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Protein

Myeloid differentiation primary response protein MyD88

Gene

myd88

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response.1 Publication

GO - Molecular functioni

GO - Biological processi

  • activation of innate immune response Source: ZFIN
  • defense response to bacterium Source: ZFIN
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: ZFIN
  • monocyte activation Source: ZFIN
  • MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  • neutrophil activation involved in immune response Source: ZFIN
  • neutrophil chemotaxis Source: ZFIN
  • positive regulation of hematopoietic progenitor cell differentiation Source: ZFIN
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: InterPro
  • regulation of hematopoietic progenitor cell differentiation Source: ZFIN
  • response to molecule of bacterial origin Source: ZFIN

Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Myeloid differentiation primary response protein MyD88
Gene namesi
Name:myd88
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040219-3 myd88

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003931411 – 284Myeloid differentiation primary response protein MyD88Add BLAST284

Proteomic databases

PaxDbiQ5XJ85

Expressioni

Developmental stagei

Expression is highest in adults. In the embryo, maternal transcript levels are reduced during blastula and gastrula stages. Expression increases during segmentation and later stages.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000020711

Structurei

3D structure databases

SMRiQ5XJ85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 101DeathPROSITE-ProRule annotationAdd BLAST78
Domaini147 – 284TIRPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 143Intermediate domainBy similarityAdd BLAST42

Domaini

The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.By similarity

Phylogenomic databases

eggNOGiENOG410IIN8 Eukaryota
ENOG410ZIY0 LUCA
HOGENOMiHOG000068971
HOVERGENiHBG052547
InParanoidiQ5XJ85
KOiK04729
PhylomeDBiQ5XJ85
TreeFamiTF326264

Family and domain databases

CDDicd08312 Death_MyD88, 1 hit
Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR034249 MyD88_Death
IPR017281 Myelin_different_resp_MyD88
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR15079 PTHR15079, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF01582 TIR, 1 hit
PIRSFiPIRSF037756 MyD88, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XJ85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKLSIDHE AIPVTALNCS FRKKLGLFLN PTNTVAADWR TVAELMDFTY
60 70 80 90 100
LEIKNFEKRD CPFEKVLTDW ETRPDATVAN LLSILEKAER KDVISELKEI
110 120 130 140 150
LDDDCRKYME RQQRKPLQVP VVDSCGPRTQ EREGITLYDD PQGLTPETFD
160 170 180 190 200
AFICYCQSDI QFVHEMIKQL EHTEYNLKLC VFDRDVLPGT CVWTIASELI
210 220 230 240 250
EKRCKRMVVV ISDDYLDSDA CDFQTKFALS LCPGARTKRL IPVVYKSMKR
260 270 280
PFPSILRFLT ICDYSKPCTQ VWFWTRLAKA LSLP
Length:284
Mass (Da):32,874
Last modified:March 23, 2010 - v2
Checksum:i2A8A843356BD4203
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7I → L in AAQ90476 (PubMed:14687934).Curated1
Sequence conflicti60D → E in AAZ16494 (PubMed:16552074).Curated1
Sequence conflicti135I → V in AAH83419 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY388401 mRNA Translation: AAQ90476.1
AY389463 mRNA Translation: AAQ91324.1
DQ100359 mRNA Translation: AAZ16494.1
BC083419 mRNA Translation: AAH83419.1
RefSeqiNP_997979.2, NM_212814.2
UniGeneiDr.134592

Genome annotation databases

GeneIDi403145
KEGGidre:403145

Similar proteinsi

Entry informationi

Entry nameiMYD88_DANRE
AccessioniPrimary (citable) accession number: Q5XJ85
Secondary accession number(s): Q45VT5, Q6TQG4, Q6TS40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: May 23, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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