UniProtKB - Q5ZGX3 (Q5ZGX3_HUMAN)
Protein
5-hydroxytryptamine receptor 1A
Gene
5HT1A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled serotonin receptor activity Source: Ensembl
GO - Biological processi
- behavioral fear response Source: Ensembl
- cell population proliferation Source: InterPro
- exploration behavior Source: Ensembl
- regulation of behavior Source: InterPro
- regulation of dopamine metabolic process Source: Ensembl
- regulation of hormone secretion Source: InterPro
- regulation of serotonin secretion Source: Ensembl
- serotonin metabolic process Source: Ensembl
- vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 1AARBA annotationAlternative name(s): Serotonin receptor 1AARBA annotation |
Gene namesi | Name:5HT1AImported Synonyms:HTR1AImported ORF Names:hCG_16836Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000178394.4 |
Subcellular locationi
Other locations
- dendrite ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Other locations
- dendrite Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 41 – 63 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 70 – 99 | HelicalSequence analysisAdd BLAST | 30 | |
Transmembranei | 111 – 132 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 153 – 175 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 195 – 218 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 347 – 368 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 380 – 403 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000178394, Expressed in temporal lobe and 36 other tissues |
ExpressionAtlasi | Q5ZGX3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 400 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 348 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 235 – 262 | DisorderedSequence analysisAdd BLAST | 28 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 321 – 341 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_11_1_1 |
OMAi | DPGYTIY |
OrthoDBi | 703991at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000610, 5HT1A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF20, PTHR24247:SF20, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00512, 5HT1ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5ZGX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA
60 70 80 90 100
VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN
110 120 130 140 150
KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP
160 170 180 190 200
RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST
210 220 230 240 250
FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP
260 270 280 290 300
KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN
310 320 330 340 350
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII
360 370 380 390 400
MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY
410 420
AYFNKDFQNA FKKIIKCKFC RQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC136263 mRNA Translation: AAI36264.1 AJ781317 Genomic DNA Translation: CAH03197.1 CH471137 Genomic DNA Translation: EAW51377.1 |
RefSeqi | NP_000515.2, NM_000524.3 |
Genome annotation databases
GeneIDi | 3350 |
KEGGi | hsa:3350 |
UCSCi | uc011cqt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC136263 mRNA Translation: AAI36264.1 AJ781317 Genomic DNA Translation: CAH03197.1 CH471137 Genomic DNA Translation: EAW51377.1 |
RefSeqi | NP_000515.2, NM_000524.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
BindingDBi | Q5ZGX3 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
MaxQBi | Q5ZGX3 |
Protocols and materials databases
Antibodypediai | 2959, 309 antibodies |
DNASUi | 3350 |
Genome annotation databases
GeneIDi | 3350 |
KEGGi | hsa:3350 |
UCSCi | uc011cqt.4, human |
Organism-specific databases
CTDi | 3350 |
EuPathDBi | HostDB:ENSG00000178394.4 |
PharmGKBi | PA192 |
Phylogenomic databases
HOGENOMi | CLU_009579_11_1_1 |
OMAi | DPGYTIY |
OrthoDBi | 703991at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3350, 3 hits in 839 CRISPR screens |
GenomeRNAii | 3350 |
Gene expression databases
Bgeei | ENSG00000178394, Expressed in temporal lobe and 36 other tissues |
ExpressionAtlasi | Q5ZGX3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000610, 5HT1A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF20, PTHR24247:SF20, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00512, 5HT1ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5ZGX3_HUMAN | |
Accessioni | Q5ZGX3Primary (citable) accession number: Q5ZGX3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |