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Entry version 136 (29 Sep 2021)
Sequence version 1 (23 Nov 2004)
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Protein

Serine/threonine-protein kinase LMTK3

Gene

Lmtk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity).

Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei164ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei266Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi139 – 147ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK3 (EC:2.7.11.1By similarity)
Alternative name(s):
Apoptosis-associated tyrosine kinase 3
Lemur tyrosine kinase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lmtk3
Synonyms:Aatyk3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3039582, Lmtk3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable and grossly normal. Mice exhibit prominent behavioral abnormalities, including locomotor hyperactivity, reduced anxiety, and decreased depression-like behavior.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi266D → V: Significant decrease in autophosphorylation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025946121 – 1424Serine/threonine-protein kinase LMTK3Add BLAST1404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei232PhosphoserineCombined sources1
Modified residuei490Omega-N-methylarginineCombined sources1
Modified residuei531PhosphoserineCombined sources1
Modified residuei535PhosphoserineCombined sources1
Modified residuei947PhosphoserineCombined sources1
Modified residuei962PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5XJV6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5XJV6

PRoteomics IDEntifications database

More...
PRIDEi
Q5XJV6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
292344

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5XJV6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5XJV6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain. Predominantly expressed in cerebral cortex, thalamus, the cerebellum and hippocampal formation (at protein level).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated during postnatal development, and expressed in adult stage.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ESR1 (By similarity).

Interacts with AP-2 complex subunit alpha (PubMed:24760852).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
238177, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q5XJV6, 5 interactors

Molecular INTeraction database

More...
MINTi
Q5XJV6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000112592

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5XJV6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5XJV6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini133 – 411Protein kinasePROSITE-ProRule annotationAdd BLAST279

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni74 – 95DisorderedSequence analysisAdd BLAST22
Regioni413 – 465DisorderedSequence analysisAdd BLAST53
Regioni486 – 516DisorderedSequence analysisAdd BLAST31
Regioni544 – 666DisorderedSequence analysisAdd BLAST123
Regioni680 – 964DisorderedSequence analysisAdd BLAST285
Regioni976 – 1024DisorderedSequence analysisAdd BLAST49
Regioni1041 – 1313DisorderedSequence analysisAdd BLAST273
Regioni1325 – 1424DisorderedSequence analysisAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi414 – 441Pro residuesSequence analysisAdd BLAST28
Compositional biasi552 – 572Pro residuesSequence analysisAdd BLAST21
Compositional biasi741 – 764Pro residuesSequence analysisAdd BLAST24
Compositional biasi820 – 843Pro residuesSequence analysisAdd BLAST24
Compositional biasi848 – 863Polar residuesSequence analysisAdd BLAST16
Compositional biasi932 – 957Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1115 – 1129Pro residuesSequence analysisAdd BLAST15
Compositional biasi1135 – 1153Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1165 – 1179Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1245 – 1261Acidic residuesSequence analysisAdd BLAST17
Compositional biasi1295 – 1313Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1326 – 1345Polar residuesSequence analysisAdd BLAST20
Compositional biasi1346 – 1363Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R1RA, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5XJV6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5XJV6

TreeFam database of animal gene trees

More...
TreeFami
TF332280

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109, TYRKINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q5XJV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAPGALILL AAVSASGCLA SPAHPDGFAL SRAPLAPPYA VVLISCSGLL
60 70 80 90 100
AFIFLLLTCL CCKRGDVRFK EFENPEGEDC SGEYTPPAEE TSSSQSLPDV
110 120 130 140 150
YILPLAEVSL PMPAPQPPHS DISTPLGLSR QHLSYLQEIG SGWFGKVILG
160 170 180 190 200
EVFSDYSPAQ VVVKELRASA GPLEQRKFIS EAQPYRSLQH PNVLQCLGVC
210 220 230 240 250
VETLPFLLIM EFCQLGDLKR YLRAQRPPEG MSPELPPRDL RTLQRMGLEI
260 270 280 290 300
ARGLAHLHSH NYVHSDLALR NCLLTSDLTV RIGDYGLAHS NYKEDYYLTP
310 320 330 340 350
ERLWVPLRWA APELLGELHG SFVLVDQSRE SNVWSLGVTL WELFEFGAQP
360 370 380 390 400
YRHLSDEEVL AFVVRQQHVK LARPRLKLPY ADYWYDILQS CWRPPAQRPS
410 420 430 440 450
ASDLQLQLTY LLSERPPRPP PPPPPPRDGP FPWPWPPSHS APRPGTLSSQ
460 470 480 490 500
FPLLDGFPGA DPDDVLTVTE SSRGLNLECL WEKARRGAGR GGGAPPWQPA
510 520 530 540 550
SAPPAPHTNP SNPFYEALST PSVLPVISAR SPSVSSEYYI RLEEHGSPPE
560 570 580 590 600
PLFPNDWDPL DPGVPGPQAP QTPSEVPQLV SETWASPLFP APRPFPAQSS
610 620 630 640 650
GSGGFLLSGW DPEGRGAGET LAGDPAEVLG EQGTAPWAEE EEEESSPGED
660 670 680 690 700
SSSLGGGPSR RGPLPCPLCS REGPCSCLPL ERGDAVAGWG DHPALGCPHP
710 720 730 740 750
PEDDSSLRAE RGSLADLPLV PPTSAPLEFL DPLMGAAAPQ YPGRGPPPAP
760 770 780 790 800
PPPPPPPRAS AEPAASPDPP SALASPGSGL SSPGPKPGDS GYETETPFSP
810 820 830 840 850
EGAFPGGGAA KEEGVPRPRA PPEPPDPGAP RPPPDPGPLP LPGSQEKPTF
860 870 880 890 900
VVQVSTEQLL MSLREDVTKN LLGDKGSTPG ETGPRKAGRS PANREKGPGP
910 920 930 940 950
NRDLTSLVSR KKVPSRSLPV NGVTVLENGK PGVPDMKEKV AENGLESPEK
960 970 980 990 1000
EERALVNGEP MSPEAGEKVL ANGVLMSPKS EEKVAENGVL RLPRNTERPP
1010 1020 1030 1040 1050
EIGPRRVPGP WEKTPETGGL APETLLDRAP APCEAALPQN GLEMAPGQLG
1060 1070 1080 1090 1100
PAPKSGNPDP GTEWRVHESG GAPRAPGAGK LDLGSGGRAL GGVGTAPAGG
1110 1120 1130 1140 1150
PASAVDAKAG WVDNSRPLPP PPQPLGAQQR RPEPVPLKAR PEVAQEEEPG
1160 1170 1180 1190 1200
VPDNRLGGDM APSVDEDPLK PERKGPEMPR LFLDLGPPQG NSEQIKAKLS
1210 1220 1230 1240 1250
RLSLALPPLT LTPFPGPGPR RPPWEGADAG AAGGEAGGAG APGPAEEDGE
1260 1270 1280 1290 1300
DEDEDEEDEE AAGSRDPGRT REAPVPVVVS SADGDTVRPL RGLLKSPRAA
1310 1320 1330 1340 1350
DEPEDSELER KRKMVSFHGD VTVYLFDQET PTNELSVQGT PEGDTEPSTP
1360 1370 1380 1390 1400
PAPPTPPHPT TPGDGFPNSD SGFGGSFEWA EDFPLLPPPG PPLCFSRFSV
1410 1420
SPALETPGPP ARAPDARPAG PVEN
Length:1,424
Mass (Da):150,891
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86A0BACC47909C91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0W7A0A0R4J0W7_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
1,424Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WCD2A0A3B2WCD2_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
1,446Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GRD8A0A1B0GRD8_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
202Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GSR5A0A1B0GSR5_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
1,450Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GSU1A0A1B0GSU1_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GR61A0A1B0GR61_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GSP4A0A1B0GSP4_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti691D → G in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti811K → E in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti811K → E in AAH94377 (PubMed:15489334).Curated1
Sequence conflicti941A → E in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti950K → R in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti1266D → G in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti1287V → A in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti1369S → N in BAF64834 (PubMed:17651901).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB288873 mRNA Translation: BAF64834.1
BC083185 mRNA Translation: AAH83185.1
BC094377 mRNA Translation: AAH94377.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39961.1

NCBI Reference Sequences

More...
RefSeqi
NP_001005511.2, NM_001005511.3
NP_001277919.1, NM_001290990.1
XP_006541027.1, XM_006540964.3
XP_017177816.1, XM_017322327.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
381983

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:381983

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB288873 mRNA Translation: BAF64834.1
BC083185 mRNA Translation: AAH83185.1
BC094377 mRNA Translation: AAH94377.1
CCDSiCCDS39961.1
RefSeqiNP_001005511.2, NM_001005511.3
NP_001277919.1, NM_001290990.1
XP_006541027.1, XM_006540964.3
XP_017177816.1, XM_017322327.1

3D structure databases

SMRiQ5XJV6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi238177, 4 interactors
IntActiQ5XJV6, 5 interactors
MINTiQ5XJV6
STRINGi10090.ENSMUSP00000112592

PTM databases

iPTMnetiQ5XJV6
PhosphoSitePlusiQ5XJV6

Proteomic databases

MaxQBiQ5XJV6
PaxDbiQ5XJV6
PRIDEiQ5XJV6
ProteomicsDBi292344

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
381983

Genome annotation databases

GeneIDi381983
KEGGimmu:381983

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114783
MGIiMGI:3039582, Lmtk3

Phylogenomic databases

eggNOGiENOG502R1RA, Eukaryota
InParanoidiQ5XJV6
PhylomeDBiQ5XJV6
TreeFamiTF332280

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
381983, 1 hit in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lmtk3, mouse

Protein Ontology

More...
PROi
PR:Q5XJV6
RNActiQ5XJV6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
PfamiView protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PRINTSiPR00109, TYRKINASE
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLMTK3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5XJV6
Secondary accession number(s): A6BLZ0, Q52KF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: September 29, 2021
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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