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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

mettl1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei137S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Active sitei140UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
Methyltransferase-like protein 1UniRule annotation
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:mettl1
ORF Names:zgc:103636
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 11

Organism-specific databases

ZFINiZDB-GENE-041010-24 mettl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003705581 – 241tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST241

Proteomic databases

PaxDbiQ5XJ57

Expressioni

Gene expression databases

BgeeiENSDARG00000076518

Interactioni

Subunit structurei

Forms a complex with wdr4.UniRule annotation

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101871

Structurei

3D structure databases

SMRiQ5XJ57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 85S-adenosyl-L-methionine bindingUniRule annotation2
Regioni117 – 118S-adenosyl-L-methionine bindingUniRule annotation2
Regioni215 – 217S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3115 Eukaryota
COG0220 LUCA
GeneTreeiENSGT00390000017840
HOGENOMiHOG000260965
InParanoidiQ5XJ57
KOiK03439
OMAiIGMEIRV
OrthoDBiEOG091G0IQ7
TreeFamiTF314083

Family and domain databases

HAMAPiMF_03055 tRNA_methyltr_TrmB_euk, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025763 Trm8_euk
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
PTHR23417:SF16 PTHR23417:SF16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XJ57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVCMPQKRY YRQRAHSNPM ADHTFQYPVC PEQMDWSPLY PQYFPQQEEA
60 70 80 90 100
GGAQVEFADI GCGYGGLLVQ LSQLFPQQLI LGLEIRVKVS DYVQDRIRSL
110 120 130 140 150
RVAEPGRYQN IACLRSNAMK YLPNFFRKGQ LSKMFFLFPD PHFKKTKHKW
160 170 180 190 200
RIISPTLLAE YAYTLRIGGL VYTNTDVEEV HEWIVQHFSD HPLFSRVTEE
210 220 230 240
QLADDIIVGH LGTCTEEGKK VQRNGGKNFL AVFRRVEDPQ T
Length:241
Mass (Da):27,966
Last modified:October 16, 2013 - v2
Checksum:i69B0FE8B16F64E8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73Q → L in AAI52159 (Ref. 2) Curated1
Sequence conflicti189S → G in AAH83450 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01008506 Genomic DNA No translation available.
CABZ01061933 Genomic DNA No translation available.
CABZ01061934 Genomic DNA No translation available.
CU929297 Genomic DNA No translation available.
BC083450 mRNA Translation: AAH83450.1
BC152158 mRNA Translation: AAI52159.1
RefSeqiNP_001005952.1, NM_001005952.1
XP_005155729.1, XM_005155672.3
XP_005155730.1, XM_005155673.3
XP_009303993.1, XM_009305718.2
UniGeneiDr.28333

Genome annotation databases

EnsembliENSDART00000109091; ENSDARP00000101871; ENSDARG00000076518
ENSDART00000154425; ENSDARP00000128994; ENSDARG00000076518
GeneIDi449779
KEGGidre:449779

Similar proteinsi

Entry informationi

Entry nameiTRMB_DANRE
AccessioniPrimary (citable) accession number: Q5XJ57
Secondary accession number(s): A7MCF3, F1QU80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 16, 2013
Last modified: June 20, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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