Znf143

Functionⁱ

Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	237 – 261	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	267 – 291	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	297 – 321	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	327 – 351	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	357 – 381	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	387 – 411	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	417 – 440	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

chromatin binding
Source: RGD
Inferred from direct assayⁱ
- 21352097
DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of smooth muscle cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 21352097
positive regulation of transcription by RNA polymerase II
Source: RGD
Inferred from mutant phenotypeⁱ
- 21352097

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 143 Short name: Zfp-143 Alternative name(s): Selenocysteine tRNA gene transcription-activating factor
Gene namesⁱ	Name:Znf143 Synonyms:Staf, Zfp143
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	1305662 Zfp143

RGDⁱ

1305662 Zfp143

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000248072	1 – 638	Zinc finger protein 143Add BLAST		638

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Cross-linkⁱ	213	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	352	PhosphothreonineBy similarity	1
Cross-linkⁱ	406	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q5XIU2
PRIDEⁱ	Q5XIU2

PTM databases

iPTMnetⁱ	Q5XIU2
PhosphoSitePlusⁱ	Q5XIU2

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q5XIU2 RN

Genevisibleⁱ

Q5XIU2 RN

Interactionⁱ

Subunit structureⁱ

Interacts with CHD8.By similarity

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000013733

STRINGⁱ

10116.ENSRNOP00000013733

Structureⁱ

3D structure databases

SMRⁱ	Q5XIU2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GLI C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	237 – 261	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	267 – 291	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	297 – 321	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	327 – 351	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	357 – 381	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	387 – 411	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	417 – 440	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOGENOMⁱ	HOG000118073
HOVERGENⁱ	HBG053078
InParanoidⁱ	Q5XIU2
KEGG Orthology (KO) More...KOⁱ	K20828
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N38
PhylomeDBⁱ	Q5XIU2
TreeFamⁱ	TF333498

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q5XIU2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLAQINRDS QGMTEFPGGG MEAQHVTLCL TEAVTVADGD NLENMEGVSL 
        60         70         80         90        100
QAVTLADGST AYIQHNSKDG RLIDGQVIQL EDGSAAYVQH VPIPKSTGDS 
       110        120        130        140        150
LRLEDGQAVQ LEDGTTAFIH HTSKDSYDQS SLQAVQLEDG TTAYIHHAVQ 
       160        170        180        190        200
VPQPDTILAI QADGTVAGLH TGDATIDPDT ISALEQYAAK VSIDGSEGVT 
       210        220        230        240        250
STGLIGENEQ EKKMQIVLQG HATRVTPKSQ QSGEKAFRCK YDGCGKLYTT 
       260        270        280        290        300
AHHLKVHERS HTGDRPYQCE HSGCGKAFAT GYGLKSHFRT HTGEKPYRCS 
       310        320        330        340        350
EDNCTKSFKT SGDLQKHIRT HTGERPFKCP IEGCGRSFTT SNIRKVHIRT 
       360        370        380        390        400
HTGERPYYCT EPGCGRAFAS ATNYKNHVRI HTGEKPYVCT VPGCDKRFTE 
       410        420        430        440        450
YSSLYKHHVV HTHSKPYNCN HCGKTYKQIS TLAMHKRTAH NDTEPIEEEQ 
       460        470        480        490        500
EAFFEPPPGQ GDDVLKGSQI TYVTGVEGED IVSTQVATVT QSGLSQQVTL 
       510        520        530        540        550
ISQDGTQHVN ISQADMQAIG NTITMVTQDG TPITVPTHDA VISSAGTHSV 
       560        570        580        590        600
AMVTAEGTEG QQVAIVAQDL AAFHAASSEM GHQPHSHHLV TTETRPLTLV 
       610        620        630 
ATSNGTQIAV QLGEQPSLEE AIRIASRIQQ GETPGLDD

Length:638

Mass (Da):68,999

Last modified:May 5, 2009 - v2

Checksum:ⁱ437CB9B2D77D37DF

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0H2UHI0	A0A0H2UHI0_RAT		Zinc finger protein 143 Zinc finger protein 143	Zfp143	626	Annotation score:

Sequence cautionⁱ

The sequence AAH83578 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC083578 mRNA Translation: AAH83578.1 Different initiation.
NCBI Reference Sequences More...RefSeqⁱ	NP_001012169.1, NM_001012169.1
UniGeneⁱ	Rn.105662

Genome annotation databases

GeneIDⁱ	361627
KEGGⁱ	rno:361627
UCSC genome browser More...UCSCⁱ	RGD:1305662 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5XIU2	Zinc finger protein 143		RAT		626	UniRef100_Q5XIU2

Protein	Similar proteins		Species	Score	Length	Source
Q5XIU2	Zinc finger protein 143		HUMAN		638	UniRef90_P52747
Zinc finger protein 143		MOUSE		638
Uncharacterized protein		AOTNA		729
ZNF143 isoform 15 (Fragment)		PONAB		73
ZNF143 (Fragment)		CEREH		102
+358

Protein	Similar proteins		Species	Score	Length	Source
Q5XIU2	Zinc finger protein 143		HUMAN		638	UniRef50_P52747
Zinc finger protein 143		MOUSE		638
Zinc finger protein 143		DANRE		623
Zinc finger protein 143		BOVIN		613
Zinc finger protein 143		XENLA		565
+749

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC083578 mRNA Translation: AAH83578.1 Different initiation.
RefSeqⁱ	NP_001012169.1, NM_001012169.1
UniGeneⁱ	Rn.105662

3D structure databases

SMRⁱ	Q5XIU2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000013733

STRINGⁱ

10116.ENSRNOP00000013733

PTM databases

iPTMnetⁱ	Q5XIU2
PhosphoSitePlusⁱ	Q5XIU2

Proteomic databases

PaxDbⁱ	Q5XIU2
PRIDEⁱ	Q5XIU2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	361627
KEGGⁱ	rno:361627
UCSCⁱ	RGD:1305662 rat

Organism-specific databases

CTDⁱ	20841
RGDⁱ	1305662 Zfp143

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
HOGENOMⁱ	HOG000118073
HOVERGENⁱ	HBG053078
InParanoidⁱ	Q5XIU2
KOⁱ	K20828
OrthoDBⁱ	EOG091G0N38
PhylomeDBⁱ	Q5XIU2
TreeFamⁱ	TF333498

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q5XIU2

PROⁱ

PR:Q5XIU2

Gene expression databases

Genevisibleⁱ	Q5XIU2 RN

Genevisibleⁱ

Q5XIU2 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN143_RAT
Accessionⁱ	Q5XIU2Primary (citable) accession number: Q5XIU2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
	Last sequence update:	May 5, 2009
	Last modified:	November 7, 2018
	This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5XIU2 (ZN143_RAT)

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Zinc finger protein 143

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ