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Entry version 104 (07 Apr 2021)
Sequence version 1 (23 Nov 2004)
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Protein

Adhesion G protein-coupled receptor E2

Gene

Adgre1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development.By similarity

Miscellaneous

Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processAdaptive immunity, Immunity
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-373080, Class B/2 (Secretin family receptors)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor E2
Alternative name(s):
EGF-like module receptor 1
EGF-like module-containing mucin-like hormone receptor-like 1
EMR1 hormone receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adgre1
Synonyms:Emr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Rat genome database

More...
RGDi
1359214, Adgre1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini16 – 652ExtracellularCuratedAdd BLAST637
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei653 – 673Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini674 – 681CytoplasmicCurated8
Transmembranei682 – 702Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini703 – 719ExtracellularCuratedAdd BLAST17
Transmembranei720 – 740Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini741 – 756CytoplasmicCuratedAdd BLAST16
Transmembranei757 – 777Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini778 – 795ExtracellularCuratedAdd BLAST18
Transmembranei796 – 816Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini817 – 849CytoplasmicCuratedAdd BLAST33
Transmembranei850 – 870Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini871 – 872ExtracellularCurated2
Transmembranei873 – 893Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini894 – 932CytoplasmicCuratedAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025095916 – 932Adhesion G protein-coupled receptor E2Add BLAST917

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 48PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi85 ↔ 98PROSITE-ProRule annotation
Disulfide bondi92 ↔ 107PROSITE-ProRule annotation
Disulfide bondi137 ↔ 149PROSITE-ProRule annotation
Disulfide bondi143 ↔ 158PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 171PROSITE-ProRule annotation
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi177 ↔ 189PROSITE-ProRule annotation
Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi233 ↔ 248PROSITE-ProRule annotation
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi276 ↔ 286PROSITE-ProRule annotation
Disulfide bondi280 ↔ 295PROSITE-ProRule annotation
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi323 ↔ 336PROSITE-ProRule annotation
Disulfide bondi330 ↔ 345PROSITE-ProRule annotation
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi707N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5Y4N8

PRoteomics IDEntifications database

More...
PRIDEi
Q5Y4N8

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q5Y4N8, 14 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5Y4N8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5Y4N8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000046254, Expressed in spleen and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5Y4N8, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000067220

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 69EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini81 – 119EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini133 – 172EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini173 – 210EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini222 – 260EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini272 – 307EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini319 – 354EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini593 – 642GPSPROSITE-ProRule annotationAdd BLAST50

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi507 – 509Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi768 – 771Poly-Val4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002753_3_7_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5Y4N8

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGRYKCS

Database of Orthologous Groups

More...
OrthoDBi
124090at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5Y4N8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR017981, GPCR_2-like
IPR001740, GPCR_2_EMR1-like_rcpt
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR009030, Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF12662, cEGF, 2 hits
PF07645, EGF_CA, 3 hits
PF01825, GPS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01128, EMR1HORMONER
PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 7 hits
SM00179, EGF_CA, 7 hits
SM00303, GPS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 5 hits
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q5Y4N8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWGFWLLLFW GFSGTHRWGM TTLAILGQRL NGVNECQDTT TCPAYATCTD
60 70 80 90 100
TTESYYCTCK QGFLPSNGQT NFQGPGVECQ DVNECLRSDS PCGSNSVCTN
110 120 130 140 150
IPGRARCSCL SGFSSSAGGS WILGSPGHFL CTDVDECLTI GICPKNSNCS
160 170 180 190 200
NSVGSYSCTC QSGFVSNGST CEDEDECVTR NACPEHATCH NTLGSYYCTC
210 220 230 240 250
NEGLEFSGGG PMFQGLEESC EDVDECSRNS TLCGPSFICI NTLGSYSCSC
260 270 280 290 300
PAGFSLSTFQ IPGHPADGNC TDIDECDDIC PSNSSCTNTL GSYFCTCHPG
310 320 330 340 350
FASSNGQLNF TDQEVTCEDI DECTQDPFRC GRNSSCTNVP GSYNCSCLPD
360 370 380 390 400
FRMDPGGSQA HGNFTCKRIP FKCKEDLIPK SEQIEQCQAG QGRNLDYTSF
410 420 430 440 450
CTFVNATFTI LDNTCENKSA PVSLQSAATS VSLMLEQAST WFEFSREETS
460 470 480 490 500
TLGTILLETV ESTMLAALLT PSGNASQTIR TEYLEIESKV INEECNEENV
510 520 530 540 550
SINLKARGDK MDVGCFIIKE SESTGTPGVA FVSFAHMDSV LDERFFEDGQ
560 570 580 590 600
ASWKLRMNSH VVGGTVTGER KEDFSKPIVY TLQHIQPKQK SERSICVSWN
610 620 630 640 650
TDVEDGRWTP SGCETVEASE THTVCSCNRM TNLAIIMASG ELTMEFSLYI
660 670 680 690 700
ISYVGTVISL VCLALAIATF LLFRAVQNHN TYLHLHLCVC LFLAKILFLT
710 720 730 740 750
GIDKTDNQTA CAIIAGFLHY LFLACFFWML VEAVMLFLMV RNLKVVNYFS
760 770 780 790 800
SRNIKMLHLC AFGYGLPVVV VIISATVHPW GYGMHNRCWL NTETGFIWSF
810 820 830 840 850
LGPVCMIITI NSALLAWTLW VLRQKLCSVN SEVSKLKDTR LLTFKAIAQI
860 870 880 890 900
FILGCSWVLG IFQIGPLASI MAYLFTTINS LQGAFIFLIH CLLNRQVRDE
910 920 930
YRKLLTRKTD LSSHSQTSGI LLSSMPSTSK TG
Length:932
Mass (Da):102,308
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99C4B11C721EF8DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY686632 mRNA Translation: AAU95564.1

NCBI Reference Sequences

More...
RefSeqi
NP_001007558.1, NM_001007557.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000073926; ENSRNOP00000067220; ENSRNOG00000046254

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
316137

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:316137

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY686632 mRNA Translation: AAU95564.1
RefSeqiNP_001007558.1, NM_001007557.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067220

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyGeniQ5Y4N8, 14 sites
iPTMnetiQ5Y4N8
PhosphoSitePlusiQ5Y4N8

Proteomic databases

PaxDbiQ5Y4N8
PRIDEiQ5Y4N8

Genome annotation databases

EnsembliENSRNOT00000073926; ENSRNOP00000067220; ENSRNOG00000046254
GeneIDi316137
KEGGirno:316137

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2015
RGDi1359214, Adgre1

Phylogenomic databases

eggNOGiKOG4193, Eukaryota
GeneTreeiENSGT00940000161354
HOGENOMiCLU_002753_3_7_1
InParanoidiQ5Y4N8
OMAiLGRYKCS
OrthoDBi124090at2759
PhylomeDBiQ5Y4N8

Enzyme and pathway databases

ReactomeiR-RNO-373080, Class B/2 (Secretin family receptors)

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5Y4N8

Gene expression databases

BgeeiENSRNOG00000046254, Expressed in spleen and 21 other tissues
GenevisibleiQ5Y4N8, RN

Family and domain databases

InterProiView protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR017981, GPCR_2-like
IPR001740, GPCR_2_EMR1-like_rcpt
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR009030, Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF12662, cEGF, 2 hits
PF07645, EGF_CA, 3 hits
PF01825, GPS, 1 hit
PRINTSiPR01128, EMR1HORMONER
PR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00181, EGF, 7 hits
SM00179, EGF_CA, 7 hits
SM00303, GPS, 1 hit
SUPFAMiSSF57184, SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 5 hits
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRE1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5Y4N8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: April 7, 2021
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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