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Entry version 117 (02 Jun 2021)
Sequence version 1 (23 Nov 2004)
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Protein
Submitted name:

Telomerase associated protein 1

Gene

Tep1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoproteinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Telomerase associated protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tep1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109573, Tep1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5XKB2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5XKB2, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini227 – 685TROVEInterPro annotationAdd BLAST459
Domaini1171 – 1578NACHTInterPro annotationAdd BLAST408
Domaini1679 – 2324WD_REPEATS_REGIONInterPro annotationAdd BLAST646
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1762 – 1803WDPROSITE-ProRule annotationAdd BLAST42
Repeati1845 – 1886WDPROSITE-ProRule annotationAdd BLAST42
Repeati2065 – 2099WDPROSITE-ProRule annotationAdd BLAST35
Repeati2111 – 2151WDPROSITE-ProRule annotationAdd BLAST41
Repeati2152 – 2182WDPROSITE-ProRule annotationAdd BLAST31
Repeati2242 – 2274WDPROSITE-ProRule annotationAdd BLAST33
Repeati2290 – 2315WDPROSITE-ProRule annotationAdd BLAST26
Domaini2553 – 2592WD_REPEATS_REGIONInterPro annotationAdd BLAST40
Repeati2553 – 2583WDPROSITE-ProRule annotationAdd BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni386 – 412DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi398 – 412Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLPRWVH

Database of Orthologous Groups

More...
OrthoDBi
29963at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025139, DUF4062
IPR007111, NACHT_NTPase
IPR027417, P-loop_NTPase
IPR011047, Quinoprotein_ADH-like_supfam
IPR008850, TEP1_N
IPR008858, TROVE_dom
IPR037214, TROVE_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13271, DUF4062, 1 hit
PF05729, NACHT, 1 hit
PF05386, TEP1_N, 4 hits
PF05731, TROVE, 1 hit
PF00400, WD40, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140864, SSF140864, 1 hit
SSF50978, SSF50978, 1 hit
SSF50998, SSF50998, 2 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50837, NACHT, 1 hit
PS51226, TEP1_N, 4 hits
PS50988, TROVE, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 8 hits
PS50294, WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5XKB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKLCGHVPG HSDILSLKNR CLTMLPDLQP LEKIHGHRSV HSDILSLENQ
60 70 80 90 100
CLTMLSDLQP TERIDGHISV HPDILSLENR CLTMLPDLQP LEKLCGHMSS
110 120 130 140 150
HPDVLSLENQ CLATLPTVKS TALTSPLLQG LHISHTAQAD LHSLKTSNCL
160 170 180 190 200
LPELPTKKTP CFSEELDLPP GPRALKSMSA TAQVQEVALG QWCVSKEKEF
210 220 230 240 250
QEEESTEVPM PLYSLSLEEE EVEAPVLKLT SGDSGFHPET TDQVLQEKKM
260 270 280 290 300
ALLTLLCSAL ASNVNVKDAS DLTRASILEV CSALASLEPE FILKASLYAR
310 320 330 340 350
QQLNLRDIAN TVLAVAALLP ACRPHVRRYY SAIVHLPSDW IQVAEFYQSL
360 370 380 390 400
AEGDEKKLVS LPACLRAAMT DKFAEFDEYQ LAKYNPRKHR SKRRSRQPPR
410 420 430 440 450
PQKTERPFSE RGKCFPKSLW PLKNEQITFE AAYNAMPEKN RLPRFTLKKL
460 470 480 490 500
VEYLHIHKPA QHVQALLGYR YPATLELFSR SHLPGPWESS RAGQRMKLRR
510 520 530 540 550
PETWERELSL RGNKASVWEE LIDNGKLPFM AMLRNLCNLL RTGISARHHE
560 570 580 590 600
LVLQRLQHEK SVVHSRQFPF RFLNAHDSID KLEAQLRSKA SPFPSNTTLM
610 620 630 640 650
KRIMIRNSKK NRRPASRKHL CTLTRRQLRA AMTIPVMYEQ LKREKLRLHK
660 670 680 690 700
ARQWNCDVEL LERYRQALET AVNLSVKHNL SPMPGRTLLV YLTDANADRL
710 720 730 740 750
CPKSHSQGPP LNYVLLLIGM MVARAEQVTV CLCGGGFVKT PVLTADEGIL
760 770 780 790 800
KTAIKLQAQV QELEGNDEWP LDTFGKYLLS LAVQRTPIDR VILFGQRMDT
810 820 830 840 850
ELLKVAKQII WQHVNSKCLF VGVLLQKTQY ISPNLNPNDV TLSGCTDGIL
860 870 880 890 900
KFIAEHGASR LLEHVGQLDK LFKIPPPPGK TQAPSLRPLE ENIPGPLGPI
910 920 930 940 950
SQHGWRNIRL FISSTFRDMH GERDLLMRSV LPALQARVFP HRISLHAIDL
960 970 980 990 1000
RWGITEEETR RNRQLEVCLG EVENSQLFVG ILGSRYGYIP PSYDLPDHPH
1010 1020 1030 1040 1050
FHWTHEYPSG RSVTEMEVMQ FLNRGQRSQP SAQALIYFRD PDFLSSVPDA
1060 1070 1080 1090 1100
WKPDFISESE EAAHRVSELK RYLHEQKEVT CRSYSCEWGG VAAGRPYTGG
1110 1120 1130 1140 1150
LEEFGQLVLQ DVWSMIQKQH LQPGAQLEQP TSISEDDLIQ TSFQQLKAPT
1160 1170 1180 1190 1200
SPARPRLLQD TVQQLLLPHG RLGLVTGQAG QGKTAFLASL VSALKVPDQP
1210 1220 1230 1240 1250
NEPPFVFFHF AAARPDQCLA LNLLRRLCTH LRQKLGELSA LPSTYRGLVW
1260 1270 1280 1290 1300
ELQQKLLLKF AQSLQPAQTL VLIIDGADKL VDRNGQLISD WIPKSLPRRV
1310 1320 1330 1340 1350
HLVLSVSSDS GLGETLQQSQ GAYVVALGSL VPSSRAQLVR EELALYGKRL
1360 1370 1380 1390 1400
EESPFNNQMR LLLAKQGSSL PLYLHLVTDY LRLFTLYEQV SERLRTLPAT
1410 1420 1430 1440 1450
LPLLLQHILS TLEQEHGHDV LPQALTALEV TRSGLTVDQL HAILSTWLIL
1460 1470 1480 1490 1500
PKETKSWEEV LAASHSGNPF PLCPFAYLVQ SLRSLLGEGP VERPGARLCL
1510 1520 1530 1540 1550
SDGPLRTTIK RRYGKRLGLE KTAHVLIAAH LWKTCDPDAS GTFRSCPPEA
1560 1570 1580 1590 1600
LKDLPYHLLQ SGNHGLLAEF LTNLHVVAAY LEVGLVPDLL EAHVLYASSK
1610 1620 1630 1640 1650
PEANQKLPAA DVAVFHTFLR QQASLLTQYP LLLLQQAASQ PEESPVCCQA
1660 1670 1680 1690 1700
PLLTQRWHDQ FTLKWINKPQ TLKGQQSLSL TMSSSPTAVA FSPNGQRAAV
1710 1720 1730 1740 1750
GTASGTIYLL NLKTWQEEKA VVSGCDGISS FAFLSDTALF LTTFDGHLEL
1760 1770 1780 1790 1800
WDLQHGCWVF QTKAHQYQIT GCCLSPDRRL LATVCLGGYL KLWDTVRGQL
1810 1820 1830 1840 1850
AFQYTHPKSL NCVAFHPEGQ VVATGSWAGS ITFFQADGLK VTKELGAPGP
1860 1870 1880 1890 1900
SVCSLAFNKP GKIVAVGRID GTVELWAWQE GARLVAFPAQ CGCVSAVLFL
1910 1920 1930 1940 1950
HAGDRFLTAG EDGKAQLWSG FLGRPRGCLG SLPLSPALSV ALNPDGDQVA
1960 1970 1980 1990 2000
VGYREDGINI YKISSGSQGP QHQELNVAVS ALVWLSPSVL VSGAEDGSLH
2010 2020 2030 2040 2050
GWMFKGDSLH SLWLLSRYQK PVLGLAASRE LMAAASEDFT VRLWPRQLLT
2060 2070 2080 2090 2100
QPHVHAVELP CCAELRGHEG PVCCCSFSPD GGILATAGRD RNLLCWDMKI
2110 2120 2130 2140 2150
AQAPLLIHTF SSCHRDWITG CAWTKDNILV SCSSDGSVGL WNPEAGQQLG
2160 2170 2180 2190 2200
QFSGHQSAVS AVVAVEEHIV SVSRDGTLKV WDHQGVELTS IPAHSGPISQ
2210 2220 2230 2240 2250
CAAALEPRPG GQPGSELLVV TVGLDGATKL WHPLLVCQIR TLQGHSGPVT
2260 2270 2280 2290 2300
AAAASEASGL LLTSDDSSVQ LWQIPKEADD SYKPRSSVAI TAVAWAPDGS
2310 2320 2330 2340 2350
MVVSGNEAGE LTLWQQAKAV ATAQAPGRVS HLIWYSANSF FVLSANENVS
2360 2370 2380 2390 2400
EWQVGLRKGS TSTSSSLHPK RVLQEDWGVL TGLGLAPDGQ SLILMKEDVE
2410 2420 2430 2440 2450
LLEMKPGSIP SSICRRYGVH SSILCTSKEY GLFYLQQGDS GLLSILEQKE
2460 2470 2480 2490 2500
SGEFEEILDF NLNLNNPNGS PVSITQAKPE SESSLLCATS DGMLWNLSEC
2510 2520 2530 2540 2550
TSEGEWIVDN IWQKKAKKPK TQTLETELSP HSELDFSIDC WIDPTNLKAQ
2560 2570 2580 2590 2600
QCKKIHLGSV TALHVLPGLL VTASKDRDVK LWERPSMQLL GLFRCEGPVS
2610 2620
CLEPWMEPSS PLQLAVGDTQ GNLYFLSWE
Length:2,629
Mass (Da):291,412
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3DB4E458657449E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC082996 mRNA Translation: AAH82996.1

NCBI Reference Sequences

More...
RefSeqi
NP_033377.1, NM_009351.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
21745

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:21745

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC082996 mRNA Translation: AAH82996.1
RefSeqiNP_033377.1, NM_009351.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiQ5XKB2

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
21745

Genome annotation databases

GeneIDi21745
KEGGimmu:21745

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7011
MGIiMGI:109573, Tep1

Phylogenomic databases

OMAiTLPRWVH
OrthoDBi29963at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
21745, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tep1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ5XKB2, MM

Family and domain databases

Gene3Di2.130.10.10, 5 hits
InterProiView protein in InterPro
IPR025139, DUF4062
IPR007111, NACHT_NTPase
IPR027417, P-loop_NTPase
IPR011047, Quinoprotein_ADH-like_supfam
IPR008850, TEP1_N
IPR008858, TROVE_dom
IPR037214, TROVE_dom_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF13271, DUF4062, 1 hit
PF05729, NACHT, 1 hit
PF05386, TEP1_N, 4 hits
PF05731, TROVE, 1 hit
PF00400, WD40, 5 hits
SMARTiView protein in SMART
SM00320, WD40, 16 hits
SUPFAMiSSF140864, SSF140864, 1 hit
SSF50978, SSF50978, 1 hit
SSF50998, SSF50998, 2 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50837, NACHT, 1 hit
PS51226, TEP1_N, 4 hits
PS50988, TROVE, 1 hit
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 8 hits
PS50294, WD_REPEATS_REGION, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5XKB2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5XKB2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: June 2, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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