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Protein

Coatomer subunit delta

Gene

Arcn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • cerebellar Purkinje cell layer maturation Source: MGI
  • Golgi vesicle transport Source: MGI
  • pigmentation Source: MGI
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: InterPro

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit delta
Alternative name(s):
Archain
Delta-coat protein
Short name:
Delta-COP
Gene namesi
Name:Arcn1
Synonyms:Copd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2387591 Arcn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938421 – 511Coatomer subunit deltaAdd BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223PhosphoserineBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei241N6-acetyllysineCombined sources1
Modified residuei244PhosphoserineBy similarity1
Modified residuei309N6-acetyllysineBy similarity1
Modified residuei351N6-acetyllysineCombined sources1
Modified residuei493PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5XJY5
MaxQBiQ5XJY5
PaxDbiQ5XJY5
PeptideAtlasiQ5XJY5
PRIDEiQ5XJY5

2D gel databases

REPRODUCTION-2DPAGEiQ5XJY5

PTM databases

iPTMnetiQ5XJY5
PhosphoSitePlusiQ5XJY5
SwissPalmiQ5XJY5

Expressioni

Gene expression databases

BgeeiENSMUSG00000032096
CleanExiMM_ARCN1
GenevisibleiQ5XJY5 MM

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.By similarity

Protein-protein interaction databases

BioGridi229475, 4 interactors
CORUMiQ5XJY5
IntActiQ5XJY5, 3 interactors
MINTiQ5XJY5
STRINGi10090.ENSMUSP00000034607

Structurei

3D structure databases

ProteinModelPortaliQ5XJY5
SMRiQ5XJY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini271 – 511MHDPROSITE-ProRule annotationAdd BLAST241

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2635 Eukaryota
ENOG410XRH2 LUCA
GeneTreeiENSGT00390000017207
HOGENOMiHOG000203984
HOVERGENiHBG005381
InParanoidiQ5XJY5
KOiK20471
OMAiCWPSENG
OrthoDBiEOG091G08B5
TreeFamiTF105760

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR027059 Coatomer_dsu
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PANTHERiPTHR10121 PTHR10121, 1 hit
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS51072 MHD, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XJY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE
60 70 80 90 100
TESVRYVYQP MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN
110 120 130 140 150
EISEHCFDLI FAFDEIVALG YRENVNLAQI RTFTEMDSHE EKVFRAVRET
160 170 180 190 200
QEREAKAEMR RKAKELQQAR RDAERQGKKA PGFGGFGSSA VSGGSTAAMI
210 220 230 240 250
TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD KLKSEGETIM
260 270 280 290 300
SSNMGKRTSE ATKVHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM
310 320 330 340 350
IMLRISDDKF GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE
360 370 380 390 400
KSFPVNSDVG VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED
410 420 430 440 450
NLELNDVVIT IPLPSGVGAP VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK
460 470 480 490 500
SGSLEFSIPG QPNDFFPVQV SFISKKNYCN IQVTKVTQVD GNSPVRFSTE
510
TTFLVDKYEI L
Length:511
Mass (Da):57,229
Last modified:June 28, 2011 - v2
Checksum:i4C20F48A75330DC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301I → T in AAH83152 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028556 mRNA Translation: BAC26007.1
CH466522 Genomic DNA Translation: EDL25614.1
BC017124 mRNA Translation: AAH17124.1
BC023728 mRNA Translation: AAH23728.1
BC033387 mRNA Translation: AAH33387.1
BC034754 mRNA Translation: AAH34754.1
BC083152 mRNA Translation: AAH83152.1
CCDSiCCDS40602.1
RefSeqiNP_666097.3, NM_145985.4
UniGeneiMm.371682

Genome annotation databases

EnsembliENSMUST00000034607; ENSMUSP00000034607; ENSMUSG00000032096
GeneIDi213827
KEGGimmu:213827
UCSCiuc009pei.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCOPD_MOUSE
AccessioniPrimary (citable) accession number: Q5XJY5
Secondary accession number(s): Q91W48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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