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UniProtKB - Q5Y7D1 (Q5Y7D1_HUMAN)
Protein
Submitted name:
HLA class II histocompatibility antigen DR beta chain
Gene
HLA-DRB1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Submitted name: HLA class II histocompatibility antigen DR beta chainImportedSubmitted name: HLA class II histocompatibility antigen, DRB1 beta chainSubmitted name: HLA-DRB1 proteinImportedSubmitted name: MHC class II antigenImportedSubmitted name: Major histocompatibility complex, class II, DR beta 1 (Clone P2-beta-3)Imported |
Gene namesi | Name:HLA-DRB1Imported ORF Names:RP1-93N13.1-001Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4948, HLA-DRB1 |
Subcellular locationi
Endosome
- Endosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Lysosome
- Lysosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 228 – 250 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
EndosomeARBA annotation, LysosomeARBA annotation, Membrane, MHC IIARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_5014310211 | 30 – 266 | Sequence analysisAdd BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 108 | Combined sources | ||
Disulfide bondi | 146 ↔ 202 | Combined sources |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationStructurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 214 | Ig-likeInterPro annotationAdd BLAST | 89 |
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OrthoDBi | 1249505at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q5Y7D1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT
60 70 80 90 100
ERVRYLDRYF HNQEENVRFD SDVGEFRAVT ELGRPDAEYW NSQKDLLEQK
110 120 130 140 150
RGRVDNYCRH NYGVVESFTV QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PRGFLS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP01911 | DRB1_HUMAN | HLA class II histocompatibility ant... | HLA-DRB1 | 266 | Annotation score: | ||
D7RIG5 | D7RIG5_HUMAN | HLA class II histocompatibility ant... | HLA-DRB1 | 266 | Annotation score: | ||
A2BFX2 | A2BFX2_HUMAN | HLA class II histocompatibility ant... | HLA-DRB1 | 266 | Annotation score: | ||
A0A140T958 | A0A140T958_HUMAN | HLA class II histocompatibility ant... | HLA-DRB1 | 250 | Annotation score: | ||
A0A5S8K7D1 | A0A5S8K7D1_HUMAN | HLA class II histocompatibility ant... | HLA-DRB1 | 250 | Annotation score: | ||
A0A5S8K798 | A0A5S8K798_HUMAN | HLA class II histocompatibility ant... | HLA-DRB1 | 251 | Annotation score: | ||
A0A5S8K7D6 | A0A5S8K7D6_HUMAN | HLA class II histocompatibility ant... | HLA-DRB1 | 251 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL662842 Genomic DNA No translation available. AL929581 Genomic DNA No translation available. AY663399 Genomic DNA Translation: AAU87990.1 AY663407 Genomic DNA Translation: AAU88011.1 AY961064 mRNA Translation: AAX63452.1 HM067844 mRNA Translation: ADI59556.1 AB829524 Genomic DNA Translation: BAO73159.1 LC257774 Genomic DNA Translation: BBD34092.1 Z84489 Genomic DNA Translation: CAB06490.1 LR878369 Genomic DNA Translation: CAD5127856.1 LR878371 Genomic DNA Translation: CAD5127858.1 LR878373 Genomic DNA Translation: CAD5127860.1 LR878374 Genomic DNA Translation: CAD5127861.1 LR878398 Genomic DNA Translation: CAD5127885.1 LR878422 Genomic DNA Translation: CAD5127909.1 LR878423 Genomic DNA Translation: CAD5127910.1 LR880420 Genomic DNA Translation: CAD5137397.1 LR880421 Genomic DNA Translation: CAD5137398.1 LR880441 Genomic DNA Translation: CAD5137418.1 LR882675 Genomic DNA Translation: CAD5895161.1 LR882676 Genomic DNA Translation: CAD5895163.1 LR882677 Genomic DNA Translation: CAD5895164.1 LR882678 Genomic DNA Translation: CAD5895166.1 LR882737 Genomic DNA Translation: CAD5895209.1 HG993069 Genomic DNA Translation: CAE6990065.1 HG993070 Genomic DNA Translation: CAE6990068.1 OU385940 Genomic DNA Translation: CAG7912257.1 LT220256 Genomic DNA Translation: CZQ50742.1 |
RefSeqi | NP_001230894.1, NM_001243965.1 |
Genome annotation databases
Ensembli | ENST00000328980.11; ENSP00000331343.7; ENSG00000206306.10 ENST00000399450.6; ENSP00000382378.2; ENSG00000206240.11 |
GeneIDi | 3123 |
KEGGi | hsa:3123 |
UCSCi | uc063uqs.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL662842 Genomic DNA No translation available. AL929581 Genomic DNA No translation available. AY663399 Genomic DNA Translation: AAU87990.1 AY663407 Genomic DNA Translation: AAU88011.1 AY961064 mRNA Translation: AAX63452.1 HM067844 mRNA Translation: ADI59556.1 AB829524 Genomic DNA Translation: BAO73159.1 LC257774 Genomic DNA Translation: BBD34092.1 Z84489 Genomic DNA Translation: CAB06490.1 LR878369 Genomic DNA Translation: CAD5127856.1 LR878371 Genomic DNA Translation: CAD5127858.1 LR878373 Genomic DNA Translation: CAD5127860.1 LR878374 Genomic DNA Translation: CAD5127861.1 LR878398 Genomic DNA Translation: CAD5127885.1 LR878422 Genomic DNA Translation: CAD5127909.1 LR878423 Genomic DNA Translation: CAD5127910.1 LR880420 Genomic DNA Translation: CAD5137397.1 LR880421 Genomic DNA Translation: CAD5137398.1 LR880441 Genomic DNA Translation: CAD5137418.1 LR882675 Genomic DNA Translation: CAD5895161.1 LR882676 Genomic DNA Translation: CAD5895163.1 LR882677 Genomic DNA Translation: CAD5895164.1 LR882678 Genomic DNA Translation: CAD5895166.1 LR882737 Genomic DNA Translation: CAD5895209.1 HG993069 Genomic DNA Translation: CAE6990065.1 HG993070 Genomic DNA Translation: CAE6990068.1 OU385940 Genomic DNA Translation: CAG7912257.1 LT220256 Genomic DNA Translation: CZQ50742.1 |
RefSeqi | NP_001230894.1, NM_001243965.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7N19 | X-ray | 2.38 | B/E/H/K | 33-219 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protocols and materials databases
DNASUi | 3123 |
Genome annotation databases
Ensembli | ENST00000328980.11; ENSP00000331343.7; ENSG00000206306.10 ENST00000399450.6; ENSP00000382378.2; ENSG00000206240.11 |
GeneIDi | 3123 |
KEGGi | hsa:3123 |
UCSCi | uc063uqs.1, human |
Organism-specific databases
CTDi | 3123 |
HGNCi | HGNC:4948, HLA-DRB1 |
GenAtlasi | Search... |
Phylogenomic databases
OrthoDBi | 1249505at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3123, 23 hits in 993 CRISPR screens |
ChiTaRSi | HLA-DRB1, human |
GenomeRNAii | 3123 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5Y7D1_HUMAN | |
Accessioni | Q5Y7D1Primary (citable) accession number: Q5Y7D1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |