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Entry version 114 (02 Jun 2021)
Sequence version 1 (23 Nov 2004)
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Protein

Phosphoinositide 5-phosphatase

Gene

synj1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation, RNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoinositide 5-phosphataseARBA annotation (EC:3.1.3.36ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:synj1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-9180, synj1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini119 – 444SACInterPro annotationAdd BLAST326
Domaini899 – 975RRMInterPro annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1032 – 1308DisorderedSequence analysisAdd BLAST277

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1048 – 1077Pro residuesSequence analysisAdd BLAST30
Compositional biasi1095 – 1126Pro residuesSequence analysisAdd BLAST32
Compositional biasi1150 – 1189Pro residuesSequence analysisAdd BLAST40
Compositional biasi1196 – 1214Pro residuesSequence analysisAdd BLAST19
Compositional biasi1222 – 1255Pro residuesSequence analysisAdd BLAST34
Compositional biasi1294 – 1308Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptojanin family.ARBA annotation
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.ARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVAIDCV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5XUX5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015047, DUF1866
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000300, IPPc
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR002013, SAC_dom
IPR034972, SYNJ1

The PANTHER Classification System

More...
PANTHERi
PTHR11200:SF158, PTHR11200:SF158, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08952, DUF1866, 1 hit
PF03372, Exo_endo_phos, 1 hit
PF02383, Syja_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01165, DUF1866, 1 hit
SM00128, IPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit
SSF56219, SSF56219, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 1 hit
PS50275, SAC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5XUX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFSKGYRIY HKLDPPPYSV IVETRNREEC LMFESGAVAV LSAAEKETIK
60 70 80 90 100
ASYTKMLDAY GILGVLRLNL GDSMLHSLVV VTGCSSVGKV QDSEVFRVTG
110 120 130 140 150
TDFVSLKNDP TDEDRIADVR KVLNSGNFYF AWSSTGVSLD LSLNAHRRIR
160 170 180 190 200
EDTSDNRFFW NQSLHLHLKH YGVNCDDWLL RLMCGGVEIR TIYAGHKQAK
210 220 230 240 250
ACVISRLSSE RAGTRFNVRG TNDDGQVANF VETEQIIFLD DKVSSFIQIR
260 270 280 290 300
GSIPLFWEQP GIQVGSHRVK LSRGFEANAP AFERHFSALK RLYGKQLIIN
310 320 330 340 350
LLGMKEGEHM LSKAFQSHLK ASEHSNAVKM LNFDYHQMVK GGKTEKLQTV
360 370 380 390 400
LKPQISKFVE DCDFFYYSGE TGIQRCQSGT IRSNCLDCLD RTNSVQAFIA
410 420 430 440 450
LEMLPKQLEA MGLTEKPQLV ARFQEVFRSM WSTNGDSISK IYAGTGALDG
460 470 480 490 500
KAKGGKLKDG ARSVTRTIQN NFFDSSKQEA IDILRLGSTL NSDLADKARA
510 520 530 540 550
LLTTSSLYVS EPILQSASPR VLLGMCQNHF KYTRPKKIRV CVGTWNVNGG
560 570 580 590 600
KQFRSIAFRN HTLNDWLLDA PKKARHPEFQ DVKNNPVDIF AIGFEEMVEL
610 620 630 640 650
NAGNIVSAST TNQKLWAAEL QKNISRDQRY VLLASEQLVG VCLFVFIRPQ
660 670 680 690 700
HAPFIRDVAV DTVKTGMGGA TGNKGGVAIR MLFHTTSICF VCSHFAAGQS
710 720 730 740 750
QVKERNDDYN EIARKLSFPM GRLLYSHDYV FWCGDFNYRI NIPNEEVKEL
760 770 780 790 800
IRQQNWDALI GGDQLVEQKN AGQVFRGFIE GKLDFAPTYK YDLFSEDYDT
810 820 830 840 850
SEKCRTPAWT DRVLWKRRKW NFDKTAEELE LNVVGAPVNE EEQYPWSPGD
860 870 880 890 900
LKYYGRAELK TSDHRPVVAI IDVDILEVDP EARHQVYKEV IALQGPPDGT
910 920 930 940 950
ILVSLCSSGP DDYFDDALID DLLDKFANFG EVILIRFVEE KMWVTFLEGY
960 970 980 990 1000
SALAALSLSG STVNGKTIDI RLRSPGWIKS LEEEMSVERI CGSIPTSTSS
1010 1020 1030 1040 1050
TLLAENSDLG EEYDMEGDVD EEVEDILPQH LQPGAGMDLS ASPATSPRTS
1060 1070 1080 1090 1100
PCPSPTHGEP APPIRPSRAP PRTAGPPQGS PVDGQPAGAP FSQGLEPKRP
1110 1120 1130 1140 1150
PPPRPNAPPA RPAPPQRPPP PSGRGQATGP APGGIPRPIP PRAGVISVTP
1160 1170 1180 1190 1200
QARPPPPAHP GAPRPTAEVH PGAPRPSPDN HPGAPRPTAE PQSKPSELPL
1210 1220 1230 1240 1250
GPPPTLPGPV RPQMTSPMQP QSVSPVQPPV QPQLPPPIQS QLPPPMQPTL
1260 1270 1280 1290 1300
PAPLMPQQAP QTSAGAGAAA APQPGLASPK PPPRSRSSHA LPPESAPAPT

TQQEQSSG
Length:1,308
Mass (Da):143,854
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB679127DFF47F143
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY736013 mRNA Translation: AAU95736.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY736013 mRNA Translation: AAU95736.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Organism-specific databases

ZFINiZDB-GENE-030131-9180, synj1

Phylogenomic databases

OMAiDVAIDCV
PhylomeDBiQ5XUX5

Family and domain databases

Gene3Di3.30.70.330, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR015047, DUF1866
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000300, IPPc
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR002013, SAC_dom
IPR034972, SYNJ1
PANTHERiPTHR11200:SF158, PTHR11200:SF158, 1 hit
PfamiView protein in Pfam
PF08952, DUF1866, 1 hit
PF03372, Exo_endo_phos, 1 hit
PF02383, Syja_N, 1 hit
SMARTiView protein in SMART
SM01165, DUF1866, 1 hit
SM00128, IPPc, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
SSF56219, SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit
PS50275, SAC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5XUX5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5XUX5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: June 2, 2021
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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