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Protein

Myosin-binding protein C, fast-type

Gene

Mybpc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Muscle protein
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein C, fast-type
Short name:
Fast MyBP-C
Alternative name(s):
C-protein, skeletal muscle fast isoform
Gene namesi
Name:Mybpc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1336170 Mybpc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002530511 – 1136Myosin-binding protein C, fast-typeAdd BLAST1136

Proteomic databases

MaxQBiQ5XKE0
PaxDbiQ5XKE0
PeptideAtlasiQ5XKE0
PRIDEiQ5XKE0

PTM databases

CarbonylDBiQ5XKE0
iPTMnetiQ5XKE0
PhosphoSitePlusiQ5XKE0

Expressioni

Gene expression databases

BgeeiENSMUSG00000038670 Expressed in 79 organ(s), highest expression level in muscle of leg
CleanExiMM_MYBPC2
ExpressionAtlasiQ5XKE0 baseline and differential
GenevisibleiQ5XKE0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231385, 2 interactors
STRINGi10090.ENSMUSP00000130127

Structurei

Secondary structure

11136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5XKE0
SMRiQ5XKE0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5XKE0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 149Ig-like C2-type 1Add BLAST104
Domaini250 – 339Ig-like C2-type 2Add BLAST90
Domaini340 – 432Ig-like C2-type 3Add BLAST93
Domaini433 – 533Ig-like C2-type 4Add BLAST101
Domaini534 – 633Ig-like C2-type 5Add BLAST100
Domaini636 – 732Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini734 – 829Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini833 – 927Ig-like C2-type 6Add BLAST95
Domaini930 – 1025Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini1043 – 1136Ig-like C2-type 7Add BLAST94

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IFCI Eukaryota
ENOG4110AYI LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000220906
HOVERGENiHBG052560
InParanoidiQ5XKE0
KOiK12558
OMAiKVEYVPK
OrthoDBiEOG091G00ND
PhylomeDBiQ5XKE0
TreeFamiTF351819

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 7 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5XKE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEAKPAAKK ASKGKDAPKE APAKQTPEEP PKEAPPEDQS PTAEEPTGIF
60 70 80 90 100
LKKPDSVSVE TGKDAVILAK VNGKELPGKP TIKWFKGKWQ ELGSKSGARF
110 120 130 140 150
IFKESHDSTS NVYTVELHIG KVVLGDRGDY RLEIKAKDVC DSCSFNVDVE
160 170 180 190 200
APRQDSSGQS LESFKRSGDG KSEDAGELDF SGLLKKREVV EEEKKKKKDD
210 220 230 240 250
DDLGIPPEIW ELLKGAKKSE YEKIAFQYGI TDLRGMLKRL KKAKVEVKKS
260 270 280 290 300
AAFTKKLDPA YQVDRGNKIK LVVEISDPDL PLKWFKNGQE IKPSSKYVFE
310 320 330 340 350
NVGKKRILTI NKCTLADDAA YEVAVQDEKC FTELFVKEPP VLIVTPLEDQ
360 370 380 390 400
QVFVGDRVEM SVEVSEEGAQ VMWMKDGVEM TREDSYKARY RFKKDGKRHI
410 420 430 440 450
LIYSDVAQED GGRYQVITNG GQCEAELIVE EKQLEVLQDI ADLTVKAAEQ
460 470 480 490 500
AVFKCEVSDE KVTGKWYKNG VEVRPSKRIT ISHVGRFHKL VIDDVRPEDE
510 520 530 540 550
GDYTFVPDGY ALSLSAKLNF LEIKVEYVPK QEPPKIHLDC SGKTSDNSIV
560 570 580 590 600
VVAGNKLRLD VAITGEPPPT ATWLRGDEVF TATEGRTHIE QRPDCSSFVI
610 620 630 640 650
ESAERSDEGR YTIKVTNPVG EDVASIFLRV VDVPDPPEAV RVTSVGEDWA
660 670 680 690 700
ILVWEPPKYD GGQPVTGYLM ERKKKGSQRW MKINFEVFTD TTYESTKMIE
710 720 730 740 750
GVLYEMRVFA VNAIGVSQPS MNTKPFMPIA PTSAPQHLTV EDVTDTTTTL
760 770 780 790 800
KWRPPDRIGA GGIDGYLVEY CLEGSEEWVP ANKEPVERCG FTVKDLPTGA
810 820 830 840 850
RILFRVVGVN IAGRSEPATL LQPVTIREIV EQPKIRLPRH LRQTYIRKVG
860 870 880 890 900
EALNLVIPFQ GKPRPQVVWT KGGAPLDTSR VNVRTSDFDT VFFVRQAARS
910 920 930 940 950
DSGEYELSVQ IENMKDTATI RIRVVEKAGP AENVMVKEVW GTNALVEWQP
960 970 980 990 1000
PKDDGNSEIT GYFVQKADKK TMEWFNVYEH NRHTSCTVSD LIVGNEYYFR
1010 1020 1030 1040 1050
IFSENICGLS DSPGVSKNTA RILKTGITLK PLEYKEHDFR TAPKFLTPLM
1060 1070 1080 1090 1100
DRVVVAGYTA ALNCAVRGHP KPKVVWMKNK MEIHEDPKFL ITNYQGILTL
1110 1120 1130
NIRRPSPFDA GTYSCRAFNE LGEALAECKL DVRVPQ
Length:1,136
Mass (Da):127,352
Last modified:November 23, 2004 - v1
Checksum:iD79F73721397DE0D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LI70A0A140LI70_MOUSE
Myosin-binding protein C, fast-type
Mybpc2
155Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti619V → A in AAH29762 (PubMed:15489334).Curated1
Sequence conflicti648D → N in BAC26371 (PubMed:16141072).Curated1
Sequence conflicti900S → T in BAC26371 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029282 mRNA Translation: BAC26371.1
BC029762 mRNA Translation: AAH29762.1
BC039184 mRNA Translation: AAH39184.1
CCDSiCCDS52233.1
RefSeqiNP_666301.2, NM_146189.3
UniGeneiMm.358888

Genome annotation databases

EnsembliENSMUST00000165208; ENSMUSP00000130127; ENSMUSG00000038670
GeneIDi233199
KEGGimmu:233199
UCSCiuc009gpv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029282 mRNA Translation: BAC26371.1
BC029762 mRNA Translation: AAH29762.1
BC039184 mRNA Translation: AAH39184.1
CCDSiCCDS52233.1
RefSeqiNP_666301.2, NM_146189.3
UniGeneiMm.358888

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X5YNMR-A731-828[»]
2DLTNMR-A433-525[»]
ProteinModelPortaliQ5XKE0
SMRiQ5XKE0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231385, 2 interactors
STRINGi10090.ENSMUSP00000130127

PTM databases

CarbonylDBiQ5XKE0
iPTMnetiQ5XKE0
PhosphoSitePlusiQ5XKE0

Proteomic databases

MaxQBiQ5XKE0
PaxDbiQ5XKE0
PeptideAtlasiQ5XKE0
PRIDEiQ5XKE0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165208; ENSMUSP00000130127; ENSMUSG00000038670
GeneIDi233199
KEGGimmu:233199
UCSCiuc009gpv.2 mouse

Organism-specific databases

CTDi4606
MGIiMGI:1336170 Mybpc2

Phylogenomic databases

eggNOGiENOG410IFCI Eukaryota
ENOG4110AYI LUCA
GeneTreeiENSGT00860000133685
HOGENOMiHOG000220906
HOVERGENiHBG052560
InParanoidiQ5XKE0
KOiK12558
OMAiKVEYVPK
OrthoDBiEOG091G00ND
PhylomeDBiQ5XKE0
TreeFamiTF351819

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

EvolutionaryTraceiQ5XKE0
PROiPR:Q5XKE0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038670 Expressed in 79 organ(s), highest expression level in muscle of leg
CleanExiMM_MYBPC2
ExpressionAtlasiQ5XKE0 baseline and differential
GenevisibleiQ5XKE0 MM

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 7 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYPC2_MOUSE
AccessioniPrimary (citable) accession number: Q5XKE0
Secondary accession number(s): Q8C109, Q8K2V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 23, 2004
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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