UniProtKB - Q5XXA6 (ANO1_HUMAN)

BLAST

>sp|Q5XXA6|ANO1_HUMAN Anoctamin-1 OS=Homo sapiens OX=9606 GN=ANO1 PE=1 SV=1
MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRR
KVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYH
EDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK
MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSF
FDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKL
LYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM
DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWA
ATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHI
PEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIY
RISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEK
SFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMEL
CIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLE
PFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRA
KDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNV
SDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNL
VMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPC
NHHNTKACPDSLGSPAPSHAYHGGVL

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History
Entry version 122 (07 Nov 2018)
Sequence version 1 (23 Nov 2004)
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Protein

Anoctamin-1

Gene

ANO1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.4 Publications

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Activity regulationⁱ

ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).1 Publication

GO - Molecular functionⁱ

calcium activated cation channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22946059
chloride channel activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24885604
intracellular calcium activated chloride channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21984732
iodide transmembrane transporter activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25201006
protein dimerization activity Source: InterPro
voltage-gated chloride channel activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cation transport
Source: UniProtKB
Inferred from direct assayⁱ
- 22946059
cellular response to heat Source: UniProtKB
chloride transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24885604
chloride transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22946059
detection of temperature stimulus involved in sensory perception of pain Source: UniProtKB
iodide transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25201006
ion transmembrane transport Source: Reactome
multicellular organism development Source: UniProtKB-KW
phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
positive regulation of insulin secretion involved in cellular response to glucose stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24885604

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chloride channel, Developmental protein, Ion channel
Biological process	Ion transport, Transport
Ligand	Calcium, Chloride

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2672351 Stimuli-sensing channels

Reactomeⁱ

R-HSA-2672351 Stimuli-sensing channels

Protein family/group databases

TCDBⁱ	1.A.17.1.1 the calcium-dependent chloride channel (ca-clc) family

TCDBⁱ

1.A.17.1.1 the calcium-dependent chloride channel (ca-clc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Anoctamin-1 Alternative name(s): Discovered on gastrointestinal stromal tumors protein 1 Oral cancer overexpressed protein 2 Transmembrane protein 16A Tumor-amplified and overexpressed sequence 2
Gene namesⁱ	Name:ANO1 Synonyms:DOG1, ORAOV2, TAOS2, TMEM16A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131620.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21625 ANO1
MIMⁱ	610108 gene
neXtProtⁱ	NX_Q5XXA6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 333	CytoplasmicSequence analysisAdd BLAST	333
Transmembraneⁱ	334 – 354	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	355 – 402	ExtracellularSequence analysisAdd BLAST	48
Transmembraneⁱ	403 – 423	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	424 – 519	CytoplasmicSequence analysisAdd BLAST	96
Transmembraneⁱ	520 – 540	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	541 – 565	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	566 – 586	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	587 – 606	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	607 – 627	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	628 – 731	ExtracellularSequence analysisAdd BLAST	104
Transmembraneⁱ	732 – 752	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	753 – 791	CytoplasmicSequence analysisAdd BLAST	39
Transmembraneⁱ	792 – 812	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	813 – 882	ExtracellularSequence analysisAdd BLAST	70
Transmembraneⁱ	883 – 903	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	904 – 986	CytoplasmicSequence analysisAdd BLAST	83

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55107
Open Targets More...OpenTargetsⁱ	ENSG00000131620
PharmGKBⁱ	PA164715378

Chemistry databases

ChEMBLⁱ	CHEMBL2046267
Drug and drug target database More...DrugBankⁱ	DB04941 Crofelemer
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	708

Polymorphism and mutation databases

BioMutaⁱ	ANO1
DMDMⁱ	74708278

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000288435	1 – 986	Anoctamin-1Add BLAST		986

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	107	PhosphoserineCombined sources	1
Modified residueⁱ	196	PhosphoserineCombined sources	1
Glycosylationⁱ	832	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q5XXA6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5XXA6
PaxDbⁱ	Q5XXA6
PeptideAtlas More...PeptideAtlasⁱ	Q5XXA6
PRIDEⁱ	Q5XXA6
ProteomicsDBⁱ	65854 65855 [Q5XXA6-2] 65856 [Q5XXA6-3]

PTM databases

iPTMnetⁱ	Q5XXA6
PhosphoSitePlusⁱ	Q5XXA6

Expressionⁱ

Tissue specificityⁱ

Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000131620 Expressed in 164 organ(s), highest expression level in thoracic aorta
CleanExⁱ	HS_ANO1
ExpressionAtlasⁱ	Q5XXA6 baseline and differential
Genevisibleⁱ	Q5XXA6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA032148 HPA057356

HPAⁱ

HPA032148
HPA057356

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:21056985). Interacts with CFTR (PubMed:22178883). Interacts with TRPV4 (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120417, 1 interactor
IntActⁱ	Q5XXA6, 1 interactor
STRINGⁱ	9606.ENSP00000347454

Chemistry databases

BindingDBⁱ

Q5XXA6

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5XXA6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.By similarity

Sequence similaritiesⁱ

Belongs to the anoctamin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2514 Eukaryota ENOG410XS4S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119015
HOGENOMⁱ	HOG000006509
HOVERGENⁱ	HBG069519
InParanoidⁱ	Q5XXA6
KEGG Orthology (KO) More...KOⁱ	K19496
OMAⁱ	LYMYSEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01JF
PhylomeDBⁱ	Q5XXA6
TreeFamⁱ	TF314265

Family and domain databases

InterProⁱ	View protein in InterPro IPR032394 Anoct_dimer IPR007632 Anoctamin IPR031287 Anoctamin-1
PANTHERⁱ	PTHR12308 PTHR12308, 1 hit PTHR12308:SF13 PTHR12308:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16178 Anoct_dimer, 1 hit PF04547 Anoctamin, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5XXA6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVNEKYSTL PAEDRSVHII NICAIEDIGY LPSEGTLLNS LSVDPDAECK 
        60         70         80         90        100
YGLYFRDGRR KVDYILVYHH KRPSGNRTLV RRVQHSDTPS GARSVKQDHP 
       110        120        130        140        150
LPGKGASLDA GSGEPPMDYH EDDKRFRREE YEGNLLEAGL ELERDEDTKI 
       160        170        180        190        200
HGVGFVKIHA PWNVLCREAE FLKLKMPTKK MYHINETRGL LKKINSVLQK 
       210        220        230        240        250
ITDPIQPKVA EHRPQTMKRL SYPFSREKQH LFDLSDKDSF FDSKTRSTIV 
       260        270        280        290        300
YEILKRTTCT KAKYSMGITS LLANGVYAAA YPLHDGDYNG ENVEFNDRKL 
       310        320        330        340        350
LYEEWARYGV FYKYQPIDLV RKYFGEKIGL YFAWLGVYTQ MLIPASIVGI 
       360        370        380        390        400
IVFLYGCATM DENIPSMEMC DQRHNITMCP LCDKTCSYWK MSSACATARA 
       410        420        430        440        450
SHLFDNPATV FFSVFMALWA ATFMEHWKRK QMRLNYRWDL TGFEEEEEAV 
       460        470        480        490        500
KDHPRAEYEA RVLEKSLKKE SRNKEKRRHI PEESTNKWKQ RVKTAMAGVK 
       510        520        530        540        550
LTDKVKLTWR DRFPAYLTNL VSIIFMIAVT FAIVLGVIIY RISMAAALAM 
       560        570        580        590        600
NSSPSVRSNI RVTVTATAVI INLVVIILLD EVYGCIARWL TKIEVPKTEK 
       610        620        630        640        650
SFEERLIFKA FLLKFVNSYT PIFYVAFFKG RFVGRPGDYV YIFRSFRMEE 
       660        670        680        690        700
CAPGGCLMEL CIQLSIIMLG KQLIQNNLFE IGIPKMKKLI RYLKLKQQSP 
       710        720        730        740        750
PDHEECVKRK QRYEVDYNLE PFAGLTPEYM EMIIQFGFVT LFVASFPLAP 
       760        770        780        790        800
LFALLNNIIE IRLDAKKFVT ELRRPVAVRA KDIGIWYNIL RGIGKLAVII 
       810        820        830        840        850
NAFVISFTSD FIPRLVYLYM YSKNGTMHGF VNHTLSSFNV SDFQNGTAPN 
       860        870        880        890        900
DPLDLGYEVQ ICRYKDYREP PWSENKYDIS KDFWAVLAAR LAFVIVFQNL 
       910        920        930        940        950
VMFMSDFVDW VIPDIPKDIS QQIHKEKVLM VELFMREEQD KQQLLETWME 
       960        970        980 
KERQKDEPPC NHHNTKACPD SLGSPAPSHA YHGGVL

Length:986

Mass (Da):114,078

Last modified:November 23, 2004 - v1

Checksum:ⁱE30A02F91EF36FC2

Isoform 2 (identifier: Q5XXA6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     448-451: Missing.
     476-501: Missing.

« Hide

        10         20         30         40         50
MDYHEDDKRF RREEYEGNLL EAGLELERDE DTKIHGVGFV KIHAPWNVLC 
        60         70         80         90        100
REAEFLKLKM PTKKMYHINE TRGLLKKINS VLQKITDPIQ PKVAEHRPQT 
       110        120        130        140        150
MKRLSYPFSR EKQHLFDLSD KDSFFDSKTR STIVYEILKR TTCTKAKYSM 
       160        170        180        190        200
GITSLLANGV YAAAYPLHDG DYNGENVEFN DRKLLYEEWA RYGVFYKYQP 
       210        220        230        240        250
IDLVRKYFGE KIGLYFAWLG VYTQMLIPAS IVGIIVFLYG CATMDENIPS 
       260        270        280        290        300
MEMCDQRHNI TMCPLCDKTC SYWKMSSACA TARASHLFDN PATVFFSVFM 
       310        320        330        340        350
ALWAATFMEH WKRKQMRLNY RWDLTGFEEE EDHPRAEYEA RVLEKSLKKE 
       360        370        380        390        400
SRNKETDKVK LTWRDRFPAY LTNLVSIIFM IAVTFAIVLG VIIYRISMAA 
       410        420        430        440        450
ALAMNSSPSV RSNIRVTVTA TAVIINLVVI ILLDEVYGCI ARWLTKIEVP 
       460        470        480        490        500
KTEKSFEERL IFKAFLLKFV NSYTPIFYVA FFKGRFVGRP GDYVYIFRSF 
       510        520        530        540        550
RMEECAPGGC LMELCIQLSI IMLGKQLIQN NLFEIGIPKM KKLIRYLKLK 
       560        570        580        590        600
QQSPPDHEEC VKRKQRYEVD YNLEPFAGLT PEYMEMIIQF GFVTLFVASF 
       610        620        630        640        650
PLAPLFALLN NIIEIRLDAK KFVTELRRPV AVRAKDIGIW YNILRGIGKL 
       660        670        680        690        700
AVIINAFVIS FTSDFIPRLV YLYMYSKNGT MHGFVNHTLS SFNVSDFQNG 
       710        720        730        740        750
TAPNDPLDLG YEVQICRYKD YREPPWSENK YDISKDFWAV LAARLAFVIV 
       760        770        780        790        800
FQNLVMFMSD FVDWVIPDIP KDISQQIHKE KVLMVELFMR EEQDKQQLLE 
       810        820        830        840
TWMEKERQKD EPPCNHHNTK ACPDSLGSPA PSHAYHGGVL

Note: No experimental confirmation available.

Show »

Length:840

Mass (Da):97,736

Checksum:ⁱ43B0D18B6FD82C3A

Isoform 3 (identifier: Q5XXA6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     29-36: GYLPSEGT → MLTRPSQV
     448-451: Missing.
     476-501: Missing.
     651-700: CAPGGCLMEL...RYLKLKQQSP → VTEILFISGS...SFLLETFLFP
     701-986: Missing.

« Hide

        10         20         30         40         50
MLTRPSQVLL NSLSVDPDAE CKYGLYFRDG RRKVDYILVY HHKRPSGNRT 
        60         70         80         90        100
LVRRVQHSDT PSGARSVKQD HPLPGKGASL DAGSGEPPMD YHEDDKRFRR 
       110        120        130        140        150
EEYEGNLLEA GLELERDEDT KIHGVGFVKI HAPWNVLCRE AEFLKLKMPT 
       160        170        180        190        200
KKMYHINETR GLLKKINSVL QKITDPIQPK VAEHRPQTMK RLSYPFSREK 
       210        220        230        240        250
QHLFDLSDKD SFFDSKTRST IVYEILKRTT CTKAKYSMGI TSLLANGVYA 
       260        270        280        290        300
AAYPLHDGDY NGENVEFNDR KLLYEEWARY GVFYKYQPID LVRKYFGEKI 
       310        320        330        340        350
GLYFAWLGVY TQMLIPASIV GIIVFLYGCA TMDENIPSME MCDQRHNITM 
       360        370        380        390        400
CPLCDKTCSY WKMSSACATA RASHLFDNPA TVFFSVFMAL WAATFMEHWK 
       410        420        430        440        450
RKQMRLNYRW DLTGFEEEED HPRAEYEARV LEKSLKKESR NKETDKVKLT 
       460        470        480        490        500
WRDRFPAYLT NLVSIIFMIA VTFAIVLGVI IYRISMAAAL AMNSSPSVRS 
       510        520        530        540        550
NIRVTVTATA VIINLVVIIL LDEVYGCIAR WLTKIEVPKT EKSFEERLIF 
       560        570        580        590        600
KAFLLKFVNS YTPIFYVAFF KGRFVGRPGD YVYIFRSFRM EEVTEILFIS 
       610        620        630        640 
GSPFCLAYDL STPCTWEKQL QHICSAKSSR FLSFLLETFL FP

Note: No experimental confirmation available.

Show »

Length:642

Mass (Da):74,369

Checksum:ⁱ6F7B524B54FD032B

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PNA7	E9PNA7_HUMAN	Anoctamin Anoctamin	ANO1	695	Annotation score:
H0YDD9	H0YDD9_HUMAN	Anoctamin Anoctamin	ANO1	269	Annotation score:
E9PS90	E9PS90_HUMAN	Anoctamin Anoctamin	ANO1	151	Annotation score:
E9PP68	E9PP68_HUMAN	Anoctamin-1 Anoctamin-1	ANO1	251	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	202	T → A in BAF85777 (PubMed:14702039).Curated	1
Sequence conflictⁱ	801	N → D in AAH33036 (PubMed:15489334).Curated	1
Sequence conflictⁱ	948	W → C in AAH33036 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032417	608	F → S. Corresponds to variant dbSNP:rs2186797Ensembl.		1
Natural variantⁱVAR_032418	983	G → R. Corresponds to variant dbSNP:rs3740722Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_025665	1 – 116	Missing in isoform 2. 1 PublicationAdd BLAST	116
Alternative sequenceⁱVSP_025666	1 – 28	Missing in isoform 3. 1 PublicationAdd BLAST	28
Alternative sequenceⁱVSP_025667	29 – 36	GYLPSEGT → MLTRPSQV in isoform 3. 1 Publication	8
Alternative sequenceⁱVSP_025668	448 – 451	Missing in isoform 2 and isoform 3. 2 Publications	4
Alternative sequenceⁱVSP_025669	476 – 501	Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	26
Alternative sequenceⁱVSP_025670	651 – 700	CAPGG…KQQSP → VTEILFISGSPFCLAYDLST PCTWEKQLQHICSAKSSRFL SFLLETFLFP in isoform 3. 1 PublicationAdd BLAST	50
Alternative sequenceⁱVSP_025671	701 – 986	Missing in isoform 3. 1 PublicationAdd BLAST	286

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY728143 mRNA Translation: AAU82085.1 AK097619 mRNA Translation: BAC05123.1 AK293088 mRNA Translation: BAF85777.1 BC033036 mRNA Translation: AAH33036.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44663.1 [Q5XXA6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_060513.5, NM_018043.5 [Q5XXA6-1] XP_006718668.1, XM_006718605.2 [Q5XXA6-2] XP_011543433.1, XM_011545131.2 [Q5XXA6-3]
UniGeneⁱ	Hs.503074

Genome annotation databases

Ensemblⁱ	ENST00000316296; ENSP00000319477; ENSG00000131620 [Q5XXA6-3] ENST00000355303; ENSP00000347454; ENSG00000131620 [Q5XXA6-1] ENST00000530676; ENSP00000435797; ENSG00000131620 [Q5XXA6-2]
GeneIDⁱ	55107
KEGGⁱ	hsa:55107
UCSC genome browser More...UCSCⁱ	uc001opj.4 human [Q5XXA6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5XXA6	Anoctamin		MESAU		1021	UniRef90_Q5XXA6
Anoctamin		PONAB		986
Anoctamin		RHIRO		986
Anoctamin		GORGO		986
Anoctamin		LOXAF		979
+19
Q5XXA6-2	Anoctamin-1	)	MOUSE		960	UniRef90_Q8BHY3
Anoctamin		MESAU		1017
Anoctamin		NEOSC		966
Anoctamin		PHYCD		954
Anoctamin		LOXAF		952
+90
Q5XXA6-3	Anoctamin		PANTR		642	UniRef90_Q5XXA6-3
Anoctamin		MACMU		642
Anoctamin		GORGO		640
Anoctamin		AOTNA		632
Anoctamin		CERAT		624
+3

Protein	Similar proteins		Species	Score	Length	Source
Q5XXA6	Anoctamin-1	)	MOUSE		960	UniRef50_Q8BHY3
Anoctamin		MESAU		1017
Anoctamin		NEOSC		966
Anoctamin		PHYCD		954
Anoctamin		LOXAF		952
+936
Q5XXA6-3	Anoctamin		MACMU		642	UniRef50_Q5XXA6-3
Anoctamin		PANTR		642
Anoctamin		GORGO		640
Anoctamin		AOTNA		632
Anoctamin		CERAT		624
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY728143 mRNA Translation: AAU82085.1 AK097619 mRNA Translation: BAC05123.1 AK293088 mRNA Translation: BAF85777.1 BC033036 mRNA Translation: AAH33036.2
CCDSⁱ	CCDS44663.1 [Q5XXA6-1]
RefSeqⁱ	NP_060513.5, NM_018043.5 [Q5XXA6-1] XP_006718668.1, XM_006718605.2 [Q5XXA6-2] XP_011543433.1, XM_011545131.2 [Q5XXA6-3]
UniGeneⁱ	Hs.503074

3D structure databases

ProteinModelPortalⁱ	Q5XXA6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120417, 1 interactor
IntActⁱ	Q5XXA6, 1 interactor
STRINGⁱ	9606.ENSP00000347454

Chemistry databases

BindingDBⁱ	Q5XXA6
ChEMBLⁱ	CHEMBL2046267
DrugBankⁱ	DB04941 Crofelemer
GuidetoPHARMACOLOGYⁱ	708

Protein family/group databases

TCDBⁱ	1.A.17.1.1 the calcium-dependent chloride channel (ca-clc) family

TCDBⁱ

1.A.17.1.1 the calcium-dependent chloride channel (ca-clc) family

PTM databases

iPTMnetⁱ	Q5XXA6
PhosphoSitePlusⁱ	Q5XXA6

Polymorphism and mutation databases

BioMutaⁱ	ANO1
DMDMⁱ	74708278

Proteomic databases

EPDⁱ	Q5XXA6
MaxQBⁱ	Q5XXA6
PaxDbⁱ	Q5XXA6
PeptideAtlasⁱ	Q5XXA6
PRIDEⁱ	Q5XXA6
ProteomicsDBⁱ	65854 65855 [Q5XXA6-2] 65856 [Q5XXA6-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000316296; ENSP00000319477; ENSG00000131620 [Q5XXA6-3] ENST00000355303; ENSP00000347454; ENSG00000131620 [Q5XXA6-1] ENST00000530676; ENSP00000435797; ENSG00000131620 [Q5XXA6-2]
GeneIDⁱ	55107
KEGGⁱ	hsa:55107
UCSCⁱ	uc001opj.4 human [Q5XXA6-1]

Organism-specific databases

CTDⁱ	55107
DisGeNETⁱ	55107
EuPathDBⁱ	HostDB:ENSG00000131620.17
GeneCardsⁱ	ANO1
HGNCⁱ	HGNC:21625 ANO1
HPAⁱ	HPA032148 HPA057356
MIMⁱ	610108 gene
neXtProtⁱ	NX_Q5XXA6
OpenTargetsⁱ	ENSG00000131620
PharmGKBⁱ	PA164715378
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2514 Eukaryota ENOG410XS4S LUCA
GeneTreeⁱ	ENSGT00760000119015
HOGENOMⁱ	HOG000006509
HOVERGENⁱ	HBG069519
InParanoidⁱ	Q5XXA6
KOⁱ	K19496
OMAⁱ	LYMYSEN
OrthoDBⁱ	EOG091G01JF
PhylomeDBⁱ	Q5XXA6
TreeFamⁱ	TF314265

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2672351 Stimuli-sensing channels

Reactomeⁱ

R-HSA-2672351 Stimuli-sensing channels

Miscellaneous databases

ChiTaRSⁱ	ANO1 human
GeneWikiⁱ	ANO1
GenomeRNAiⁱ	55107
Protein Ontology More...PROⁱ	PR:Q5XXA6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131620 Expressed in 164 organ(s), highest expression level in thoracic aorta
CleanExⁱ	HS_ANO1
ExpressionAtlasⁱ	Q5XXA6 baseline and differential
Genevisibleⁱ	Q5XXA6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR032394 Anoct_dimer IPR007632 Anoctamin IPR031287 Anoctamin-1
PANTHERⁱ	PTHR12308 PTHR12308, 1 hit PTHR12308:SF13 PTHR12308:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF16178 Anoct_dimer, 1 hit PF04547 Anoctamin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANO1_HUMAN
Accessionⁱ	Q5XXA6Primary (citable) accession number: Q5XXA6 Secondary accession number(s): A8KAM3, Q8IYY8, Q8N7V3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
	Last sequence update:	November 23, 2004
	Last modified:	November 7, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q5XXA6 (ANO1_HUMAN)

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Anoctamin-1

ANO1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ