The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q5XIU2 (ZN143_RAT)
Protein
Zinc finger protein 143
Gene
Znf143
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 237 – 261 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 267 – 291 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 297 – 321 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 327 – 351 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 357 – 381 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 387 – 411 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 417 – 440 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- chromatin binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- positive regulation of smooth muscle cell proliferation Source: RGD
- positive regulation of snRNA transcription by RNA polymerase II Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 143Short name: Zfp-143 Alternative name(s): Selenocysteine tRNA gene transcription-activating factor |
Gene namesi | Name:Znf143 Synonyms:Staf, Zfp143 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1305662, Zfp143 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000248072 | 1 – 638 | Zinc finger protein 143Add BLAST | 638 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Cross-linki | 213 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 352 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 406 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q5XIU2 |
PRIDEi | Q5XIU2 |
PTM databases
iPTMneti | Q5XIU2 |
PhosphoSitePlusi | Q5XIU2 |
Interactioni
Subunit structurei
Interacts with CHD8.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000013733 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GLI C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 237 – 261 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 267 – 291 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 297 – 321 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 327 – 351 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 357 – 381 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 387 – 411 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 417 – 440 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_027168_0_0_1 |
InParanoidi | Q5XIU2 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5XIU2 |
TreeFami | TF333498 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5XIU2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL
60 70 80 90 100
QAVTLADGST AYIQHNSKDG RLIDGQVIQL EDGSAAYVQH VPIPKSTGDS
110 120 130 140 150
LRLEDGQAVQ LEDGTTAFIH HTSKDSYDQS SLQAVQLEDG TTAYIHHAVQ
160 170 180 190 200
VPQPDTILAI QADGTVAGLH TGDATIDPDT ISALEQYAAK VSIDGSEGVT
210 220 230 240 250
STGLIGENEQ EKKMQIVLQG HATRVTPKSQ QSGEKAFRCK YDGCGKLYTT
260 270 280 290 300
AHHLKVHERS HTGDRPYQCE HSGCGKAFAT GYGLKSHFRT HTGEKPYRCS
310 320 330 340 350
EDNCTKSFKT SGDLQKHIRT HTGERPFKCP IEGCGRSFTT SNIRKVHIRT
360 370 380 390 400
HTGERPYYCT EPGCGRAFAS ATNYKNHVRI HTGEKPYVCT VPGCDKRFTE
410 420 430 440 450
YSSLYKHHVV HTHSKPYNCN HCGKTYKQIS TLAMHKRTAH NDTEPIEEEQ
460 470 480 490 500
EAFFEPPPGQ GDDVLKGSQI TYVTGVEGED IVSTQVATVT QSGLSQQVTL
510 520 530 540 550
ISQDGTQHVN ISQADMQAIG NTITMVTQDG TPITVPTHDA VISSAGTHSV
560 570 580 590 600
AMVTAEGTEG QQVAIVAQDL AAFHAASSEM GHQPHSHHLV TTETRPLTLV
610 620 630
ATSNGTQIAV QLGEQPSLEE AIRIASRIQQ GETPGLDD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UHI0 | A0A0H2UHI0_RAT | Zinc finger protein 143 | Zfp143 | 626 | Annotation score: | ||
A0A8I5Y9N4 | A0A8I5Y9N4_RAT | RCG39986, isoform CRA_b | Zfp143 rCG_39986 | 610 | Annotation score: |
Sequence cautioni
The sequence AAH83578 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083578 mRNA Translation: AAH83578.1 Different initiation. |
RefSeqi | NP_001012169.1, NM_001012169.1 |
Genome annotation databases
Ensembli | ENSRNOT00000013733; ENSRNOP00000013733; ENSRNOG00000010087 |
GeneIDi | 361627 |
KEGGi | rno:361627 |
UCSCi | RGD:1305662, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083578 mRNA Translation: AAH83578.1 Different initiation. |
RefSeqi | NP_001012169.1, NM_001012169.1 |
3D structure databases
AlphaFoldDBi | Q5XIU2 |
SMRi | Q5XIU2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000013733 |
PTM databases
iPTMneti | Q5XIU2 |
PhosphoSitePlusi | Q5XIU2 |
Proteomic databases
PaxDbi | Q5XIU2 |
PRIDEi | Q5XIU2 |
Genome annotation databases
Ensembli | ENSRNOT00000013733; ENSRNOP00000013733; ENSRNOG00000010087 |
GeneIDi | 361627 |
KEGGi | rno:361627 |
UCSCi | RGD:1305662, rat |
Organism-specific databases
CTDi | 20841 |
RGDi | 1305662, Zfp143 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_027168_0_0_1 |
InParanoidi | Q5XIU2 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5XIU2 |
TreeFami | TF333498 |
Enzyme and pathway databases
Reactomei | R-RNO-212436, Generic Transcription Pathway |
Miscellaneous databases
PROi | PR:Q5XIU2 |
Gene expression databases
Genevisiblei | Q5XIU2, RN |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN143_RAT | |
Accessioni | Q5XIU2Primary (citable) accession number: Q5XIU2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | May 5, 2009 | |
Last modified: | May 25, 2022 | |
This is version 123 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families