UniProtKB - Q5XKR4 (OTP_HUMAN)
Protein
Homeobox protein orthopedia
Gene
OTP
Organism
Homo sapiens (Human)
Status
Functioni
Probably involved in the differentiation of hypothalamic neuroendocrine cells.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 104 – 163 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- forebrain neuron differentiation Source: Ensembl
- hypothalamus cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- neurohypophysis development Source: Ensembl
- positive regulation of neuroblast proliferation Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q5XKR4 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein orthopedia |
Gene namesi | Name:OTP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8518, OTP |
MIMi | 604529, gene |
neXtProti | NX_Q5XKR4 |
VEuPathDBi | HostDB:ENSG00000171540.7 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nuclear chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23440 |
OpenTargetsi | ENSG00000171540 |
PharmGKBi | PA32844 |
Miscellaneous databases
Pharosi | Q5XKR4, Tbio |
Genetic variation databases
BioMutai | OTP |
DMDMi | 74762283 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292432 | 1 – 325 | Homeobox protein orthopediaAdd BLAST | 325 |
Proteomic databases
MassIVEi | Q5XKR4 |
PaxDbi | Q5XKR4 |
PeptideAtlasi | Q5XKR4 |
PRIDEi | Q5XKR4 |
ProteomicsDBi | 65833 |
PTM databases
iPTMneti | Q5XKR4 |
PhosphoSitePlusi | Q5XKR4 |
Expressioni
Developmental stagei
Present in fetal hypothalamus at 19 weeks of gestation (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000171540, Expressed in hypothalamus and 19 other tissues |
Genevisiblei | Q5XKR4, HS |
Organism-specific databases
HPAi | ENSG00000171540, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Hide detailsQ5XKR4
Protein-protein interaction databases
BioGRIDi | 117008, 8 interactors |
IntActi | Q5XKR4, 8 interactors |
STRINGi | 9606.ENSP00000302814 |
Miscellaneous databases
RNActi | Q5XKR4, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 306 – 319 | OARPROSITE-ProRule annotationAdd BLAST | 14 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 187 – 194 | Poly-Ala | 8 | |
Compositional biasi | 210 – 213 | Poly-Ala | 4 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000159952 |
HOGENOMi | CLU_056068_0_0_1 |
InParanoidi | Q5XKR4 |
OMAi | MLPGEDI |
OrthoDBi | 1243020at2759 |
PhylomeDBi | Q5XKR4 |
TreeFami | TF351614 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR000047, HTH_motif IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5XKR4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSHADLLDA RLGMKDAAEL LGHREAVKCR LGVGGSDPGG HPGDLAPNSD
60 70 80 90 100
PVEGATLLPG EDITTVGSTP ASLAVSAKDP DKQPGPQGGP NPSQAGQQQG
110 120 130 140 150
QQKQKRHRTR FTPAQLNELE RSFAKTHYPD IFMREELALR IGLTESRVQV
160 170 180 190 200
WFQNRRAKWK KRKKTTNVFR APGTLLPTPG LPQFPSAAAA AAAAMGDSLC
210 220 230 240 250
SFHANDTRWA AAAMPGVSQL PLPPALGRQQ AMAQSLSQCS LAAGPPPNSM
260 270 280 290 300
GLSNSLAGSN GAGLQSHLYQ PAFPGMVPAS LPGPSNVSGS PQLCSSPDSS
310 320
DVWRGTSIAS LRRKALEHTV SMSFT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001800 mRNA Translation: AAH01800.1 |
CCDSi | CCDS4039.1 |
RefSeqi | NP_115485.1, NM_032109.2 |
Genome annotation databases
Ensembli | ENST00000306422; ENSP00000302814; ENSG00000171540 |
GeneIDi | 23440 |
KEGGi | hsa:23440 |
UCSCi | uc003kfg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001800 mRNA Translation: AAH01800.1 |
CCDSi | CCDS4039.1 |
RefSeqi | NP_115485.1, NM_032109.2 |
3D structure databases
SMRi | Q5XKR4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117008, 8 interactors |
IntActi | Q5XKR4, 8 interactors |
STRINGi | 9606.ENSP00000302814 |
PTM databases
iPTMneti | Q5XKR4 |
PhosphoSitePlusi | Q5XKR4 |
Genetic variation databases
BioMutai | OTP |
DMDMi | 74762283 |
Proteomic databases
MassIVEi | Q5XKR4 |
PaxDbi | Q5XKR4 |
PeptideAtlasi | Q5XKR4 |
PRIDEi | Q5XKR4 |
ProteomicsDBi | 65833 |
Protocols and materials databases
Antibodypediai | 12584, 137 antibodies |
DNASUi | 23440 |
Genome annotation databases
Ensembli | ENST00000306422; ENSP00000302814; ENSG00000171540 |
GeneIDi | 23440 |
KEGGi | hsa:23440 |
UCSCi | uc003kfg.4, human |
Organism-specific databases
CTDi | 23440 |
DisGeNETi | 23440 |
GeneCardsi | OTP |
HGNCi | HGNC:8518, OTP |
HPAi | ENSG00000171540, Tissue enriched (brain) |
MIMi | 604529, gene |
neXtProti | NX_Q5XKR4 |
OpenTargetsi | ENSG00000171540 |
PharmGKBi | PA32844 |
VEuPathDBi | HostDB:ENSG00000171540.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000159952 |
HOGENOMi | CLU_056068_0_0_1 |
InParanoidi | Q5XKR4 |
OMAi | MLPGEDI |
OrthoDBi | 1243020at2759 |
PhylomeDBi | Q5XKR4 |
TreeFami | TF351614 |
Enzyme and pathway databases
PathwayCommonsi | Q5XKR4 |
Miscellaneous databases
BioGRID-ORCSi | 23440, 6 hits in 897 CRISPR screens |
ChiTaRSi | OTP, human |
GenomeRNAii | 23440 |
Pharosi | Q5XKR4, Tbio |
PROi | PR:Q5XKR4 |
RNActi | Q5XKR4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171540, Expressed in hypothalamus and 19 other tissues |
Genevisiblei | Q5XKR4, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR000047, HTH_motif IPR003654, OAR_dom |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF03826, OAR, 1 hit |
PRINTSi | PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS50803, OAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OTP_HUMAN | |
Accessioni | Q5XKR4Primary (citable) accession number: Q5XKR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | November 23, 2004 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM