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Protein

Zinc finger protein 143

Gene

Znf143

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri267 – 291C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri297 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri327 – 351C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri357 – 381C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri387 – 411C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri417 – 440C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • chromatin binding Source: RGD
  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • positive regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 143
Short name:
Zfp-143
Alternative name(s):
Selenocysteine tRNA gene transcription-activating factor
Gene namesi
Name:Znf143
Synonyms:Staf, Zfp143
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305662 Zfp143

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002480721 – 638Zinc finger protein 143Add BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki213Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei352PhosphothreonineBy similarity1
Cross-linki406Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5XIU2
PRIDEiQ5XIU2

PTM databases

iPTMnetiQ5XIU2
PhosphoSitePlusiQ5XIU2

Expressioni

Gene expression databases

GenevisibleiQ5XIU2 RN

Interactioni

Subunit structurei

Interacts with CHD8.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013733

Structurei

3D structure databases

SMRiQ5XIU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri267 – 291C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri297 – 321C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri327 – 351C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri357 – 381C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri387 – 411C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri417 – 440C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000118073
HOVERGENiHBG053078
InParanoidiQ5XIU2
KOiK20828
OrthoDBiEOG091G0N38
PhylomeDBiQ5XIU2
TreeFamiTF333498

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5XIU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL
60 70 80 90 100
QAVTLADGST AYIQHNSKDG RLIDGQVIQL EDGSAAYVQH VPIPKSTGDS
110 120 130 140 150
LRLEDGQAVQ LEDGTTAFIH HTSKDSYDQS SLQAVQLEDG TTAYIHHAVQ
160 170 180 190 200
VPQPDTILAI QADGTVAGLH TGDATIDPDT ISALEQYAAK VSIDGSEGVT
210 220 230 240 250
STGLIGENEQ EKKMQIVLQG HATRVTPKSQ QSGEKAFRCK YDGCGKLYTT
260 270 280 290 300
AHHLKVHERS HTGDRPYQCE HSGCGKAFAT GYGLKSHFRT HTGEKPYRCS
310 320 330 340 350
EDNCTKSFKT SGDLQKHIRT HTGERPFKCP IEGCGRSFTT SNIRKVHIRT
360 370 380 390 400
HTGERPYYCT EPGCGRAFAS ATNYKNHVRI HTGEKPYVCT VPGCDKRFTE
410 420 430 440 450
YSSLYKHHVV HTHSKPYNCN HCGKTYKQIS TLAMHKRTAH NDTEPIEEEQ
460 470 480 490 500
EAFFEPPPGQ GDDVLKGSQI TYVTGVEGED IVSTQVATVT QSGLSQQVTL
510 520 530 540 550
ISQDGTQHVN ISQADMQAIG NTITMVTQDG TPITVPTHDA VISSAGTHSV
560 570 580 590 600
AMVTAEGTEG QQVAIVAQDL AAFHAASSEM GHQPHSHHLV TTETRPLTLV
610 620 630
ATSNGTQIAV QLGEQPSLEE AIRIASRIQQ GETPGLDD
Length:638
Mass (Da):68,999
Last modified:May 5, 2009 - v2
Checksum:i437CB9B2D77D37DF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UHI0A0A0H2UHI0_RAT
Zinc finger protein 143
Zfp143
626Annotation score:

Sequence cautioni

The sequence AAH83578 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083578 mRNA Translation: AAH83578.1 Different initiation.
RefSeqiNP_001012169.1, NM_001012169.1
UniGeneiRn.105662

Genome annotation databases

GeneIDi361627
KEGGirno:361627
UCSCiRGD:1305662 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083578 mRNA Translation: AAH83578.1 Different initiation.
RefSeqiNP_001012169.1, NM_001012169.1
UniGeneiRn.105662

3D structure databases

SMRiQ5XIU2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013733

PTM databases

iPTMnetiQ5XIU2
PhosphoSitePlusiQ5XIU2

Proteomic databases

PaxDbiQ5XIU2
PRIDEiQ5XIU2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361627
KEGGirno:361627
UCSCiRGD:1305662 rat

Organism-specific databases

CTDi20841
RGDi1305662 Zfp143

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000118073
HOVERGENiHBG053078
InParanoidiQ5XIU2
KOiK20828
OrthoDBiEOG091G0N38
PhylomeDBiQ5XIU2
TreeFamiTF333498

Miscellaneous databases

PROiPR:Q5XIU2

Gene expression databases

GenevisibleiQ5XIU2 RN

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN143_RAT
AccessioniPrimary (citable) accession number: Q5XIU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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