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Protein

Protein FAM219B

Gene

FAM219B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM219B
Gene namesi
Name:FAM219B
Synonyms:C15orf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000178761.14
HGNCiHGNC:24695 FAM219B
neXtProtiNX_Q5XKK7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178761
PharmGKBiPA134953632

Polymorphism and mutation databases

BioMutaiFAM219B
DMDMi74736248

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002439301 – 198Protein FAM219BAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5XKK7
MaxQBiQ5XKK7
PaxDbiQ5XKK7
PeptideAtlasiQ5XKK7
PRIDEiQ5XKK7
ProteomicsDBi65827
65828 [Q5XKK7-2]
65829 [Q5XKK7-3]
TopDownProteomicsiQ5XKK7-2 [Q5XKK7-2]

PTM databases

iPTMnetiQ5XKK7
PhosphoSitePlusiQ5XKK7
SwissPalmiQ5XKK7

Expressioni

Gene expression databases

BgeeiENSG00000178761
CleanExiHS_C15orf17
ExpressionAtlasiQ5XKK7 baseline and differential
GenevisibleiQ5XKK7 HS

Organism-specific databases

HPAiHPA048929
HPA058064

Interactioni

Protein-protein interaction databases

BioGridi121433, 8 interactors
IntActiQ5XKK7, 5 interactors
STRINGi9606.ENSP00000350260

Structurei

3D structure databases

ProteinModelPortaliQ5XKK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM219 family.Curated

Phylogenomic databases

eggNOGiENOG410IXTZ Eukaryota
ENOG4111Q12 LUCA
GeneTreeiENSGT00390000000860
HOGENOMiHOG000231704
HOVERGENiHBG095610
InParanoidiQ5XKK7
OMAiCWCCLGD
OrthoDBiEOG091G0SWY
PhylomeDBiQ5XKK7
TreeFamiTF331928

Family and domain databases

InterProiView protein in InterPro
IPR029339 FAM219
PANTHERiPTHR31281 PTHR31281, 1 hit
PfamiView protein in Pfam
PF15260 FAM219A, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5XKK7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAEPSGRA LRLSTPGPRP SGARDRAPGA AGPPSGQIGN RALRLGERTP
60 70 80 90 100
AAVEKRGPYM VTRAPSIQAK LQKHRDLAKA VLRRKGMLGA SPNRPDSSGK
110 120 130 140 150
RSVKFNKGYT ALSQSPDENL VSLDSDSDGE LGSRYSSGYS SAEQVNQDVS
160 170 180 190
RQLLQDGYHL DEIPDDEDLD LIPPKPMASS TCSCCWCCLG DSSSCTLQ
Length:198
Mass (Da):21,103
Last modified:November 23, 2004 - v1
Checksum:i09B6208FA3307A87
GO
Isoform 2 (identifier: Q5XKK7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-113: VKFNKGYTALS → QQAPPPLCQQL
     114-198: Missing.

Note: No experimental confirmation available.
Show »
Length:113
Mass (Da):11,907
Checksum:iFA727488AEE7C172
GO
Isoform 3 (identifier: Q5XKK7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-148: SDGELGSRYSSGYSSAEQVNQD → RPFMYIPGPFSSEQYPFPGWLG
     149-198: Missing.

Show »
Length:148
Mass (Da):15,868
Checksum:iA705A4641C1F9F90
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019499103 – 113VKFNKGYTALS → QQAPPPLCQQL in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_019500114 – 198Missing in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_036115127 – 148SDGEL…QVNQD → RPFMYIPGPFSSEQYPFPGW LG in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_036116149 – 198Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000005 mRNA Translation: BAA92230.1
AK291020 mRNA Translation: BAF83709.1
AK296403 mRNA Translation: BAG59069.1
AC125435 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99292.1
BC015637 mRNA Translation: AAH15637.1
CCDSiCCDS32295.1 [Q5XKK7-1]
RefSeqiNP_001308849.1, NM_001321920.1 [Q5XKK7-1]
NP_001308850.1, NM_001321921.1 [Q5XKK7-1]
NP_065180.1, NM_020447.4 [Q5XKK7-1]
UniGeneiHs.367690

Genome annotation databases

EnsembliENST00000357635; ENSP00000350260; ENSG00000178761 [Q5XKK7-1]
ENST00000563069; ENSP00000457594; ENSG00000178761 [Q5XKK7-3]
ENST00000563119; ENSP00000454719; ENSG00000178761 [Q5XKK7-1]
GeneIDi57184
KEGGihsa:57184
UCSCiuc002azf.4 human [Q5XKK7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiF219B_HUMAN
AccessioniPrimary (citable) accession number: Q5XKK7
Secondary accession number(s): A8K4Q5, B4DK57, Q9NXY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: July 18, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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