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UniProtKB - Q5XXA6 (ANO1_HUMAN)

Entry version 140 (29 Sep 2021)
Sequence version 1 (23 Nov 2004)
Previous versions | rss
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Protein

Anoctamin-1

Gene

ANO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

4 Publications

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.Curated

Caution

Contains ten transmembrane regions, not eight as predicted.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi677Calcium 1By similarity1
Metal bindingi680Calcium 2By similarity1
Metal bindingi728Calcium 2By similarity1
Metal bindingi731Calcium 1By similarity1
Metal bindingi760Calcium 1By similarity1
Metal bindingi764Calcium 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Developmental protein, Ion channel
Biological processIon transport, Transport
LigandCalcium, Chloride, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5XXA6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2672351, Stimuli-sensing channels

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.17.1.1, the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anoctamin-1
Alternative name(s):
Discovered on gastrointestinal stromal tumors protein 1
Oral cancer overexpressed protein 2
Transmembrane protein 16A
Tumor-amplified and overexpressed sequence 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANO1
Synonyms:DOG11 Publication, ORAOV2, TAOS2, TMEM16A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21625, ANO1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610108, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5XXA6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131620

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 333CytoplasmicCuratedAdd BLAST333
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei334 – 354HelicalBy similarityAdd BLAST21
Topological domaini355 – 406ExtracellularCuratedAdd BLAST52
Transmembranei407 – 427HelicalBy similarityAdd BLAST21
Topological domaini428 – 519CytoplasmicCuratedAdd BLAST92
Transmembranei520 – 540HelicalBy similarityAdd BLAST21
Topological domaini541 – 568ExtracellularCuratedAdd BLAST28
Transmembranei569 – 589HelicalBy similarityAdd BLAST21
Topological domaini590 – 607CytoplasmicCuratedAdd BLAST18
Transmembranei608 – 628HelicalBy similarityAdd BLAST21
Topological domaini629 – 657ExtracellularCuratedAdd BLAST29
Transmembranei658 – 678HelicalBy similarityAdd BLAST21
Topological domaini679 – 725CytoplasmicCuratedAdd BLAST47
Transmembranei726 – 746HelicalBy similarityAdd BLAST21
Transmembranei747 – 767HelicalBy similarityAdd BLAST21
Topological domaini768 – 784CytoplasmicCuratedAdd BLAST17
Transmembranei785 – 805HelicalBy similarityAdd BLAST21
Topological domaini806 – 892ExtracellularCuratedAdd BLAST87
Transmembranei893 – 913HelicalBy similarityAdd BLAST21
Topological domaini914 – 986CytoplasmicCuratedAdd BLAST73

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55107

Open Targets

More...OpenTargetsi		ENSG00000131620

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164715378

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5XXA6, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2046267

Drug and drug target database

More...DrugBanki		DB04941, Crofelemer

DrugCentral

More...DrugCentrali		Q5XXA6

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		708

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ANO1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74708278

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002884351 – 986Anoctamin-1Add BLAST986

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei107PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi370 ↔ 395By similarity
Disulfide bondi379 ↔ 862By similarity
Disulfide bondi382 ↔ 386By similarity
Disulfide bondi651 ↔ 656By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi832N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5XXA6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5XXA6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5XXA6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5XXA6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5XXA6

PeptideAtlas

More...PeptideAtlasi		Q5XXA6

PRoteomics IDEntifications database

More...PRIDEi		Q5XXA6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		65854 [Q5XXA6-1]
65855 [Q5XXA6-2]
65856 [Q5XXA6-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q5XXA6, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5XXA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5XXA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131620, Expressed in thoracic aorta and 182 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5XXA6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5XXA6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131620, Group enriched (ductus deferens, epididymis, salivary gland, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:21056985).

Interacts with CFTR (PubMed:22178883).

Interacts with TRPV4 (By similarity).

By similarity2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120417, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q5XXA6, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347454

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q5XXA6

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5XXA6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 121DisorderedSequence analysisAdd BLAST43
Regioni951 – 986DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 93Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anoctamin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2514, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157182

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006685_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5XXA6

Identification of Orthologs from Complete Genome Data

More...OMAi		QMDYHED

Database of Orthologous Groups

More...OrthoDBi		1263362at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5XXA6

TreeFam database of animal gene trees

More...TreeFami		TF314265

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032394, Anoct_dimer
IPR007632, Anoctamin
IPR031287, Anoctamin-1

The PANTHER Classification System

More...PANTHERi		PTHR12308, PTHR12308, 1 hit
PTHR12308:SF13, PTHR12308:SF13, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16178, Anoct_dimer, 1 hit
PF04547, Anoctamin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5XXA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVNEKYSTL PAEDRSVHII NICAIEDIGY LPSEGTLLNS LSVDPDAECK 
        60         70         80         90        100
YGLYFRDGRR KVDYILVYHH KRPSGNRTLV RRVQHSDTPS GARSVKQDHP 
       110        120        130        140        150
LPGKGASLDA GSGEPPMDYH EDDKRFRREE YEGNLLEAGL ELERDEDTKI 
       160        170        180        190        200
HGVGFVKIHA PWNVLCREAE FLKLKMPTKK MYHINETRGL LKKINSVLQK 
       210        220        230        240        250
ITDPIQPKVA EHRPQTMKRL SYPFSREKQH LFDLSDKDSF FDSKTRSTIV 
       260        270        280        290        300
YEILKRTTCT KAKYSMGITS LLANGVYAAA YPLHDGDYNG ENVEFNDRKL 
       310        320        330        340        350
LYEEWARYGV FYKYQPIDLV RKYFGEKIGL YFAWLGVYTQ MLIPASIVGI 
       360        370        380        390        400
IVFLYGCATM DENIPSMEMC DQRHNITMCP LCDKTCSYWK MSSACATARA 
       410        420        430        440        450
SHLFDNPATV FFSVFMALWA ATFMEHWKRK QMRLNYRWDL TGFEEEEEAV 
       460        470        480        490        500
KDHPRAEYEA RVLEKSLKKE SRNKEKRRHI PEESTNKWKQ RVKTAMAGVK 
       510        520        530        540        550
LTDKVKLTWR DRFPAYLTNL VSIIFMIAVT FAIVLGVIIY RISMAAALAM 
       560        570        580        590        600
NSSPSVRSNI RVTVTATAVI INLVVIILLD EVYGCIARWL TKIEVPKTEK 
       610        620        630        640        650
SFEERLIFKA FLLKFVNSYT PIFYVAFFKG RFVGRPGDYV YIFRSFRMEE 
       660        670        680        690        700
CAPGGCLMEL CIQLSIIMLG KQLIQNNLFE IGIPKMKKLI RYLKLKQQSP 
       710        720        730        740        750
PDHEECVKRK QRYEVDYNLE PFAGLTPEYM EMIIQFGFVT LFVASFPLAP 
       760        770        780        790        800
LFALLNNIIE IRLDAKKFVT ELRRPVAVRA KDIGIWYNIL RGIGKLAVII 
       810        820        830        840        850
NAFVISFTSD FIPRLVYLYM YSKNGTMHGF VNHTLSSFNV SDFQNGTAPN 
       860        870        880        890        900
DPLDLGYEVQ ICRYKDYREP PWSENKYDIS KDFWAVLAAR LAFVIVFQNL 
       910        920        930        940        950
VMFMSDFVDW VIPDIPKDIS QQIHKEKVLM VELFMREEQD KQQLLETWME 
       960        970        980 
KERQKDEPPC NHHNTKACPD SLGSPAPSHA YHGGVL
Length:986
Mass (Da):114,078
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE30A02F91EF36FC2
GO
Isoform 2 (identifier: Q5XXA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     448-451: Missing.
     476-501: Missing.

Show »
Length:840
Mass (Da):97,736
Checksum:i43B0D18B6FD82C3A
GO
Isoform 3 (identifier: Q5XXA6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     29-36: GYLPSEGT → MLTRPSQV
     448-451: Missing.
     476-501: Missing.
     651-700: CAPGGCLMEL...RYLKLKQQSP → VTEILFISGS...SFLLETFLFP
     701-986: Missing.

Show »
Length:642
Mass (Da):74,369
Checksum:i6F7B524B54FD032B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNA7E9PNA7_HUMAN
Anoctamin
ANO1
695Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDD9H0YDD9_HUMAN
Anoctamin
ANO1
269Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP68E9PP68_HUMAN
Anoctamin-1
ANO1
251Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS90E9PS90_HUMAN
Anoctamin
ANO1
151Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202T → A in BAF85777 (PubMed:14702039).Curated1
Sequence conflicti801N → D in AAH33036 (PubMed:15489334).Curated1
Sequence conflicti948W → C in AAH33036 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032417608F → S. Corresponds to variant dbSNP:rs2186797Ensembl.1
Natural variantiVAR_032418983G → R. Corresponds to variant dbSNP:rs3740722Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0256651 – 116Missing in isoform 2. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_0256661 – 28Missing in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_02566729 – 36GYLPSEGT → MLTRPSQV in isoform 3. 1 Publication8
Alternative sequenceiVSP_025668448 – 451Missing in isoform 2 and isoform 3. 2 Publications4
Alternative sequenceiVSP_025669476 – 501Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_025670651 – 700CAPGG…KQQSP → VTEILFISGSPFCLAYDLST PCTWEKQLQHICSAKSSRFL SFLLETFLFP in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_025671701 – 986Missing in isoform 3. 1 PublicationAdd BLAST286

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY728143 mRNA Translation: AAU82085.1
AK097619 mRNA Translation: BAC05123.1
AK293088 mRNA Translation: BAF85777.1
BC033036 mRNA Translation: AAH33036.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44663.1 [Q5XXA6-1]

NCBI Reference Sequences

More...RefSeqi		NP_060513.5, NM_018043.5 [Q5XXA6-1]
XP_006718668.1, XM_006718605.2 [Q5XXA6-2]
XP_011543433.1, XM_011545131.2 [Q5XXA6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000316296; ENSP00000319477; ENSG00000131620 [Q5XXA6-3]
ENST00000355303; ENSP00000347454; ENSG00000131620 [Q5XXA6-1]
ENST00000530676; ENSP00000435797; ENSG00000131620 [Q5XXA6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55107

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55107

UCSC genome browser

More...UCSCi		uc001opj.4, human [Q5XXA6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY728143 mRNA Translation: AAU82085.1
AK097619 mRNA Translation: BAC05123.1
AK293088 mRNA Translation: BAF85777.1
BC033036 mRNA Translation: AAH33036.2
CCDSiCCDS44663.1 [Q5XXA6-1]
RefSeqiNP_060513.5, NM_018043.5 [Q5XXA6-1]
XP_006718668.1, XM_006718605.2 [Q5XXA6-2]
XP_011543433.1, XM_011545131.2 [Q5XXA6-3]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120417, 2 interactors
IntActiQ5XXA6, 2 interactors
STRINGi9606.ENSP00000347454

Chemistry databases

BindingDBiQ5XXA6
ChEMBLiCHEMBL2046267
DrugBankiDB04941, Crofelemer
DrugCentraliQ5XXA6
GuidetoPHARMACOLOGYi708

Protein family/group databases

TCDBi1.A.17.1.1, the calcium-dependent chloride channel (ca-clc) family

PTM databases

GlyGeniQ5XXA6, 1 site
iPTMnetiQ5XXA6
PhosphoSitePlusiQ5XXA6

Genetic variation databases

BioMutaiANO1
DMDMi74708278

Proteomic databases

EPDiQ5XXA6
jPOSTiQ5XXA6
MassIVEiQ5XXA6
MaxQBiQ5XXA6
PaxDbiQ5XXA6
PeptideAtlasiQ5XXA6
PRIDEiQ5XXA6
ProteomicsDBi65854 [Q5XXA6-1]
65855 [Q5XXA6-2]
65856 [Q5XXA6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30667, 1342 antibodies

The DNASU plasmid repository

More...DNASUi		55107

Genome annotation databases

EnsembliENST00000316296; ENSP00000319477; ENSG00000131620 [Q5XXA6-3]
ENST00000355303; ENSP00000347454; ENSG00000131620 [Q5XXA6-1]
ENST00000530676; ENSP00000435797; ENSG00000131620 [Q5XXA6-2]
GeneIDi55107
KEGGihsa:55107
UCSCiuc001opj.4, human [Q5XXA6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55107
DisGeNETi55107

GeneCards: human genes, protein and diseases

More...GeneCardsi		ANO1
HGNCiHGNC:21625, ANO1
HPAiENSG00000131620, Group enriched (ductus deferens, epididymis, salivary gland, seminal vesicle)
MIMi610108, gene
neXtProtiNX_Q5XXA6
OpenTargetsiENSG00000131620
PharmGKBiPA164715378
VEuPathDBiHostDB:ENSG00000131620

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2514, Eukaryota
GeneTreeiENSGT00940000157182
HOGENOMiCLU_006685_5_2_1
InParanoidiQ5XXA6
OMAiQMDYHED
OrthoDBi1263362at2759
PhylomeDBiQ5XXA6
TreeFamiTF314265

Enzyme and pathway databases

PathwayCommonsiQ5XXA6
ReactomeiR-HSA-2672351, Stimuli-sensing channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55107, 12 hits in 1005 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ANO1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ANO1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55107
PharosiQ5XXA6, Tclin

Protein Ontology

More...PROi		PR:Q5XXA6
RNActiQ5XXA6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131620, Expressed in thoracic aorta and 182 other tissues
ExpressionAtlasiQ5XXA6, baseline and differential
GenevisibleiQ5XXA6, HS

Family and domain databases

InterProiView protein in InterPro
IPR032394, Anoct_dimer
IPR007632, Anoctamin
IPR031287, Anoctamin-1
PANTHERiPTHR12308, PTHR12308, 1 hit
PTHR12308:SF13, PTHR12308:SF13, 1 hit
PfamiView protein in Pfam
PF16178, Anoct_dimer, 1 hit
PF04547, Anoctamin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANO1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5XXA6
Secondary accession number(s): A8KAM3, Q8IYY8, Q8N7V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 23, 2004
Last modified: September 29, 2021
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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