Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type II cytoskeletal 79

Gene

KRT79

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei395Stutter1

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • structural molecule activity Source: InterPro

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 79
Alternative name(s):
Cytokeratin-79
Short name:
CK-79
Keratin-6-like
Short name:
Keratin-6L
Keratin-79
Short name:
K79
Type-II keratin Kb38
Gene namesi
Name:KRT79
Synonyms:K6L, KB38, KRT6L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185640.5
HGNCiHGNC:28930 KRT79
MIMi611160 gene
neXtProtiNX_Q5XKE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185640
PharmGKBiPA162393725

Polymorphism and mutation databases

BioMutaiKRT79
DMDMi296434550

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148931 – 535Keratin, type II cytoskeletal 79Add BLAST535

Proteomic databases

EPDiQ5XKE5
PaxDbiQ5XKE5
PeptideAtlasiQ5XKE5
PRIDEiQ5XKE5
ProteomicsDBi65826

PTM databases

iPTMnetiQ5XKE5
PhosphoSitePlusiQ5XKE5
SwissPalmiQ5XKE5

Expressioni

Tissue specificityi

Expressed in skeletal muscle, skin and scalp, but not in any other tissues or organs examined.1 Publication

Gene expression databases

BgeeiENSG00000185640 Expressed in 47 organ(s), highest expression level in mammalian vulva
CleanExiHS_KRT79
ExpressionAtlasiQ5XKE5 baseline and differential
GenevisibleiQ5XKE5 HS

Organism-specific databases

HPAiHPA059347

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130796, 22 interactors
IntActiQ5XKE5, 28 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5XKE5
SMRiQ5XKE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 457IF rodPROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 141HeadAdd BLAST141
Regioni142 – 177Coil 1AAdd BLAST36
Regioni178 – 198Linker 1Add BLAST21
Regioni199 – 290Coil 1BAdd BLAST92
Regioni291 – 314Linker 12Add BLAST24
Regioni315 – 453Coil 2Add BLAST139
Regioni454 – 535TailAdd BLAST82

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEK5 Eukaryota
ENOG410XUTQ LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ5XKE5
KOiK07605
OMAiAVKKQCQ
OrthoDBiEOG091G09KR
PhylomeDBiQ5XKE5
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 2 hits
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5XKE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSSVSRQTY STKGGFSSNS ASGGSGSQAR TSFSSVTVSR SSGSGGGAHC
60 70 80 90 100
GPGTGGFGSR SLYNLGGHKS ISVSVAGGAL LGRALGGFGF GSRAFMGQGA
110 120 130 140 150
GRQTFGPACP PGGIQEVTVN QSLLTPLHVE IDPEIQRVRT QEREQIKTLN
160 170 180 190 200
NKFASFIDKV RFLEQQNKVL ETKWALLQEQ GQNLGVTRNN LEPLFEAYLG
210 220 230 240 250
SMRSTLDRLQ SERGRLDSEL RNVQDLVEDF KNKYEDEINK HTAAENEFVV
260 270 280 290 300
LKKDVDAAYM GRMDLHGKVG TLTQEIDFLQ QLYEMELSQV QTHVSNTNVV
310 320 330 340 350
LSMDNNRNLD LDSIIAEVKA QYELIAQRSR AEAEAWYQTK YEELQVTAGK
360 370 380 390 400
HGDNLRDTKN EIAELTRTIQ RLQGEADAAK KQCQQLQTAI AEAEQRGELA
410 420 430 440 450
LKDAQKKLGD LDVALHQAKE DLTRLLRDYQ ELMNVKLALD VEIATYRKLL
460 470 480 490 500
ESEESRMSGE CPSAVSISVT GNSTTVCGGG AASFGGGISL GGSGGATKGG
510 520 530
FSTNVGYSTV KGGPVSAGTS ILRKTTTVKT SSQRY
Length:535
Mass (Da):57,836
Last modified:May 18, 2010 - v2
Checksum:iB25A71327186A1C4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YID6H0YID6_HUMAN
Keratin, type II cytoskeletal 79
KRT79
119Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03811381L → S2 PublicationsCorresponds to variant dbSNP:rs2638497Ensembl.1
Natural variantiVAR_038114195F → L1 PublicationCorresponds to variant dbSNP:rs17855862Ensembl.1
Natural variantiVAR_038115266H → R. Corresponds to variant dbSNP:rs17688672Ensembl.1
Natural variantiVAR_038116393A → V. Corresponds to variant dbSNP:rs17688627Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564105 mRNA Translation: CAD91893.1
AC107016 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96648.1
BC039148 mRNA Translation: AAH39148.1
BC063648 mRNA Translation: AAH63648.1
BK000976 Genomic DNA Translation: DAA00403.1
CCDSiCCDS8839.1
RefSeqiNP_787028.1, NM_175834.2
UniGeneiHs.711471

Genome annotation databases

EnsembliENST00000330553; ENSP00000328358; ENSG00000185640
GeneIDi338785
KEGGihsa:338785
UCSCiuc001sbb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564105 mRNA Translation: CAD91893.1
AC107016 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96648.1
BC039148 mRNA Translation: AAH39148.1
BC063648 mRNA Translation: AAH63648.1
BK000976 Genomic DNA Translation: DAA00403.1
CCDSiCCDS8839.1
RefSeqiNP_787028.1, NM_175834.2
UniGeneiHs.711471

3D structure databases

ProteinModelPortaliQ5XKE5
SMRiQ5XKE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130796, 22 interactors
IntActiQ5XKE5, 28 interactors

PTM databases

iPTMnetiQ5XKE5
PhosphoSitePlusiQ5XKE5
SwissPalmiQ5XKE5

Polymorphism and mutation databases

BioMutaiKRT79
DMDMi296434550

Proteomic databases

EPDiQ5XKE5
PaxDbiQ5XKE5
PeptideAtlasiQ5XKE5
PRIDEiQ5XKE5
ProteomicsDBi65826

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330553; ENSP00000328358; ENSG00000185640
GeneIDi338785
KEGGihsa:338785
UCSCiuc001sbb.4 human

Organism-specific databases

CTDi338785
EuPathDBiHostDB:ENSG00000185640.5
GeneCardsiKRT79
H-InvDBiHIX0201906
HGNCiHGNC:28930 KRT79
HPAiHPA059347
MIMi611160 gene
neXtProtiNX_Q5XKE5
OpenTargetsiENSG00000185640
PharmGKBiPA162393725
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEK5 Eukaryota
ENOG410XUTQ LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ5XKE5
KOiK07605
OMAiAVKKQCQ
OrthoDBiEOG091G09KR
PhylomeDBiQ5XKE5
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

GeneWikiiKRT79
GenomeRNAii338785
PROiPR:Q5XKE5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185640 Expressed in 47 organ(s), highest expression level in mammalian vulva
CleanExiHS_KRT79
ExpressionAtlasiQ5XKE5 baseline and differential
GenevisibleiQ5XKE5 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 2 hits
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK2C79_HUMAN
AccessioniPrimary (citable) accession number: Q5XKE5
Secondary accession number(s): Q6P465, Q7Z793
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again