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Protein

Minor nucleoprotein VP30

Gene

VP30

Organism
Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 90C3H1-type; atypicalAdd BLAST19

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, Viral nucleoprotein
Biological processTranscription
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Minor nucleoprotein VP30
Alternative name(s):
Transcription activator VP30
Gene namesi
Name:VP30
OrganismiSudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus)
Taxonomic identifieri386033 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
Proteomesi
  • UP000000277 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002450731 – 288Minor nucleoprotein VP30Add BLAST288

Post-translational modificationi

Phosphorylated by host. Phosphorylation negatively regulates the transcription activation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homohexamer or homodimer. Interacts with the nucleoprotein (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5XX03
SMRiQ5XX03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 44Intrinsically disorderedSequence analysisAdd BLAST44
Regioni26 – 40RNA-bindingBy similarityAdd BLAST15
Regioni94 – 112OligomerizationBy similarityAdd BLAST19
Regioni121 – 140Intrinsically disorderedSequence analysisAdd BLAST20
Regioni180 – 197Interaction with the nucleoproteinBy similarityAdd BLAST18
Regioni268 – 288Intrinsically disorderedSequence analysisAdd BLAST21

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 90C3H1-type; atypicalAdd BLAST19

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OrthoDBiVOG090000JS

Family and domain databases

InterProiView protein in InterPro
IPR014459 VP30_FiloV
PfamiView protein in Pfam
PF11507 Transcript_VP30, 1 hit
PIRSFiPIRSF011356 VP30_FiloV, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XX03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERGRERGRS RNSRADQQNS TGPQFRTRSI SRDKTTTDYR SSRSTSQVRV
60 70 80 90 100
PTVFHKKGTG TLTVPPAPKD VCPTLRKGFL CDSNFCKKDH QLESLTDREL
110 120 130 140 150
LLLIARKTCG STDSSLNIAA PKDLRLANPT ADDFKQDGSP KLTLKLLVET
160 170 180 190 200
AEFWANQNIN EVDDAKLRAL LTLSAVLVRK FSKSQLSQLC ESHLRRENLG
210 220 230 240 250
QDQAESVLEV YQRLHSDKGG AFEAALWQQW DRQSLTMFIS AFLHVALQLS
260 270 280
CESSTVVISG LRLLAPPSVN EGLPPAPGEY TWSEDSTT
Length:288
Mass (Da):32,107
Last modified:November 23, 2004 - v1
Checksum:i456599DB1654839E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY729654 Genomic RNA Translation: AAU43888.1
RefSeqiYP_138525.1, NC_006432.1

Genome annotation databases

GeneIDi3160773
KEGGivg:3160773

Similar proteinsi

Entry informationi

Entry nameiVP30_EBOSU
AccessioniPrimary (citable) accession number: Q5XX03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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