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Protein

SET domain-containing protein 5

Gene

Setd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Acts as a regulator of histone acetylation during gene transcription.1 Publication

GO - Biological processi

  • covalent chromatin modification Source: UniProtKB
  • regulation of chromatin organization Source: UniProtKB
  • regulation of histone acetylation Source: UniProtKB

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SET domain-containing protein 5Curated
Gene namesi
Name:Setd51 PublicationImported
Synonyms:Kiaa17571 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1920145 Setd5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mid-gestation lethality due to severe developmental delay such as vascular abnormalities in the embryo and placenta, reduced cellular proliferation and increased apoptosis (PubMed:27864380). Defects are probably due to a widespread impairment in the regulation of gene expression (PubMed:27864380).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002819061 – 1441SET domain-containing protein 5Add BLAST1441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineCombined sources1
Modified residuei829PhosphoserineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphothreonineCombined sources1
Modified residuei1197PhosphoserineBy similarity1
Isoform 2 (identifier: Q5XJV7-2)
Modified residuei70PhosphothreonineCombined sources1
Modified residuei74PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5XJV7
PaxDbiQ5XJV7
PeptideAtlasiQ5XJV7
PRIDEiQ5XJV7

PTM databases

iPTMnetiQ5XJV7
PhosphoSitePlusiQ5XJV7

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000034269 Expressed in 265 organ(s), highest expression level in ascending aorta
CleanExiMM_SETD5
GenevisibleiQ5XJV7 MM

Interactioni

Subunit structurei

Interacts with components of the PAF1 complex (PAF1C) such as LEO1, CTR9 and CDC73 (PubMed:27864380). Interacts with NCOR1 (PubMed:27864380).1 Publication

Protein-protein interaction databases

BioGridi215631, 6 interactors
IntActiQ5XJV7, 6 interactors
STRINGi10090.ENSMUSP00000047398

Structurei

3D structure databases

ProteinModelPortaliQ5XJV7
SMRiQ5XJV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 390SETPROSITE-ProRule annotationAdd BLAST122

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1088 – 1410Ser-richAdd BLAST323

Phylogenomic databases

eggNOGiENOG410IMXD Eukaryota
ENOG410ZTNX LUCA
GeneTreeiENSGT00520000055602
HOGENOMiHOG000154294
HOVERGENiHBG068103
InParanoidiQ5XJV7
OMAiPEEECRN
OrthoDBiEOG091G00UT
PhylomeDBiQ5XJV7
TreeFamiTF106417

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5XJV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSIAIPLGVT TPDTSYSDMA AGSDPESVEA SPAVNEKSVY STHNYGTTQR
60 70 80 90 100
HGCRGLPYAT IIPRSDLNGL PSPVEERCGD SPNSEGETVP TWCPCGLSQD
110 120 130 140 150
GFLLNCDKCR GMSRGKVIRL HRRKQDNISG GDSSATESWD EELSPSTVLY
160 170 180 190 200
TATQHTPTSI TLTVRRTKPK KRKKSPEKGR AAPKTKKIKN SPSEAQNLDE
210 220 230 240 250
NTTEGWENRI RLWTDQYEEA FTNQYSADVQ NALEQHLHSN KEFVGKPAIL
260 270 280 290 300
DTINKTELAC NNTVIGSQMQ LQLGRVTRVQ KHRKILRAAR DLALDTLIIE
310 320 330 340 350
YRGKVMLRQQ FEVNGHFFKK PYPFVLFYSK FNGVEMCVDA RTFGNDARFI
360 370 380 390 400
RRSCTPNAEV RHMIADGMIH LCIYAVSAIT KDAEVTIAFD YEYSNCNYKV
410 420 430 440 450
DCACHKGNRN CPIQKRNPNA AELPLPPPPS FPTIGAETRR RKARRKELEL
460 470 480 490 500
EQQNEVPEEN PDPQPQEVPE KVTVSNEHEE VDNPEEKPEE EEKEEATDDQ
510 520 530 540 550
ENSAHSRRTR EDRKVEAIMH AFESLEKRKK RRDQPVEQSS SDIEITTSSS
560 570 580 590 600
EIVVGEETKT AAPESEVSSP VSNVAIPSTP QSTGVNTRRS SHAGDVAAEK
610 620 630 640 650
PIPKPPPAKP SRPRPKSRIS RYRTSSAQRL KRQKQAIAQQ AELSQAALEE
660 670 680 690 700
GGSNNSVTPP EAGNTDSSGE NRQLTGSDPT VISVTGSHVN RAASKYPKTK
710 720 730 740 750
KYLVTEWLND KAEKQECPVE CPLRITTDPT VLATTLNMLP GLIHSPLICT
760 770 780 790 800
TPKHYIRFGS PFMPERRRRP LLPDGTFSSC KKRWIKQALE EGMTQTSSVP
810 820 830 840 850
QETRTQHLYQ SNETSNSSSI CKDNADLLSP LKKWKSRYLM EQNITKLLQP
860 870 880 890 900
LSPVTPPPPS SGSKSPQLTT PGQTHPGEEE CRNGYSLMFS PITSLTTASR
910 920 930 940 950
SNTPLQFELC HRKDLDLTKV GFPDSSTHSC ADRPSLLNCN HPDLASHPSV
960 970 980 990 1000
VPTSEAGFPS RSGDGPQTLL RNSDQAFRTE FNLMYAYSPL NAMPRADGLY
1010 1020 1030 1040 1050
RGSPLVGDRK PLHLDGGYCS PAEGFSSRYE HGFMKDLSRG SMSPGGERTC
1060 1070 1080 1090 1100
EGVPSAPQNP PQRKKVSLLE YRKRKQEAKE NSGGGNDSSQ SKSKSSGAGQ
1110 1120 1130 1140 1150
GSSNSVSDTG AHGVQGSSAG TPSSPHKKFS PSHSSASHLE AVSPSDSRGT
1160 1170 1180 1190 1200
SSSHCRPQEN ISSRWMVPTS VERLREGGSI PKVLRSSVRV AQKGEPSPTW
1210 1220 1230 1240 1250
ESNITEKESD PADGEGPEPL SSALSKGATV YSPSRYSYQL LQCDSPRTES
1260 1270 1280 1290 1300
QSLLQQSSSP FRGHPTQSPG YSYRTTALRP GNPPSHGSSE SSLSSTSYPS
1310 1320 1330 1340 1350
PAHPVSTDSL APFTGTPGYY SSQPHSGNST GSNLPRRSCS SSAASPTPQG
1360 1370 1380 1390 1400
PSDSPTSDSV SQSSTGTLSS TSFPQNSRSS LPSDLRTISL PNAGQSAAYQ
1410 1420 1430 1440
ASRVSAVSNS QHYPHRGSGG VHQYRLQPLQ GSGVKTQTGL S
Length:1,441
Mass (Da):157,426
Last modified:April 3, 2007 - v2
Checksum:i67120734D6EB6DD9
GO
Isoform 2 (identifier: Q5XJV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-59: A → ADHNYGAPPPPTPPASPPVQ

Note: No experimental confirmation available.Combined sources
Show »
Length:1,460
Mass (Da):159,347
Checksum:i78661129B0FF47D3
GO
Isoform 3 (identifier: Q5XJV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-792: Missing.

Note: No experimental confirmation available.
Show »
Length:649
Mass (Da):68,981
Checksum:iCEFA3C76B4496610
GO

Sequence cautioni

The sequence BAC33569 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65833 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1381L → F in AAH83184 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0240961 – 792Missing in isoform 3. 1 PublicationAdd BLAST792
Alternative sequenceiVSP_02409759A → ADHNYGAPPPPTPPASPPVQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122551 mRNA Translation: BAC65833.1 Different initiation.
AK049143 mRNA Translation: BAC33569.1 Different initiation.
AK053541 mRNA Translation: BAC35420.1
BC083184 mRNA Translation: AAH83184.1
CCDSiCCDS20411.1 [Q5XJV7-1]
RefSeqiNP_082661.1, NM_028385.1 [Q5XJV7-1]
NP_766593.1, NM_173005.1 [Q5XJV7-2]
XP_011239784.1, XM_011241482.2 [Q5XJV7-2]
UniGeneiMm.367159

Genome annotation databases

EnsembliENSMUST00000042889; ENSMUSP00000047398; ENSMUSG00000034269 [Q5XJV7-1]
ENSMUST00000113155; ENSMUSP00000108780; ENSMUSG00000034269 [Q5XJV7-2]
ENSMUST00000113157; ENSMUSP00000108782; ENSMUSG00000034269 [Q5XJV7-2]
GeneIDi72895
KEGGimmu:72895
UCSCiuc009deq.1 mouse [Q5XJV7-1]
uc009der.1 mouse [Q5XJV7-2]
uc009deu.1 mouse [Q5XJV7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122551 mRNA Translation: BAC65833.1 Different initiation.
AK049143 mRNA Translation: BAC33569.1 Different initiation.
AK053541 mRNA Translation: BAC35420.1
BC083184 mRNA Translation: AAH83184.1
CCDSiCCDS20411.1 [Q5XJV7-1]
RefSeqiNP_082661.1, NM_028385.1 [Q5XJV7-1]
NP_766593.1, NM_173005.1 [Q5XJV7-2]
XP_011239784.1, XM_011241482.2 [Q5XJV7-2]
UniGeneiMm.367159

3D structure databases

ProteinModelPortaliQ5XJV7
SMRiQ5XJV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215631, 6 interactors
IntActiQ5XJV7, 6 interactors
STRINGi10090.ENSMUSP00000047398

PTM databases

iPTMnetiQ5XJV7
PhosphoSitePlusiQ5XJV7

Proteomic databases

EPDiQ5XJV7
PaxDbiQ5XJV7
PeptideAtlasiQ5XJV7
PRIDEiQ5XJV7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042889; ENSMUSP00000047398; ENSMUSG00000034269 [Q5XJV7-1]
ENSMUST00000113155; ENSMUSP00000108780; ENSMUSG00000034269 [Q5XJV7-2]
ENSMUST00000113157; ENSMUSP00000108782; ENSMUSG00000034269 [Q5XJV7-2]
GeneIDi72895
KEGGimmu:72895
UCSCiuc009deq.1 mouse [Q5XJV7-1]
uc009der.1 mouse [Q5XJV7-2]
uc009deu.1 mouse [Q5XJV7-3]

Organism-specific databases

CTDi55209
MGIiMGI:1920145 Setd5
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IMXD Eukaryota
ENOG410ZTNX LUCA
GeneTreeiENSGT00520000055602
HOGENOMiHOG000154294
HOVERGENiHBG068103
InParanoidiQ5XJV7
OMAiPEEECRN
OrthoDBiEOG091G00UT
PhylomeDBiQ5XJV7
TreeFamiTF106417

Miscellaneous databases

ChiTaRSiSetd5 mouse
PROiPR:Q5XJV7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034269 Expressed in 265 organ(s), highest expression level in ascending aorta
CleanExiMM_SETD5
GenevisibleiQ5XJV7 MM

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSETD5_MOUSE
AccessioniPrimary (citable) accession number: Q5XJV7
Secondary accession number(s): Q80T94, Q8BKD5, Q8BX30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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