C-C motif chemokine

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• CCR1 chemokine receptor binding Source: Ensembl
• CCR4 chemokine receptor binding Source: InterPro
• CCR5 chemokine receptor binding Source: Ensembl
• chemoattractant activity Source: Ensembl
• chemokine activity Source: Ensembl
• chemokine receptor antagonist activity Source: Ensembl
• phosphatidylinositol phospholipase C activity Source: Ensembl
• phospholipase activator activity Source: Ensembl
• protein homodimerization activity Source: Ensembl
• protein kinase activity Source: Ensembl
• protein self-association Source: Ensembl
• receptor signaling protein tyrosine kinase activator activity Source: Ensembl

GO - Biological processⁱ

• activation of phospholipase D activity Source: Ensembl
• calcium ion transport Source: Ensembl
• cell-cell signaling Source: Ensembl
• cellular calcium ion homeostasis Source: Ensembl
• cellular response to fibroblast growth factor stimulus Source: Ensembl
• cellular response to interferon-gamma Source: Ensembl
• cellular response to interleukin-1 Source: Ensembl
• cellular response to organic cyclic compound Source: Ensembl
• cellular response to tumor necrosis factor Source: Ensembl
• chemokine-mediated signaling pathway Source: Ensembl
• eosinophil chemotaxis Source: Ensembl
• exocytosis Source: Ensembl
• G protein-coupled receptor signaling pathway Source: Ensembl
• inflammatory response Source: Ensembl
• leukocyte cell-cell adhesion Source: Ensembl
• lipopolysaccharide-mediated signaling pathway Source: Ensembl
• MAPK cascade Source: Ensembl
• negative regulation by host of viral transcription Source: Ensembl
• negative regulation of G protein-coupled receptor signaling pathway Source: Ensembl
• negative regulation of T cell apoptotic process Source: Ensembl
• negative regulation of viral genome replication Source: Ensembl
• neutrophil activation Source: Ensembl
• positive regulation of calcium ion transport Source: Ensembl
• positive regulation of cell-cell adhesion mediated by integrin Source: Ensembl
• positive regulation of cellular biosynthetic process Source: Ensembl
• positive regulation of homotypic cell-cell adhesion Source: Ensembl
• positive regulation of macrophage chemotaxis Source: Ensembl
• positive regulation of monocyte chemotaxis Source: Ensembl
• positive regulation of natural killer cell chemotaxis Source: Ensembl
• positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• positive regulation of smooth muscle cell migration Source: Ensembl
• positive regulation of smooth muscle cell proliferation Source: Ensembl
• positive regulation of T cell apoptotic process Source: Ensembl
• positive regulation of T cell chemotaxis Source: Ensembl
• positive regulation of T cell proliferation Source: Ensembl
• positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
• protein kinase B signaling Source: Ensembl
• protein tetramerization Source: Ensembl
• regulation of insulin secretion Source: Ensembl
• regulation of neuron death Source: Ensembl
• response to toxic substance Source: Ensembl
• response to virus Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• CCR1 chemokine receptor binding Source: Ensembl
• CCR4 chemokine receptor binding Source: InterPro
• CCR5 chemokine receptor binding Source: Ensembl
• chemoattractant activity Source: Ensembl
• chemokine activity Source: Ensembl
• chemokine receptor antagonist activity Source: Ensembl
• protein homodimerization activity Source: Ensembl
• protein self-association Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKISAAALTI ILTAAALCTP APASPYGSDT TPCCFAYLSL ALPRAHVKEY 
        60         70         80         90 
FYTSSKCSNL AVVFVTRRNR QVCANPEKKW VQEYINYLEM S          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ