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Protein

ORM1-like protein 2

Gene

ORMDL2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negative regulator of sphingolipid synthesis.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ORM1-like protein 2
Gene namesi
Name:ORMDL2
ORF Names:RCJMB04_23j5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156381 – 153ORM1-like protein 2Add BLAST153

Proteomic databases

PaxDbiQ5ZIU0
PRIDEiQ5ZIU0

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023544

Family & Domainsi

Sequence similaritiesi

Belongs to the ORM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3319 Eukaryota
COG5081 LUCA
HOGENOMiHOG000192741
HOVERGENiHBG080033
InParanoidiQ5ZIU0
PhylomeDBiQ5ZIU0

Family and domain databases

InterProiView protein in InterPro
IPR007203 ORMDL
IPR029886 ORML2
PANTHERiPTHR12665 PTHR12665, 1 hit
PTHR12665:SF13 PTHR12665:SF13, 1 hit
PfamiView protein in Pfam
PF04061 ORMDL, 1 hit
PIRSFiPIRSF018147 ORMDL, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZIU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVGVAHSEV NPNTRVMSSR GIWLAYVISV AALHVILLSI PFFSIPVVWT
60 70 80 90 100
LTNVIHNLVM YLLLHTVKGT PFETPDQGKD RLLTHWEQID YGMQCTSSRK
110 120 130 140 150
FLSISPVVLY LLTSFYIKYD PAHFMINTAS LLSVLLPKLP QFHGVRVFGI

NKY
Length:153
Mass (Da):17,360
Last modified:November 23, 2004 - v1
Checksum:i331805C2B1406197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720694 mRNA Translation: CAG32353.1
RefSeqiNP_001026496.1, NM_001031325.1
UniGeneiGga.5902

Genome annotation databases

GeneIDi425059
KEGGigga:425059

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720694 mRNA Translation: CAG32353.1
RefSeqiNP_001026496.1, NM_001031325.1
UniGeneiGga.5902

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023544

Proteomic databases

PaxDbiQ5ZIU0
PRIDEiQ5ZIU0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi425059
KEGGigga:425059

Organism-specific databases

CTDi29095

Phylogenomic databases

eggNOGiKOG3319 Eukaryota
COG5081 LUCA
HOGENOMiHOG000192741
HOVERGENiHBG080033
InParanoidiQ5ZIU0
PhylomeDBiQ5ZIU0

Miscellaneous databases

PROiPR:Q5ZIU0

Family and domain databases

InterProiView protein in InterPro
IPR007203 ORMDL
IPR029886 ORML2
PANTHERiPTHR12665 PTHR12665, 1 hit
PTHR12665:SF13 PTHR12665:SF13, 1 hit
PfamiView protein in Pfam
PF04061 ORMDL, 1 hit
PIRSFiPIRSF018147 ORMDL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiORML2_CHICK
AccessioniPrimary (citable) accession number: Q5ZIU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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