UniProtKB - Q5Y4N8 (AGRE1_RAT)
Protein
Adhesion G protein-coupled receptor E2
Gene
Adgre1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development.By similarity
Miscellaneous
Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity
GO - Molecular functioni
- calcium ion binding Source: InterPro
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Adaptive immunity, Immunity |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-RNO-373080, Class B/2 (Secretin family receptors) |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G protein-coupled receptor E2Alternative name(s): EGF-like module receptor 1 EGF-like module-containing mucin-like hormone receptor-like 1 EMR1 hormone receptor |
Gene namesi | Name:Adgre1 Synonyms:Emr1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359214, Adgre1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- external side of plasma membrane Source: RGD
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: RGD
Other locations
- cell periphery Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 16 – 652 | ExtracellularCuratedAdd BLAST | 637 | |
Transmembranei | 653 – 673 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 674 – 681 | CytoplasmicCurated | 8 | |
Transmembranei | 682 – 702 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 703 – 719 | ExtracellularCuratedAdd BLAST | 17 | |
Transmembranei | 720 – 740 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 741 – 756 | CytoplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 757 – 777 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 778 – 795 | ExtracellularCuratedAdd BLAST | 18 | |
Transmembranei | 796 – 816 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 817 – 849 | CytoplasmicCuratedAdd BLAST | 33 | |
Transmembranei | 850 – 870 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 871 – 872 | ExtracellularCurated | 2 | |
Transmembranei | 873 – 893 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 894 – 932 | CytoplasmicCuratedAdd BLAST | 39 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_0000250959 | 16 – 932 | Adhesion G protein-coupled receptor E2Add BLAST | 917 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 48 | PROSITE-ProRule annotation | ||
Disulfide bondi | 42 ↔ 57 | PROSITE-ProRule annotation | ||
Disulfide bondi | 85 ↔ 98 | PROSITE-ProRule annotation | ||
Disulfide bondi | 92 ↔ 107 | PROSITE-ProRule annotation | ||
Disulfide bondi | 137 ↔ 149 | PROSITE-ProRule annotation | ||
Disulfide bondi | 143 ↔ 158 | PROSITE-ProRule annotation | ||
Glycosylationi | 148 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 160 ↔ 171 | PROSITE-ProRule annotation | ||
Glycosylationi | 167 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 177 ↔ 189 | PROSITE-ProRule annotation | ||
Disulfide bondi | 183 ↔ 198 | PROSITE-ProRule annotation | ||
Disulfide bondi | 226 ↔ 239 | PROSITE-ProRule annotation | ||
Glycosylationi | 229 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 233 ↔ 248 | PROSITE-ProRule annotation | ||
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 276 ↔ 286 | PROSITE-ProRule annotation | ||
Disulfide bondi | 280 ↔ 295 | PROSITE-ProRule annotation | ||
Glycosylationi | 283 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 309 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 323 ↔ 336 | PROSITE-ProRule annotation | ||
Disulfide bondi | 330 ↔ 345 | PROSITE-ProRule annotation | ||
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 344 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 363 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 405 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 417 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 474 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 499 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 707 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q5Y4N8 |
PRIDEi | Q5Y4N8 |
PTM databases
GlyGeni | Q5Y4N8, 14 sites |
iPTMneti | Q5Y4N8 |
PhosphoSitePlusi | Q5Y4N8 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000046254, Expressed in spleen and 21 other tissues |
Genevisiblei | Q5Y4N8, RN |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 69 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 81 – 119 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 133 – 172 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 173 – 210 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 222 – 260 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 272 – 307 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 319 – 354 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 593 – 642 | GPSPROSITE-ProRule annotationAdd BLAST | 50 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 507 – 509 | Cell attachment siteSequence analysis | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 768 – 771 | Poly-Val | 4 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000161354 |
HOGENOMi | CLU_002753_3_7_1 |
InParanoidi | Q5Y4N8 |
OMAi | LGRYKCS |
OrthoDBi | 124090at2759 |
PhylomeDBi | Q5Y4N8 |
Family and domain databases
InterProi | View protein in InterPro IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR017981, GPCR_2-like IPR001740, GPCR_2_EMR1-like_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF12662, cEGF, 2 hits PF07645, EGF_CA, 3 hits PF01825, GPS, 1 hit |
PRINTSi | PR01128, EMR1HORMONER PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00181, EGF, 7 hits SM00179, EGF_CA, 7 hits SM00303, GPS, 1 hit |
SUPFAMi | SSF57184, SSF57184, 3 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 6 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 7 hits PS01187, EGF_CA, 5 hits PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5Y4N8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWGFWLLLFW GFSGTHRWGM TTLAILGQRL NGVNECQDTT TCPAYATCTD
60 70 80 90 100
TTESYYCTCK QGFLPSNGQT NFQGPGVECQ DVNECLRSDS PCGSNSVCTN
110 120 130 140 150
IPGRARCSCL SGFSSSAGGS WILGSPGHFL CTDVDECLTI GICPKNSNCS
160 170 180 190 200
NSVGSYSCTC QSGFVSNGST CEDEDECVTR NACPEHATCH NTLGSYYCTC
210 220 230 240 250
NEGLEFSGGG PMFQGLEESC EDVDECSRNS TLCGPSFICI NTLGSYSCSC
260 270 280 290 300
PAGFSLSTFQ IPGHPADGNC TDIDECDDIC PSNSSCTNTL GSYFCTCHPG
310 320 330 340 350
FASSNGQLNF TDQEVTCEDI DECTQDPFRC GRNSSCTNVP GSYNCSCLPD
360 370 380 390 400
FRMDPGGSQA HGNFTCKRIP FKCKEDLIPK SEQIEQCQAG QGRNLDYTSF
410 420 430 440 450
CTFVNATFTI LDNTCENKSA PVSLQSAATS VSLMLEQAST WFEFSREETS
460 470 480 490 500
TLGTILLETV ESTMLAALLT PSGNASQTIR TEYLEIESKV INEECNEENV
510 520 530 540 550
SINLKARGDK MDVGCFIIKE SESTGTPGVA FVSFAHMDSV LDERFFEDGQ
560 570 580 590 600
ASWKLRMNSH VVGGTVTGER KEDFSKPIVY TLQHIQPKQK SERSICVSWN
610 620 630 640 650
TDVEDGRWTP SGCETVEASE THTVCSCNRM TNLAIIMASG ELTMEFSLYI
660 670 680 690 700
ISYVGTVISL VCLALAIATF LLFRAVQNHN TYLHLHLCVC LFLAKILFLT
710 720 730 740 750
GIDKTDNQTA CAIIAGFLHY LFLACFFWML VEAVMLFLMV RNLKVVNYFS
760 770 780 790 800
SRNIKMLHLC AFGYGLPVVV VIISATVHPW GYGMHNRCWL NTETGFIWSF
810 820 830 840 850
LGPVCMIITI NSALLAWTLW VLRQKLCSVN SEVSKLKDTR LLTFKAIAQI
860 870 880 890 900
FILGCSWVLG IFQIGPLASI MAYLFTTINS LQGAFIFLIH CLLNRQVRDE
910 920 930
YRKLLTRKTD LSSHSQTSGI LLSSMPSTSK TG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY686632 mRNA Translation: AAU95564.1 |
RefSeqi | NP_001007558.1, NM_001007557.1 |
Genome annotation databases
Ensembli | ENSRNOT00000073926; ENSRNOP00000067220; ENSRNOG00000046254 |
GeneIDi | 316137 |
KEGGi | rno:316137 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY686632 mRNA Translation: AAU95564.1 |
RefSeqi | NP_001007558.1, NM_001007557.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000067220 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q5Y4N8, 14 sites |
iPTMneti | Q5Y4N8 |
PhosphoSitePlusi | Q5Y4N8 |
Proteomic databases
PaxDbi | Q5Y4N8 |
PRIDEi | Q5Y4N8 |
Genome annotation databases
Ensembli | ENSRNOT00000073926; ENSRNOP00000067220; ENSRNOG00000046254 |
GeneIDi | 316137 |
KEGGi | rno:316137 |
Organism-specific databases
CTDi | 2015 |
RGDi | 1359214, Adgre1 |
Phylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000161354 |
HOGENOMi | CLU_002753_3_7_1 |
InParanoidi | Q5Y4N8 |
OMAi | LGRYKCS |
OrthoDBi | 124090at2759 |
PhylomeDBi | Q5Y4N8 |
Enzyme and pathway databases
Reactomei | R-RNO-373080, Class B/2 (Secretin family receptors) |
Miscellaneous databases
PROi | PR:Q5Y4N8 |
Gene expression databases
Bgeei | ENSRNOG00000046254, Expressed in spleen and 21 other tissues |
Genevisiblei | Q5Y4N8, RN |
Family and domain databases
InterProi | View protein in InterPro IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR017981, GPCR_2-like IPR001740, GPCR_2_EMR1-like_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF12662, cEGF, 2 hits PF07645, EGF_CA, 3 hits PF01825, GPS, 1 hit |
PRINTSi | PR01128, EMR1HORMONER PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00181, EGF, 7 hits SM00179, EGF_CA, 7 hits SM00303, GPS, 1 hit |
SUPFAMi | SSF57184, SSF57184, 3 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 6 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 7 hits PS01187, EGF_CA, 5 hits PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRE1_RAT | |
Accessioni | Q5Y4N8Primary (citable) accession number: Q5Y4N8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | November 23, 2004 | |
Last modified: | April 7, 2021 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families