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UniProtKB - Q5Z8Q9 (PRP2A_ORYSJ)

Entry version 101 (25 May 2022)
Sequence version 2 (28 Nov 2006)
Previous versions | rss
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Protein

Poly [ADP-ribose] polymerase 2-A

Gene

PARP2-A

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Glycosyltransferase, Transferase
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 2-A (EC:2.4.2.30By similarity)
Short name:
PARP-2-A
Alternative name(s):
NAD(+) ADP-ribosyltransferase 2-A
Short name:
ADPRT-2-A
Poly[ADP-ribose] synthase 2-A
Protein ADP-ribosyltransferase PARP2By similarity (EC:2.4.2.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARP2-A
Ordered Locus Names:Os01g0351200, LOC_Os01g24940
ORF Names:B1051E10.55, P0463A02.25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryza sativa subsp. japonica (Rice)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri39947 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000059680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1
  • UP000000763 Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002605031 – 660Poly [ADP-ribose] polymerase 2-AAdd BLAST660

Keywords - PTMi

ADP-ribosylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5Z8Q9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5Z8Q9, OS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		4530.OS01T0351200-00

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q5Z8Q9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5Z8Q9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 36SAP 1PROSITE-ProRule annotationAdd BLAST35
Domaini91 – 125SAP 2PROSITE-ProRule annotationAdd BLAST35
Domaini179 – 281WGRPROSITE-ProRule annotationAdd BLAST103
Domaini308 – 426PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST119
Domaini434 – 660PARP catalyticPROSITE-ProRule annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 92DisorderedSequence analysisAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi69 – 75Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 87Basic and acidic residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARTD/PARP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1037, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004841_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5Z8Q9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.720.30, 2 hits
1.20.142.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR004102, Poly(ADP-ribose)pol_reg_dom
IPR036616, Poly(ADP-ribose)pol_reg_dom_sf
IPR003034, SAP_dom
IPR036361, SAP_dom_sf
IPR036930, WGR_dom_sf
IPR008893, WGR_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00644, PARP, 1 hit
PF02877, PARP_reg, 1 hit
PF02037, SAP, 2 hits
PF05406, WGR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00513, SAP, 2 hits
SM00773, WGR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF142921, SSF142921, 1 hit
SSF47587, SSF47587, 1 hit
SSF68906, SSF68906, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51060, PARP_ALPHA_HD, 1 hit
PS51059, PARP_CATALYTIC, 1 hit
PS50800, SAP, 2 hits
PS51977, WGR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5Z8Q9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSARLRVEEL RAELQRRGLD ASGNKPVLVR RLDAAIRKEE EEEAAVSAAA 
        60         70         80         90        100
KEEADAGGVV DGEGNGEDKR KRKRRGDGED VDNSESDAAK LEGMSYRELQ 
       110        120        130        140        150
ALAKSRGLAA NGSKKEVIER LLCAPSDTDG GVQDKKKIAK GFADGDDRVE 
       160        170        180        190        200
ECRKEKIVTA TRKGAAVLDQ HIPDHIKMTY HVLQVWFLLK GDEIYDATMN 
       210        220        230        240        250
QTNVGDNNNK FYIIQALESD AGGSFMVYNR WGRVGARGQD KLHGPFSSRE 
       260        270        280        290        300
QAIYEFEGKF HGKTNNHWSD RKSFECYARK YTWLEMDYGE ADRETNKKVS 
       310        320        330        340        350
PSTDQIKETK LETRIASFIS LICNISMMKQ QMVEIGYNSD KLPLGKLSKS 
       360        370        380        390        400
TIFKGYDVLK RISNVISRAD RRQLEQLTGE FYTVIPHDFG FKKMREFIID 
       410        420        430        440        450
TPQKLKAKLE MVEALGEIEI ATKLLEDDST DQDDPLYARY KQLSCDFTPL 
       460        470        480        490        500
EVGSEEYSMI KTYLANTHGK THTSYTVDVV QIFKVSRHGE MERFQKFATA 
       510        520        530        540        550
GNRMLLWHGS RLTNWAGILS QGLRIAPPEA PVTGYMFGKG VYFADMFSKS 
       560        570        580        590        600
ANYCYASEAC RSGVLLLCEV ALGEMNELLN ADYDANNLPK GKLSTKGVGQ 
       610        620        630        640        650
TEPNTAESKI TDDGVVVPLG KPKAEPSKRG SLLYNEFIVY NVDQIRMRYV 
       660
LHVSFNFKKR
Length:660
Mass (Da):74,297
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94FA8F38B72470A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N7KCX5A0A0N7KCX5_ORYSJ
Poly [ADP-ribose] polymerase
Os01g0351200, OSNPB_010351200
650Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD52929 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD53855 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF04898 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AP003258 Genomic DNA Translation: BAD52929.1 Sequence problems.
AP003764 Genomic DNA Translation: BAD53855.1 Sequence problems.
AP008207 Genomic DNA Translation: BAF04898.2 Sequence problems.
AP014957 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003258 Genomic DNA Translation: BAD52929.1 Sequence problems.
AP003764 Genomic DNA Translation: BAD53855.1 Sequence problems.
AP008207 Genomic DNA Translation: BAF04898.2 Sequence problems.
AP014957 Genomic DNA No translation available.

3D structure databases

AlphaFoldDBiQ5Z8Q9
SMRiQ5Z8Q9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4530.OS01T0351200-00

Proteomic databases

PaxDbiQ5Z8Q9

Phylogenomic databases

eggNOGiKOG1037, Eukaryota
HOGENOMiCLU_004841_2_1_1
InParanoidiQ5Z8Q9

Gene expression databases

GenevisibleiQ5Z8Q9, OS

Family and domain databases

Gene3Di1.10.720.30, 2 hits
1.20.142.10, 1 hit
InterProiView protein in InterPro
IPR012317, Poly(ADP-ribose)pol_cat_dom
IPR004102, Poly(ADP-ribose)pol_reg_dom
IPR036616, Poly(ADP-ribose)pol_reg_dom_sf
IPR003034, SAP_dom
IPR036361, SAP_dom_sf
IPR036930, WGR_dom_sf
IPR008893, WGR_domain
PfamiView protein in Pfam
PF00644, PARP, 1 hit
PF02877, PARP_reg, 1 hit
PF02037, SAP, 2 hits
PF05406, WGR, 1 hit
SMARTiView protein in SMART
SM00513, SAP, 2 hits
SM00773, WGR, 1 hit
SUPFAMiSSF142921, SSF142921, 1 hit
SSF47587, SSF47587, 1 hit
SSF68906, SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS51060, PARP_ALPHA_HD, 1 hit
PS51059, PARP_CATALYTIC, 1 hit
PS50800, SAP, 2 hits
PS51977, WGR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRP2A_ORYSJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5Z8Q9
Secondary accession number(s): Q0JMY0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: May 25, 2022
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families
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