-hydroxyisobutyryl-CoA hydrolase, ...
HIBCH
122Annotation score:
A0A1L1RXZ1A0A1L1RXZ1_CHICK
3-hydroxyisobutyryl-CoA hydrolase, ...
HIBCH
381Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720574 mRNA Translation: CAG32233.1
RefSeqiNP_001026414.1, NM_001031243.1
UniGeneiGga.9512

Genome annotation databases

GeneIDi423979
KEGGigga:423979

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720574 mRNA Translation: CAG32233.1
RefSeqiNP_001026414.1, NM_001031243.1
UniGeneiGga.9512

3D structure databases

ProteinModelPortaliQ5ZJ60
SMRiQ5ZJ60
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003623

Proteomic databases

PaxDbiQ5ZJ60

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi423979
KEGGigga:423979

Organism-specific databases

CTDi26275

Phylogenomic databases

eggNOGiKOG1684 Eukaryota
COG1024 LUCA
HOGENOMiHOG000217005
HOVERGENiHBG054809
InParanoidiQ5ZJ60
KOiK05605
PhylomeDBiQ5ZJ60

Enzyme and pathway databases

UniPathwayi
UPA00362

Miscellaneous databases

PROiPR:Q5ZJ60

Family and domain databases

InterProiView protein in InterPro
IPR029045 ClpP/crotonase-like_dom_sf
IPR032259 HIBYL-CoA-H
PfamiView protein in Pfam
PF16113 ECH_2, 1 hit
SUPFAMiSSF52096 SSF52096, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHIBCH_CHICK
AccessioniPrimary (citable) accession number: Q5ZJ60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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