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UniProtKB - Q5XJV7 (SETD5_MOUSE)

Entry version 118 (29 Sep 2021)
Sequence version 2 (03 Apr 2007)
Previous versions | rss
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Protein

Histone-lysine N-methyltransferase SETD5

Gene

Setd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission (PubMed:30455454, PubMed:31515109).

May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics (PubMed:31515109).

Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622).

The relevance of histone methyltransferase activity is however subject to discussion (PubMed:27864380, PubMed:30455454).

4 Publications

Caution

According to a report, lacks histone methyltransferase activity and regulates chromatin by interacting with HDAC3 and PAF1 complex (PAF1C) complex (PubMed:30455454). According to another publication, displays histone methyltransferase activity and directly trimethylates 'Lys-36' of histone H3 (H3K36me3) (PubMed:31515109).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD5Curated (EC:2.1.1.3591 Publication, EC:2.1.1.3671 Publication)
Alternative name(s):
SET domain-containing protein 5Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Setd51 PublicationImported
Synonyms:Kiaa17571 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1920145, Setd5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000034269

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mid-gestation lethality due to severe developmental delay such as vascular abnormalities in the embryo and placenta, reduced cellular proliferation and increased apoptosis (PubMed:27864380). Defects are probably due to a widespread impairment in the regulation of gene expression (PubMed:27864380). Setd5-haploinsufficient mice display altered neuronal network connectivity leading to autistic-like behaviors (PubMed:30655503, PubMed:30455454, PubMed:31515109). Haploinsufficient Setd5 cortical neurons show reduced synaptic density and neuritic outgrowtho, with corresponding decreases in network activity and synchrony by electrophysiology (PubMed:30655503). Haploinsufficient mice display several autism-like behaviors, including hyperactivity, cognitive deficit, and altered social interactions (PubMed:30455454, PubMed:31515109, PubMed:30655503).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002819061 – 1441Histone-lysine N-methyltransferase SETD5Add BLAST1441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei72PhosphoserineCombined sources1
Modified residuei829PhosphoserineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphothreonineCombined sources1
Modified residuei1197PhosphoserineBy similarity1
Isoform 2 (identifier: Q5XJV7-2)
Modified residuei70PhosphothreonineCombined sources1
Modified residuei74PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5XJV7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5XJV7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5XJV7

PeptideAtlas

More...PeptideAtlasi		Q5XJV7

PRoteomics IDEntifications database

More...PRIDEi		Q5XJV7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		261498 [Q5XJV7-1]
261499 [Q5XJV7-2]
261500 [Q5XJV7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5XJV7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5XJV7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000034269, Expressed in undifferentiated genital tubercle and 287 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5XJV7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with components of the PAF1 complex (PAF1C) such as LEO1, CTR9 and CDC73 (PubMed:27864380).

Interacts with NCOR1 (PubMed:27864380).

Interacts with HDAC3 (PubMed:30455454).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		215631, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q5XJV7, 6 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000047398

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5XJV7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini269 – 390SETPROSITE-ProRule annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni156 – 202DisorderedSequence analysisAdd BLAST47
Regioni417 – 683DisorderedSequence analysisAdd BLAST267
Regioni793 – 816DisorderedSequence analysisAdd BLAST24
Regioni849 – 883DisorderedSequence analysisAdd BLAST35
Regioni1036 – 1228DisorderedSequence analysisAdd BLAST193
Regioni1243 – 1441DisorderedSequence analysisAdd BLAST199

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 21Polar residuesSequence analysisAdd BLAST15
Compositional biasi165 – 180Basic residuesSequence analysisAdd BLAST16
Compositional biasi437 – 453Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi483 – 497Acidic residuesSequence analysisAdd BLAST15
Compositional biasi498 – 538Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi539 – 555Polar residuesSequence analysisAdd BLAST17
Compositional biasi562 – 590Polar residuesSequence analysisAdd BLAST29
Compositional biasi620 – 683Polar residuesSequence analysisAdd BLAST64
Compositional biasi1066 – 1081Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1082 – 1167Polar residuesSequence analysisAdd BLAST86
Compositional biasi1243 – 1416Polar residuesSequence analysisAdd BLAST174

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1844, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157446

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002373_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5XJV7

Identification of Orthologs from Complete Genome Data

More...OMAi		EPSPTWD

Database of Orthologous Groups

More...OrthoDBi		86638at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5XJV7

TreeFam database of animal gene trees

More...TreeFami		TF106417

Family and domain databases

Conserved Domains Database

More...CDDi		cd19181, SET_SETD5, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001214, SET_dom
IPR044433, SETD5_SET

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00317, SET, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5XJV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSIAIPLGVT TPDTSYSDMA AGSDPESVEA SPAVNEKSVY STHNYGTTQR 
        60         70         80         90        100
HGCRGLPYAT IIPRSDLNGL PSPVEERCGD SPNSEGETVP TWCPCGLSQD 
       110        120        130        140        150
GFLLNCDKCR GMSRGKVIRL HRRKQDNISG GDSSATESWD EELSPSTVLY 
       160        170        180        190        200
TATQHTPTSI TLTVRRTKPK KRKKSPEKGR AAPKTKKIKN SPSEAQNLDE 
       210        220        230        240        250
NTTEGWENRI RLWTDQYEEA FTNQYSADVQ NALEQHLHSN KEFVGKPAIL 
       260        270        280        290        300
DTINKTELAC NNTVIGSQMQ LQLGRVTRVQ KHRKILRAAR DLALDTLIIE 
       310        320        330        340        350
YRGKVMLRQQ FEVNGHFFKK PYPFVLFYSK FNGVEMCVDA RTFGNDARFI 
       360        370        380        390        400
RRSCTPNAEV RHMIADGMIH LCIYAVSAIT KDAEVTIAFD YEYSNCNYKV 
       410        420        430        440        450
DCACHKGNRN CPIQKRNPNA AELPLPPPPS FPTIGAETRR RKARRKELEL 
       460        470        480        490        500
EQQNEVPEEN PDPQPQEVPE KVTVSNEHEE VDNPEEKPEE EEKEEATDDQ 
       510        520        530        540        550
ENSAHSRRTR EDRKVEAIMH AFESLEKRKK RRDQPVEQSS SDIEITTSSS 
       560        570        580        590        600
EIVVGEETKT AAPESEVSSP VSNVAIPSTP QSTGVNTRRS SHAGDVAAEK 
       610        620        630        640        650
PIPKPPPAKP SRPRPKSRIS RYRTSSAQRL KRQKQAIAQQ AELSQAALEE 
       660        670        680        690        700
GGSNNSVTPP EAGNTDSSGE NRQLTGSDPT VISVTGSHVN RAASKYPKTK 
       710        720        730        740        750
KYLVTEWLND KAEKQECPVE CPLRITTDPT VLATTLNMLP GLIHSPLICT 
       760        770        780        790        800
TPKHYIRFGS PFMPERRRRP LLPDGTFSSC KKRWIKQALE EGMTQTSSVP 
       810        820        830        840        850
QETRTQHLYQ SNETSNSSSI CKDNADLLSP LKKWKSRYLM EQNITKLLQP 
       860        870        880        890        900
LSPVTPPPPS SGSKSPQLTT PGQTHPGEEE CRNGYSLMFS PITSLTTASR 
       910        920        930        940        950
SNTPLQFELC HRKDLDLTKV GFPDSSTHSC ADRPSLLNCN HPDLASHPSV 
       960        970        980        990       1000
VPTSEAGFPS RSGDGPQTLL RNSDQAFRTE FNLMYAYSPL NAMPRADGLY 
      1010       1020       1030       1040       1050
RGSPLVGDRK PLHLDGGYCS PAEGFSSRYE HGFMKDLSRG SMSPGGERTC 
      1060       1070       1080       1090       1100
EGVPSAPQNP PQRKKVSLLE YRKRKQEAKE NSGGGNDSSQ SKSKSSGAGQ 
      1110       1120       1130       1140       1150
GSSNSVSDTG AHGVQGSSAG TPSSPHKKFS PSHSSASHLE AVSPSDSRGT 
      1160       1170       1180       1190       1200
SSSHCRPQEN ISSRWMVPTS VERLREGGSI PKVLRSSVRV AQKGEPSPTW 
      1210       1220       1230       1240       1250
ESNITEKESD PADGEGPEPL SSALSKGATV YSPSRYSYQL LQCDSPRTES 
      1260       1270       1280       1290       1300
QSLLQQSSSP FRGHPTQSPG YSYRTTALRP GNPPSHGSSE SSLSSTSYPS 
      1310       1320       1330       1340       1350
PAHPVSTDSL APFTGTPGYY SSQPHSGNST GSNLPRRSCS SSAASPTPQG 
      1360       1370       1380       1390       1400
PSDSPTSDSV SQSSTGTLSS TSFPQNSRSS LPSDLRTISL PNAGQSAAYQ 
      1410       1420       1430       1440 
ASRVSAVSNS QHYPHRGSGG VHQYRLQPLQ GSGVKTQTGL S
Length:1,441
Mass (Da):157,426
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67120734D6EB6DD9
GO
Isoform 2 (identifier: Q5XJV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-59: A → ADHNYGAPPPPTPPASPPVQ

Show »
Length:1,460
Mass (Da):159,347
Checksum:i78661129B0FF47D3
GO
Isoform 3 (identifier: Q5XJV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-792: Missing.

Show »
Length:649
Mass (Da):68,981
Checksum:iCEFA3C76B4496610
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC33569 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65833 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1381L → F in AAH83184 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0240961 – 792Missing in isoform 3. 1 PublicationAdd BLAST792
Alternative sequenceiVSP_02409759A → ADHNYGAPPPPTPPASPPVQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK122551 mRNA Translation: BAC65833.1 Different initiation.
AK049143 mRNA Translation: BAC33569.1 Different initiation.
AK053541 mRNA Translation: BAC35420.1
BC083184 mRNA Translation: AAH83184.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS20411.1 [Q5XJV7-1]
CCDS90096.1 [Q5XJV7-2]

NCBI Reference Sequences

More...RefSeqi		NP_082661.1, NM_028385.1 [Q5XJV7-1]
NP_766593.1, NM_173005.1 [Q5XJV7-2]
XP_011239784.1, XM_011241482.2 [Q5XJV7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000042889; ENSMUSP00000047398; ENSMUSG00000034269 [Q5XJV7-1]
ENSMUST00000113155; ENSMUSP00000108780; ENSMUSG00000034269 [Q5XJV7-2]
ENSMUST00000113157; ENSMUSP00000108782; ENSMUSG00000034269 [Q5XJV7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		72895

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:72895

UCSC genome browser

More...UCSCi		uc009deq.1, mouse [Q5XJV7-1]
uc009der.1, mouse [Q5XJV7-2]
uc009deu.1, mouse [Q5XJV7-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122551 mRNA Translation: BAC65833.1 Different initiation.
AK049143 mRNA Translation: BAC33569.1 Different initiation.
AK053541 mRNA Translation: BAC35420.1
BC083184 mRNA Translation: AAH83184.1
CCDSiCCDS20411.1 [Q5XJV7-1]
CCDS90096.1 [Q5XJV7-2]
RefSeqiNP_082661.1, NM_028385.1 [Q5XJV7-1]
NP_766593.1, NM_173005.1 [Q5XJV7-2]
XP_011239784.1, XM_011241482.2 [Q5XJV7-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi215631, 6 interactors
IntActiQ5XJV7, 6 interactors
STRINGi10090.ENSMUSP00000047398

PTM databases

iPTMnetiQ5XJV7
PhosphoSitePlusiQ5XJV7

Proteomic databases

EPDiQ5XJV7
jPOSTiQ5XJV7
PaxDbiQ5XJV7
PeptideAtlasiQ5XJV7
PRIDEiQ5XJV7
ProteomicsDBi261498 [Q5XJV7-1]
261499 [Q5XJV7-2]
261500 [Q5XJV7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		60053, 89 antibodies

The DNASU plasmid repository

More...DNASUi		72895

Genome annotation databases

EnsembliENSMUST00000042889; ENSMUSP00000047398; ENSMUSG00000034269 [Q5XJV7-1]
ENSMUST00000113155; ENSMUSP00000108780; ENSMUSG00000034269 [Q5XJV7-2]
ENSMUST00000113157; ENSMUSP00000108782; ENSMUSG00000034269 [Q5XJV7-2]
GeneIDi72895
KEGGimmu:72895
UCSCiuc009deq.1, mouse [Q5XJV7-1]
uc009der.1, mouse [Q5XJV7-2]
uc009deu.1, mouse [Q5XJV7-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55209
MGIiMGI:1920145, Setd5
VEuPathDBiHostDB:ENSMUSG00000034269

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG1844, Eukaryota
GeneTreeiENSGT00940000157446
HOGENOMiCLU_002373_0_0_1
InParanoidiQ5XJV7
OMAiEPSPTWD
OrthoDBi86638at2759
PhylomeDBiQ5XJV7
TreeFamiTF106417

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		72895, 8 hits in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Setd5, mouse

Protein Ontology

More...PROi		PR:Q5XJV7
RNActiQ5XJV7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000034269, Expressed in undifferentiated genital tubercle and 287 other tissues
GenevisibleiQ5XJV7, MM

Family and domain databases

CDDicd19181, SET_SETD5, 1 hit
InterProiView protein in InterPro
IPR001214, SET_dom
IPR044433, SETD5_SET
PfamiView protein in Pfam
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM00317, SET, 1 hit
PROSITEiView protein in PROSITE
PS50280, SET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSETD5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5XJV7
Secondary accession number(s): Q80T94, Q8BKD5, Q8BX30
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 29, 2021
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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