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Protein

Coatomer subunit epsilon

Gene

COPE

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-GGA-6807878 COPI-mediated anterograde transport
R-GGA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit epsilon
Alternative name(s):
Epsilon-coat protein
Short name:
Epsilon-COP
Gene namesi
Name:COPE
ORF Names:RCJMB04_25f12
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003286661 – 308Coatomer subunit epsilonAdd BLAST308

Proteomic databases

PaxDbiQ5ZIK9
PRIDEiQ5ZIK9

Expressioni

Gene expression databases

BgeeiENSGALG00000003153 Expressed in 11 organ(s), highest expression level in colon

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.By similarity

Protein-protein interaction databases

BioGridi681127, 1 interactor
STRINGi9031.ENSGALP00000004982

Structurei

3D structure databases

ProteinModelPortaliQ5ZIK9
SMRiQ5ZIK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COPE family.Curated

Phylogenomic databases

eggNOGiKOG3081 Eukaryota
ENOG410XS5P LUCA
GeneTreeiENSGT00390000003478
HOGENOMiHOG000205825
HOVERGENiHBG002201
InParanoidiQ5ZIK9
KOiK17268
OMAiDAFHIYQ
OrthoDBiEOG091G0KHF
PhylomeDBiQ5ZIK9
TreeFamiTF313390

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR006822 Coatomer_esu
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR10805 PTHR10805, 1 hit
PIRSFiPIRSF016478 Coatomer_esu, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZIK9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGAGAGPA GQGGEADELF DVKNSFYIGA YQAAINEAQR IKPSNPEKET
60 70 80 90 100
ERDVFLFRSY IAQRKYGVVL DEIKANASPE LQAVRMFAEY LSNESQRDAI
110 120 130 140 150
VADLDKKMAK SVDVANTTFL LMAASIYFHD KNPDAALRTL HQGESLECMA
160 170 180 190 200
MMIQILLKLD RLDLARKELK KMQEQDEDAT LTQLATAWVN LAIGGEKLQD
210 220 230 240 250
AYYIFQEMAD KCSSTLLLLN GQAACYMAQG KWDDAEGVLQ EALDKDSGHP
260 270 280 290 300
ETLINFVVLS QHLGKPPEVT NRYLSQLKDA HKNHPFIKEY QAKENDFDRL

AMQYAPSA
Length:308
Mass (Da):34,369
Last modified:November 23, 2004 - v1
Checksum:iF6B4F2FB90CD2A57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720775 mRNA Translation: CAG32434.1
RefSeqiNP_001006339.1, NM_001006339.1
UniGeneiGga.6968

Genome annotation databases

EnsembliENSGALT00000004991; ENSGALP00000004982; ENSGALG00000003153
GeneIDi420117
KEGGigga:420117

Similar proteinsi

Entry informationi

Entry nameiCOPE_CHICK
AccessioniPrimary (citable) accession number: Q5ZIK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 23, 2004
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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