UniProtKB - Q5Z8Q9 (PRP2A_ORYSJ)
Protein
Poly [ADP-ribose] polymerase 2-A
Gene
PARP2-A
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).By similarity
Catalytic activityi
- NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.By similarity EC:2.4.2.30
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- NAD+ ADP-ribosyltransferase activity Source: GO_Central
- protein ADP-ribosylase activity Source: GO_Central
GO - Biological processi
- double-strand break repair Source: GO_Central
- protein poly-ADP-ribosylation Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Glycosyltransferase, Transferase |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PARP2-A Ordered Locus Names:Os01g0351200, LOC_Os01g24940 ORF Names:B1051E10.55, P0463A02.25 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000260503 | 1 – 660 | Poly [ADP-ribose] polymerase 2-AAdd BLAST | 660 |
Keywords - PTMi
ADP-ribosylationProteomic databases
PaxDbi | Q5Z8Q9 |
PRIDEi | Q5Z8Q9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 36 | SAP 1PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 91 – 125 | SAP 2PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 308 – 426 | PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST | 119 | |
Domaini | 434 – 660 | PARP catalyticPROSITE-ProRule annotationAdd BLAST | 227 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 69 – 75 | Nuclear localization signalSequence analysis | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 39 – 43 | Poly-Glu | 5 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1037, Eukaryota |
HOGENOMi | CLU_004841_2_1_1 |
InParanoidi | Q5Z8Q9 |
Family and domain databases
Gene3Di | 1.10.720.30, 2 hits 1.20.142.10, 1 hit 2.20.140.10, 1 hit |
InterProi | View protein in InterPro IPR012317, Poly(ADP-ribose)pol_cat_dom IPR004102, Poly(ADP-ribose)pol_reg_dom IPR036616, Poly(ADP-ribose)pol_reg_dom_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR036930, WGR_dom_sf IPR008893, WGR_domain |
Pfami | View protein in Pfam PF00644, PARP, 1 hit PF02877, PARP_reg, 1 hit PF02037, SAP, 2 hits PF05406, WGR, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 2 hits SM00773, WGR, 1 hit |
SUPFAMi | SSF142921, SSF142921, 1 hit SSF47587, SSF47587, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51060, PARP_ALPHA_HD, 1 hit PS51059, PARP_CATALYTIC, 1 hit PS50800, SAP, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5Z8Q9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSARLRVEEL RAELQRRGLD ASGNKPVLVR RLDAAIRKEE EEEAAVSAAA
60 70 80 90 100
KEEADAGGVV DGEGNGEDKR KRKRRGDGED VDNSESDAAK LEGMSYRELQ
110 120 130 140 150
ALAKSRGLAA NGSKKEVIER LLCAPSDTDG GVQDKKKIAK GFADGDDRVE
160 170 180 190 200
ECRKEKIVTA TRKGAAVLDQ HIPDHIKMTY HVLQVWFLLK GDEIYDATMN
210 220 230 240 250
QTNVGDNNNK FYIIQALESD AGGSFMVYNR WGRVGARGQD KLHGPFSSRE
260 270 280 290 300
QAIYEFEGKF HGKTNNHWSD RKSFECYARK YTWLEMDYGE ADRETNKKVS
310 320 330 340 350
PSTDQIKETK LETRIASFIS LICNISMMKQ QMVEIGYNSD KLPLGKLSKS
360 370 380 390 400
TIFKGYDVLK RISNVISRAD RRQLEQLTGE FYTVIPHDFG FKKMREFIID
410 420 430 440 450
TPQKLKAKLE MVEALGEIEI ATKLLEDDST DQDDPLYARY KQLSCDFTPL
460 470 480 490 500
EVGSEEYSMI KTYLANTHGK THTSYTVDVV QIFKVSRHGE MERFQKFATA
510 520 530 540 550
GNRMLLWHGS RLTNWAGILS QGLRIAPPEA PVTGYMFGKG VYFADMFSKS
560 570 580 590 600
ANYCYASEAC RSGVLLLCEV ALGEMNELLN ADYDANNLPK GKLSTKGVGQ
610 620 630 640 650
TEPNTAESKI TDDGVVVPLG KPKAEPSKRG SLLYNEFIVY NVDQIRMRYV
660
LHVSFNFKKR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0N7KCX5 | A0A0N7KCX5_ORYSJ | Poly [ADP-ribose] polymerase | Os01g0351200, OSNPB_010351200 | 650 | Annotation score: |
Sequence cautioni
The sequence BAD52929 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD53855 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF04898 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003258 Genomic DNA Translation: BAD52929.1 Sequence problems. AP003764 Genomic DNA Translation: BAD53855.1 Sequence problems. AP008207 Genomic DNA Translation: BAF04898.2 Sequence problems. AP014957 Genomic DNA No translation available. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP003258 Genomic DNA Translation: BAD52929.1 Sequence problems. AP003764 Genomic DNA Translation: BAD53855.1 Sequence problems. AP008207 Genomic DNA Translation: BAF04898.2 Sequence problems. AP014957 Genomic DNA No translation available. |
3D structure databases
SMRi | Q5Z8Q9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS01T0351200-00 |
Proteomic databases
PaxDbi | Q5Z8Q9 |
PRIDEi | Q5Z8Q9 |
Phylogenomic databases
eggNOGi | KOG1037, Eukaryota |
HOGENOMi | CLU_004841_2_1_1 |
InParanoidi | Q5Z8Q9 |
Gene expression databases
Genevisiblei | Q5Z8Q9, OS |
Family and domain databases
Gene3Di | 1.10.720.30, 2 hits 1.20.142.10, 1 hit 2.20.140.10, 1 hit |
InterProi | View protein in InterPro IPR012317, Poly(ADP-ribose)pol_cat_dom IPR004102, Poly(ADP-ribose)pol_reg_dom IPR036616, Poly(ADP-ribose)pol_reg_dom_sf IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR036930, WGR_dom_sf IPR008893, WGR_domain |
Pfami | View protein in Pfam PF00644, PARP, 1 hit PF02877, PARP_reg, 1 hit PF02037, SAP, 2 hits PF05406, WGR, 1 hit |
SMARTi | View protein in SMART SM00513, SAP, 2 hits SM00773, WGR, 1 hit |
SUPFAMi | SSF142921, SSF142921, 1 hit SSF47587, SSF47587, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51060, PARP_ALPHA_HD, 1 hit PS51059, PARP_CATALYTIC, 1 hit PS50800, SAP, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRP2A_ORYSJ | |
Accessioni | Q5Z8Q9Primary (citable) accession number: Q5Z8Q9 Secondary accession number(s): Q0JMY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | November 28, 2006 | |
Last modified: | August 12, 2020 | |
This is version 96 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations