SET domain-containing protein 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• covalent chromatin modification Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 27864380
• regulation of chromatin organization Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27864380
• regulation of histone acetylation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27864380

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSIAIPLGVT TPDTSYSDMA AGSDPESVEA SPAVNEKSVY STHNYGTTQR 
        60         70         80         90        100
HGCRGLPYAT IIPRSDLNGL PSPVEERCGD SPNSEGETVP TWCPCGLSQD 
       110        120        130        140        150
GFLLNCDKCR GMSRGKVIRL HRRKQDNISG GDSSATESWD EELSPSTVLY 
       160        170        180        190        200
TATQHTPTSI TLTVRRTKPK KRKKSPEKGR AAPKTKKIKN SPSEAQNLDE 
       210        220        230        240        250
NTTEGWENRI RLWTDQYEEA FTNQYSADVQ NALEQHLHSN KEFVGKPAIL 
       260        270        280        290        300
DTINKTELAC NNTVIGSQMQ LQLGRVTRVQ KHRKILRAAR DLALDTLIIE 
       310        320        330        340        350
YRGKVMLRQQ FEVNGHFFKK PYPFVLFYSK FNGVEMCVDA RTFGNDARFI 
       360        370        380        390        400
RRSCTPNAEV RHMIADGMIH LCIYAVSAIT KDAEVTIAFD YEYSNCNYKV 
       410        420        430        440        450
DCACHKGNRN CPIQKRNPNA AELPLPPPPS FPTIGAETRR RKARRKELEL 
       460        470        480        490        500
EQQNEVPEEN PDPQPQEVPE KVTVSNEHEE VDNPEEKPEE EEKEEATDDQ 
       510        520        530        540        550
ENSAHSRRTR EDRKVEAIMH AFESLEKRKK RRDQPVEQSS SDIEITTSSS 
       560        570        580        590        600
EIVVGEETKT AAPESEVSSP VSNVAIPSTP QSTGVNTRRS SHAGDVAAEK 
       610        620        630        640        650
PIPKPPPAKP SRPRPKSRIS RYRTSSAQRL KRQKQAIAQQ AELSQAALEE 
       660        670        680        690        700
GGSNNSVTPP EAGNTDSSGE NRQLTGSDPT VISVTGSHVN RAASKYPKTK 
       710        720        730        740        750
KYLVTEWLND KAEKQECPVE CPLRITTDPT VLATTLNMLP GLIHSPLICT 
       760        770        780        790        800
TPKHYIRFGS PFMPERRRRP LLPDGTFSSC KKRWIKQALE EGMTQTSSVP 
       810        820        830        840        850
QETRTQHLYQ SNETSNSSSI CKDNADLLSP LKKWKSRYLM EQNITKLLQP 
       860        870        880        890        900
LSPVTPPPPS SGSKSPQLTT PGQTHPGEEE CRNGYSLMFS PITSLTTASR 
       910        920        930        940        950
SNTPLQFELC HRKDLDLTKV GFPDSSTHSC ADRPSLLNCN HPDLASHPSV 
       960        970        980        990       1000
VPTSEAGFPS RSGDGPQTLL RNSDQAFRTE FNLMYAYSPL NAMPRADGLY 
      1010       1020       1030       1040       1050
RGSPLVGDRK PLHLDGGYCS PAEGFSSRYE HGFMKDLSRG SMSPGGERTC 
      1060       1070       1080       1090       1100
EGVPSAPQNP PQRKKVSLLE YRKRKQEAKE NSGGGNDSSQ SKSKSSGAGQ 
      1110       1120       1130       1140       1150
GSSNSVSDTG AHGVQGSSAG TPSSPHKKFS PSHSSASHLE AVSPSDSRGT 
      1160       1170       1180       1190       1200
SSSHCRPQEN ISSRWMVPTS VERLREGGSI PKVLRSSVRV AQKGEPSPTW 
      1210       1220       1230       1240       1250
ESNITEKESD PADGEGPEPL SSALSKGATV YSPSRYSYQL LQCDSPRTES 
      1260       1270       1280       1290       1300
QSLLQQSSSP FRGHPTQSPG YSYRTTALRP GNPPSHGSSE SSLSSTSYPS 
      1310       1320       1330       1340       1350
PAHPVSTDSL APFTGTPGYY SSQPHSGNST GSNLPRRSCS SSAASPTPQG 
      1360       1370       1380       1390       1400
PSDSPTSDSV SQSSTGTLSS TSFPQNSRSS LPSDLRTISL PNAGQSAAYQ 
      1410       1420       1430       1440 
ASRVSAVSNS QHYPHRGSGG VHQYRLQPLQ GSGVKTQTGL S          

        10         20         30         40         50
MSIAIPLGVT TPDTSYSDMA AGSDPESVEA SPAVNEKSVY STHNYGTTQR 
        60         70         80         90        100
HGCRGLPYAD HNYGAPPPPT PPASPPVQTI IPRSDLNGLP SPVEERCGDS 
       110        120        130        140        150
PNSEGETVPT WCPCGLSQDG FLLNCDKCRG MSRGKVIRLH RRKQDNISGG 
       160        170        180        190        200
DSSATESWDE ELSPSTVLYT ATQHTPTSIT LTVRRTKPKK RKKSPEKGRA 
       210        220        230        240        250
APKTKKIKNS PSEAQNLDEN TTEGWENRIR LWTDQYEEAF TNQYSADVQN 
       260        270        280        290        300
ALEQHLHSNK EFVGKPAILD TINKTELACN NTVIGSQMQL QLGRVTRVQK 
       310        320        330        340        350
HRKILRAARD LALDTLIIEY RGKVMLRQQF EVNGHFFKKP YPFVLFYSKF 
       360        370        380        390        400
NGVEMCVDAR TFGNDARFIR RSCTPNAEVR HMIADGMIHL CIYAVSAITK 
       410        420        430        440        450
DAEVTIAFDY EYSNCNYKVD CACHKGNRNC PIQKRNPNAA ELPLPPPPSF 
       460        470        480        490        500
PTIGAETRRR KARRKELELE QQNEVPEENP DPQPQEVPEK VTVSNEHEEV 
       510        520        530        540        550
DNPEEKPEEE EKEEATDDQE NSAHSRRTRE DRKVEAIMHA FESLEKRKKR 
       560        570        580        590        600
RDQPVEQSSS DIEITTSSSE IVVGEETKTA APESEVSSPV SNVAIPSTPQ 
       610        620        630        640        650
STGVNTRRSS HAGDVAAEKP IPKPPPAKPS RPRPKSRISR YRTSSAQRLK 
       660        670        680        690        700
RQKQAIAQQA ELSQAALEEG GSNNSVTPPE AGNTDSSGEN RQLTGSDPTV 
       710        720        730        740        750
ISVTGSHVNR AASKYPKTKK YLVTEWLNDK AEKQECPVEC PLRITTDPTV 
       760        770        780        790        800
LATTLNMLPG LIHSPLICTT PKHYIRFGSP FMPERRRRPL LPDGTFSSCK 
       810        820        830        840        850
KRWIKQALEE GMTQTSSVPQ ETRTQHLYQS NETSNSSSIC KDNADLLSPL 
       860        870        880        890        900
KKWKSRYLME QNITKLLQPL SPVTPPPPSS GSKSPQLTTP GQTHPGEEEC 
       910        920        930        940        950
RNGYSLMFSP ITSLTTASRS NTPLQFELCH RKDLDLTKVG FPDSSTHSCA 
       960        970        980        990       1000
DRPSLLNCNH PDLASHPSVV PTSEAGFPSR SGDGPQTLLR NSDQAFRTEF 
      1010       1020       1030       1040       1050
NLMYAYSPLN AMPRADGLYR GSPLVGDRKP LHLDGGYCSP AEGFSSRYEH 
      1060       1070       1080       1090       1100
GFMKDLSRGS MSPGGERTCE GVPSAPQNPP QRKKVSLLEY RKRKQEAKEN 
      1110       1120       1130       1140       1150
SGGGNDSSQS KSKSSGAGQG SSNSVSDTGA HGVQGSSAGT PSSPHKKFSP 
      1160       1170       1180       1190       1200
SHSSASHLEA VSPSDSRGTS SSHCRPQENI SSRWMVPTSV ERLREGGSIP 
      1210       1220       1230       1240       1250
KVLRSSVRVA QKGEPSPTWE SNITEKESDP ADGEGPEPLS SALSKGATVY 
      1260       1270       1280       1290       1300
SPSRYSYQLL QCDSPRTESQ SLLQQSSSPF RGHPTQSPGY SYRTTALRPG 
      1310       1320       1330       1340       1350
NPPSHGSSES SLSSTSYPSP AHPVSTDSLA PFTGTPGYYS SQPHSGNSTG 
      1360       1370       1380       1390       1400
SNLPRRSCSS SAASPTPQGP SDSPTSDSVS QSSTGTLSST SFPQNSRSSL 
      1410       1420       1430       1440       1450
PSDLRTISLP NAGQSAAYQA SRVSAVSNSQ HYPHRGSGGV HQYRLQPLQG 
      1460
SGVKTQTGLS                                             

        10         20         30         40         50
MTQTSSVPQE TRTQHLYQSN ETSNSSSICK DNADLLSPLK KWKSRYLMEQ 
        60         70         80         90        100
NITKLLQPLS PVTPPPPSSG SKSPQLTTPG QTHPGEEECR NGYSLMFSPI 
       110        120        130        140        150
TSLTTASRSN TPLQFELCHR KDLDLTKVGF PDSSTHSCAD RPSLLNCNHP 
       160        170        180        190        200
DLASHPSVVP TSEAGFPSRS GDGPQTLLRN SDQAFRTEFN LMYAYSPLNA 
       210        220        230        240        250
MPRADGLYRG SPLVGDRKPL HLDGGYCSPA EGFSSRYEHG FMKDLSRGSM 
       260        270        280        290        300
SPGGERTCEG VPSAPQNPPQ RKKVSLLEYR KRKQEAKENS GGGNDSSQSK 
       310        320        330        340        350
SKSSGAGQGS SNSVSDTGAH GVQGSSAGTP SSPHKKFSPS HSSASHLEAV 
       360        370        380        390        400
SPSDSRGTSS SHCRPQENIS SRWMVPTSVE RLREGGSIPK VLRSSVRVAQ 
       410        420        430        440        450
KGEPSPTWES NITEKESDPA DGEGPEPLSS ALSKGATVYS PSRYSYQLLQ 
       460        470        480        490        500
CDSPRTESQS LLQQSSSPFR GHPTQSPGYS YRTTALRPGN PPSHGSSESS 
       510        520        530        540        550
LSSTSYPSPA HPVSTDSLAP FTGTPGYYSS QPHSGNSTGS NLPRRSCSSS 
       560        570        580        590        600
AASPTPQGPS DSPTSDSVSQ SSTGTLSSTS FPQNSRSSLP SDLRTISLPN 
       610        620        630        640 
AGQSAAYQAS RVSAVSNSQH YPHRGSGGVH QYRLQPLQGS GVKTQTGLS  

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot