Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase LMTK3

Gene

Lmtk3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852).By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164ATPPROSITE-ProRule annotation1
Active sitei266Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi139 – 147ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK3 (EC:2.7.11.1By similarity)
Alternative name(s):
Apoptosis-associated tyrosine kinase 3
Lemur tyrosine kinase 3
Gene namesi
Name:Lmtk3
Synonyms:Aatyk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3039582 Lmtk3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Viable and grossly normal. Mice exhibit prominent behavioral abnormalities, including locomotor hyperactivity, reduced anxiety, and decreased depression-like behavior.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi266D → V: Significant decrease in autophosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025946121 – 1424Serine/threonine-protein kinase LMTK3Add BLAST1404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineCombined sources1
Modified residuei490Omega-N-methylarginineCombined sources1
Modified residuei531PhosphoserineCombined sources1
Modified residuei535PhosphoserineCombined sources1
Modified residuei947PhosphoserineCombined sources1
Modified residuei962PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ5XJV6
PaxDbiQ5XJV6
PRIDEiQ5XJV6

PTM databases

iPTMnetiQ5XJV6
PhosphoSitePlusiQ5XJV6

Expressioni

Tissue specificityi

Expressed in brain. Predominantly expressed in cerebral cortex, thalamus, the cerebellum and hippocampal formation (at protein level).2 Publications

Developmental stagei

Up-regulated during postnatal development, and expressed in adult stage.1 Publication

Gene expression databases

CleanExiMM_LMTK3

Interactioni

Subunit structurei

Interacts with ESR1 (By similarity). Interacts with AP-2 complex subunit alpha (PubMed:24760852).By similarity1 Publication

Protein-protein interaction databases

BioGridi238177, 3 interactors
IntActiQ5XJV6, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ5XJV6
SMRiQ5XJV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 411Protein kinasePROSITE-ProRule annotationAdd BLAST279

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi416 – 842Pro-richAdd BLAST427
Compositional biasi1117 – 1223Pro-richAdd BLAST107
Compositional biasi1347 – 1421Pro-richAdd BLAST75

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQE Eukaryota
ENOG410XQFM LUCA
HOGENOMiHOG000170369
HOVERGENiHBG081921
InParanoidiQ5XJV6
KOiK08899
PhylomeDBiQ5XJV6
TreeFamiTF332280

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q5XJV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAPGALILL AAVSASGCLA SPAHPDGFAL SRAPLAPPYA VVLISCSGLL
60 70 80 90 100
AFIFLLLTCL CCKRGDVRFK EFENPEGEDC SGEYTPPAEE TSSSQSLPDV
110 120 130 140 150
YILPLAEVSL PMPAPQPPHS DISTPLGLSR QHLSYLQEIG SGWFGKVILG
160 170 180 190 200
EVFSDYSPAQ VVVKELRASA GPLEQRKFIS EAQPYRSLQH PNVLQCLGVC
210 220 230 240 250
VETLPFLLIM EFCQLGDLKR YLRAQRPPEG MSPELPPRDL RTLQRMGLEI
260 270 280 290 300
ARGLAHLHSH NYVHSDLALR NCLLTSDLTV RIGDYGLAHS NYKEDYYLTP
310 320 330 340 350
ERLWVPLRWA APELLGELHG SFVLVDQSRE SNVWSLGVTL WELFEFGAQP
360 370 380 390 400
YRHLSDEEVL AFVVRQQHVK LARPRLKLPY ADYWYDILQS CWRPPAQRPS
410 420 430 440 450
ASDLQLQLTY LLSERPPRPP PPPPPPRDGP FPWPWPPSHS APRPGTLSSQ
460 470 480 490 500
FPLLDGFPGA DPDDVLTVTE SSRGLNLECL WEKARRGAGR GGGAPPWQPA
510 520 530 540 550
SAPPAPHTNP SNPFYEALST PSVLPVISAR SPSVSSEYYI RLEEHGSPPE
560 570 580 590 600
PLFPNDWDPL DPGVPGPQAP QTPSEVPQLV SETWASPLFP APRPFPAQSS
610 620 630 640 650
GSGGFLLSGW DPEGRGAGET LAGDPAEVLG EQGTAPWAEE EEEESSPGED
660 670 680 690 700
SSSLGGGPSR RGPLPCPLCS REGPCSCLPL ERGDAVAGWG DHPALGCPHP
710 720 730 740 750
PEDDSSLRAE RGSLADLPLV PPTSAPLEFL DPLMGAAAPQ YPGRGPPPAP
760 770 780 790 800
PPPPPPPRAS AEPAASPDPP SALASPGSGL SSPGPKPGDS GYETETPFSP
810 820 830 840 850
EGAFPGGGAA KEEGVPRPRA PPEPPDPGAP RPPPDPGPLP LPGSQEKPTF
860 870 880 890 900
VVQVSTEQLL MSLREDVTKN LLGDKGSTPG ETGPRKAGRS PANREKGPGP
910 920 930 940 950
NRDLTSLVSR KKVPSRSLPV NGVTVLENGK PGVPDMKEKV AENGLESPEK
960 970 980 990 1000
EERALVNGEP MSPEAGEKVL ANGVLMSPKS EEKVAENGVL RLPRNTERPP
1010 1020 1030 1040 1050
EIGPRRVPGP WEKTPETGGL APETLLDRAP APCEAALPQN GLEMAPGQLG
1060 1070 1080 1090 1100
PAPKSGNPDP GTEWRVHESG GAPRAPGAGK LDLGSGGRAL GGVGTAPAGG
1110 1120 1130 1140 1150
PASAVDAKAG WVDNSRPLPP PPQPLGAQQR RPEPVPLKAR PEVAQEEEPG
1160 1170 1180 1190 1200
VPDNRLGGDM APSVDEDPLK PERKGPEMPR LFLDLGPPQG NSEQIKAKLS
1210 1220 1230 1240 1250
RLSLALPPLT LTPFPGPGPR RPPWEGADAG AAGGEAGGAG APGPAEEDGE
1260 1270 1280 1290 1300
DEDEDEEDEE AAGSRDPGRT REAPVPVVVS SADGDTVRPL RGLLKSPRAA
1310 1320 1330 1340 1350
DEPEDSELER KRKMVSFHGD VTVYLFDQET PTNELSVQGT PEGDTEPSTP
1360 1370 1380 1390 1400
PAPPTPPHPT TPGDGFPNSD SGFGGSFEWA EDFPLLPPPG PPLCFSRFSV
1410 1420
SPALETPGPP ARAPDARPAG PVEN
Length:1,424
Mass (Da):150,891
Last modified:November 23, 2004 - v1
Checksum:i86A0BACC47909C91
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0W7A0A0R4J0W7_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
1,424Annotation score:
A0A1B0GRD8A0A1B0GRD8_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
202Annotation score:
A0A1B0GSR5A0A1B0GSR5_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
1,450Annotation score:
A0A1B0GSU1A0A1B0GSU1_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
161Annotation score:
A0A1B0GSP4A0A1B0GSP4_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
77Annotation score:
A0A1B0GR61A0A1B0GR61_MOUSE
Serine/threonine-protein kinase LMT...
Lmtk3
144Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti691D → G in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti811K → E in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti811K → E in AAH94377 (PubMed:15489334).Curated1
Sequence conflicti941A → E in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti950K → R in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti1266D → G in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti1287V → A in BAF64834 (PubMed:17651901).Curated1
Sequence conflicti1369S → N in BAF64834 (PubMed:17651901).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB288873 mRNA Translation: BAF64834.1
BC083185 mRNA Translation: AAH83185.1
BC094377 mRNA Translation: AAH94377.1
CCDSiCCDS39961.1
RefSeqiNP_001005511.2, NM_001005511.3
NP_001277919.1, NM_001290990.1
XP_006541027.1, XM_006540964.3
XP_017177816.1, XM_017322327.1
UniGeneiMm.44928
Mm.483301

Genome annotation databases

GeneIDi381983
KEGGimmu:381983

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB288873 mRNA Translation: BAF64834.1
BC083185 mRNA Translation: AAH83185.1
BC094377 mRNA Translation: AAH94377.1
CCDSiCCDS39961.1
RefSeqiNP_001005511.2, NM_001005511.3
NP_001277919.1, NM_001290990.1
XP_006541027.1, XM_006540964.3
XP_017177816.1, XM_017322327.1
UniGeneiMm.44928
Mm.483301

3D structure databases

ProteinModelPortaliQ5XJV6
SMRiQ5XJV6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi238177, 3 interactors
IntActiQ5XJV6, 3 interactors

PTM databases

iPTMnetiQ5XJV6
PhosphoSitePlusiQ5XJV6

Proteomic databases

MaxQBiQ5XJV6
PaxDbiQ5XJV6
PRIDEiQ5XJV6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi381983
KEGGimmu:381983

Organism-specific databases

CTDi114783
MGIiMGI:3039582 Lmtk3

Phylogenomic databases

eggNOGiENOG410IGQE Eukaryota
ENOG410XQFM LUCA
HOGENOMiHOG000170369
HOVERGENiHBG081921
InParanoidiQ5XJV6
KOiK08899
PhylomeDBiQ5XJV6
TreeFamiTF332280

Miscellaneous databases

PROiPR:Q5XJV6
SOURCEiSearch...

Gene expression databases

CleanExiMM_LMTK3

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLMTK3_MOUSE
AccessioniPrimary (citable) accession number: Q5XJV6
Secondary accession number(s): A6BLZ0, Q52KF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again