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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 2

Gene

DYRK2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Protein has several cofactor binding sites:

Activity regulationi

Autophosphorylates on tyrosine residues.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei176ATPPROSITE-ProRule annotationBy similarity1
Active sitei273Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi153 – 161ATPPROSITE-ProRule annotationBy similarity9
Nucleotide bindingi226 – 229ATPPROSITE-ProRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Biological processApoptosis
LigandATP-binding, Magnesium, Manganese, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-6804756 Regulation of TP53 Activity through Phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC:2.7.12.1)
Gene namesi
Name:DYRK2By similarity
ORF Names:RCJMB04_23i19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002912661 – 526Dual specificity tyrosine-phosphorylation-regulated kinase 2Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31Phosphothreonine; by ATMBy similarity1
Modified residuei307PhosphotyrosineBy similarity1
Modified residuei367Phosphoserine; by ATMBy similarity1

Post-translational modificationi

Phosphorylated on serine/threonine residues. Phosphorylation on Thr-31 and Ser-367 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasome degradation, thus promoting p53/TP53-mediated apoptosis (By similarity).By similarity
Ubiquitination in nucleus by MDM2 in normal conditions leads to proteasome degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5ZIU3
PRIDEiQ5ZIU3

Expressioni

Gene expression databases

BgeeiENSGALG00000009901 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Subunit structurei

Interacts with MDM2.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016084

Structurei

3D structure databases

ProteinModelPortaliQ5ZIU3
SMRiQ5ZIU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 460Protein kinasePROSITE-ProRule annotationAdd BLAST314

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 116Nuclear localization signalBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00760000119032
HOGENOMiHOG000220863
HOVERGENiHBG051426
InParanoidiQ5ZIU3
KOiK18669
OMAiKLTTFEH
OrthoDBiEOG091G0Q46
PhylomeDBiQ5ZIU3
TreeFamiTF314624

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZIU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEHLHVGSH GQIQVQQLFE DNSNKRTVLT TQPNGLTTLG KSGLPVVQDR
60 70 80 90 100
QSESAHRRQG SSSSLKSTDG TGKVKASVMT PEQAMKQYMQ KLTTFEHNEI
110 120 130 140 150
FGYTEIYFLG PNAKKRQGVI GGPNNCGYDD DQGSYIQVPH DHIAYRYEVL
160 170 180 190 200
KVIGKGSFGQ VVKAYDHKMH QHVALKMVRN EKRFHRQAAE EIRILEHLRK
210 220 230 240 250
QDKDNNMNVI HMLENFTFRS HICMTFELLS MNLYELIKKN KFQGFSLPLV
260 270 280 290 300
RKFAHSILQC LDALHKNRII HCDLKPENIL LKQQGRSGIK VIDFGSSCYE
310 320 330 340 350
HQRVYTYIQS RFYRAPEVIL GARYGMPIDM WSLGCILAEL LTGYPLLPGE
360 370 380 390 400
DEGDQLACMI ELLGMPSPKL LDSSKRAKNF VSSKGYPRYC TITTLSDGSI
410 420 430 440 450
ILNGGRSRRG KLRGPPESRE WGNALKGCDD PLFLDFLKQC LEWDPAIRMT
460 470 480 490 500
PSQALRHPWL RRRLPKPPTG EKASAKRITE STGAITSISK LPPTSSSASK
510 520
LRTNLAQMTD ANGNIQQRTV LPKLVS
Length:526
Mass (Da):59,437
Last modified:November 23, 2004 - v1
Checksum:iE294B808874225A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720691 mRNA Translation: CAG32350.1
RefSeqiNP_001026651.1, NM_001031480.1
XP_015137471.1, XM_015281985.1
XP_015137476.1, XM_015281990.1
UniGeneiGga.13455
Gga.14403
Gga.17896

Genome annotation databases

EnsembliENSGALT00000016103; ENSGALP00000016084; ENSGALG00000009901
GeneIDi427864
KEGGigga:427864

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720691 mRNA Translation: CAG32350.1
RefSeqiNP_001026651.1, NM_001031480.1
XP_015137471.1, XM_015281985.1
XP_015137476.1, XM_015281990.1
UniGeneiGga.13455
Gga.14403
Gga.17896

3D structure databases

ProteinModelPortaliQ5ZIU3
SMRiQ5ZIU3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016084

Proteomic databases

PaxDbiQ5ZIU3
PRIDEiQ5ZIU3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016103; ENSGALP00000016084; ENSGALG00000009901
GeneIDi427864
KEGGigga:427864

Organism-specific databases

CTDi8445

Phylogenomic databases

eggNOGiKOG0667 Eukaryota
ENOG410XPET LUCA
GeneTreeiENSGT00760000119032
HOGENOMiHOG000220863
HOVERGENiHBG051426
InParanoidiQ5ZIU3
KOiK18669
OMAiKLTTFEH
OrthoDBiEOG091G0Q46
PhylomeDBiQ5ZIU3
TreeFamiTF314624

Enzyme and pathway databases

ReactomeiR-GGA-6804756 Regulation of TP53 Activity through Phosphorylation

Miscellaneous databases

PROiPR:Q5ZIU3

Gene expression databases

BgeeiENSGALG00000009901 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYRK2_CHICK
AccessioniPrimary (citable) accession number: Q5ZIU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 23, 2004
Last modified: September 12, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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