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Entry version 109 (16 Oct 2019)
Sequence version 1 (23 Nov 2004)
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Protein
Submitted name:

MarR family regulatory protein

Gene

mepR

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MarR family regulatory proteinImported
Submitted name:
MarR family transcriptional regulatorImported
Submitted name:
MepA/mepB repressor and autoregulatorImported
Submitted name:
MepRImported
Submitted name:
Multidrug efflux MATE transporter transcriptional repressor MepRImported
Submitted name:
Transcriptional regulatorImported
Submitted name:
Transcriptional regulator, MarR familyImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mepRImported
ORF Names:BN1321_80052Imported, BTN44_11220Imported, DB727_00690Imported, EP54_02880Imported, EQ90_08705Imported, ERS072840_01506Imported, M1K003_0421Imported, NCTC10654_00435Imported, NCTC10702_00659Imported, NCTC13131_05788Imported, NCTC5664_00388Imported, NCTC7878_00347Imported, NCTC7988_00351Imported, RK64_02240Imported, SAMEA1708674_01763Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000039437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000271693 Componenti: Chromosome 1
  • UP000251686 Componenti: Unassembled WGS sequence
  • UP000265645 Componenti: Unassembled WGS sequence
  • UP000236484 Componenti: Chromosome
  • UP000069800 Componenti: Unassembled WGS sequence
  • UP000254502 Componenti: Unassembled WGS sequence
  • UP000249913 Componenti: Unassembled WGS sequence
  • UP000249308 Componenti: Unassembled WGS sequence
  • UP000255075 Componenti: Unassembled WGS sequence
  • UP000035281 Componenti: Chromosome
  • UP000254116 Componenti: Unassembled WGS sequence
  • UP000305333 Componenti: Unassembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 136HTH marR-typeInterPro annotationAdd BLAST135

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105QNT Bacteria
ENOG41121PJ LUCA

KEGG Orthology (KO)

More...
KOi
K18909

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000835 HTH_MarR-typ
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01047 MarR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00598 HTHMARR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00347 HTH_MARR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50995 HTH_MARR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5Y812-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFTYSYLFR MISHEMKQKA DQKLEQFDIT NEQGHTLGYL YAHQQDGLTQ
60 70 80 90 100
NDIAKALQRT GPTVSNLLRN LERKKLIYRY VDAQDTRRKN IGLTTSGIKL
110 120 130
VEAFTSIFDE MEQTLVSQLS EEENEQMKAN LTKMLSSLQ
Length:139
Mass (Da):16,172
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E9BCE2D3EA4312D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY661734 Genomic DNA Translation: AAU95767.1
MF150005 Genomic DNA Translation: ATN38927.1
MF150006 Genomic DNA Translation: ATN38930.1
CP018629 Genomic DNA Translation: AUS75764.1
CP026962 Genomic DNA Translation: AVG63065.1
CVOQ01000067 Genomic DNA Translation: CRI23110.1
FGEC01000009 Genomic DNA Translation: CXN76588.1
BDVT01000002 Genomic DNA Translation: GBV19449.1
LALJ01000016 Genomic DNA Translation: KMR36356.1
LALQ01000009 Genomic DNA Translation: KMR58063.1
FMPP01000008 Genomic DNA Translation: SCS97806.1
UAUX01000003 Genomic DNA Translation: SPZ96927.1
UAUZ01000005 Genomic DNA Translation: SQA19488.1
UHAQ01000002 Genomic DNA Translation: SUK32219.1
UHBX01000004 Genomic DNA Translation: SUL23896.1
UHBY01000003 Genomic DNA Translation: SUL32201.1
QBKY01000001 Genomic DNA Translation: TKG86838.1
LR134271 Genomic DNA Translation: VED77990.1

NCBI Reference Sequences

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RefSeqi
WP_000397416.1, NZ_VHNE01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AOO97567; AOO97567; FORC27_0329
CFG05715; CFG05715; ERS093009_01867
CRI23110; CRI23110; BN1321_80052
CXE69996; CXE69996; ERS074020_01673
CXM28870; CXM28870; ERS072738_02057
CXN76588; CXN76588; ERS072840_01506
CXT08121; CXT08121; ERS073147_01251
CYD20748; CYD20748; ERS073767_01458
CZQ26963; CZQ26963; ERS1058648_00696
OAP74522; OAP74522; A4U86_06360
SCQ91768; SCQ91768; SAMEA2298760_00305

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
saud:CH52_04060
saur:SABB_01515

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1280.10341.peg.330

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY661734 Genomic DNA Translation: AAU95767.1
MF150005 Genomic DNA Translation: ATN38927.1
MF150006 Genomic DNA Translation: ATN38930.1
CP018629 Genomic DNA Translation: AUS75764.1
CP026962 Genomic DNA Translation: AVG63065.1
CVOQ01000067 Genomic DNA Translation: CRI23110.1
FGEC01000009 Genomic DNA Translation: CXN76588.1
BDVT01000002 Genomic DNA Translation: GBV19449.1
LALJ01000016 Genomic DNA Translation: KMR36356.1
LALQ01000009 Genomic DNA Translation: KMR58063.1
FMPP01000008 Genomic DNA Translation: SCS97806.1
UAUX01000003 Genomic DNA Translation: SPZ96927.1
UAUZ01000005 Genomic DNA Translation: SQA19488.1
UHAQ01000002 Genomic DNA Translation: SUK32219.1
UHBX01000004 Genomic DNA Translation: SUL23896.1
UHBY01000003 Genomic DNA Translation: SUL32201.1
QBKY01000001 Genomic DNA Translation: TKG86838.1
LR134271 Genomic DNA Translation: VED77990.1
RefSeqiWP_000397416.1, NZ_VHNE01000003.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L9JX-ray3.45A/B2-139[»]
4L9NX-ray1.60A/B1-139[»]
4L9TX-ray1.79A/B1-139[»]
4L9VX-ray2.37A1-139[»]
4LD5X-ray2.40A/B/C/D/E/F/G/H1-139[»]
4LLLX-ray3.04A/B/C/D/I/J/M/O2-139[»]
4LLNX-ray2.84A/B/C/D/I/J2-139[»]
5FB2X-ray1.80A2-139[»]
5FFZX-ray2.58A2-139[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Genome annotation databases

EnsemblBacteriaiAOO97567; AOO97567; FORC27_0329
CFG05715; CFG05715; ERS093009_01867
CRI23110; CRI23110; BN1321_80052
CXE69996; CXE69996; ERS074020_01673
CXM28870; CXM28870; ERS072738_02057
CXN76588; CXN76588; ERS072840_01506
CXT08121; CXT08121; ERS073147_01251
CYD20748; CYD20748; ERS073767_01458
CZQ26963; CZQ26963; ERS1058648_00696
OAP74522; OAP74522; A4U86_06360
SCQ91768; SCQ91768; SAMEA2298760_00305
KEGGisaud:CH52_04060
saur:SABB_01515
PATRICifig|1280.10341.peg.330

Phylogenomic databases

eggNOGiENOG4105QNT Bacteria
ENOG41121PJ LUCA
KOiK18909

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000835 HTH_MarR-typ
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01047 MarR, 1 hit
PRINTSiPR00598 HTHMARR
SMARTiView protein in SMART
SM00347 HTH_MARR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50995 HTH_MARR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5Y812_STAAU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5Y812
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: October 16, 2019
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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