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Protein

ELMO domain-containing protein 3

Gene

Elmod3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity.By similarity

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
ELMO domain-containing protein 3
Alternative name(s):
RNA-binding motif and ELMO domain-containing protein 1
Gene namesi
Name:Elmod3
Synonyms:Rbed1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1306408 Elmod3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002749051 – 356ELMO domain-containing protein 3Add BLAST356

Proteomic databases

PaxDbiQ5XIQ2
PRIDEiQ5XIQ2

Expressioni

Tissue specificityi

Expressed in the cochlea and in the organ of Corti, as well as in the supporting cells, including pillar and Dieters' cells (at protein level).1 Publication

Developmental stagei

At P02, in the organ of Corti, expressed in the stereocilia of outer hair cells and in the kinocilia of both outer and inner hair cells. Also concentrated at the cuticular plate level of auditory hair cells. However, before P07, expression in the inner hair cell stereocilia is very weak. By P07, in auditory hair cells, patchy expression detected along the length of stereocilia, but absent from the very tip. Later in development, detected in the stereocilia bundles and microvilli of sensory cells and also in the supporting cell bodies (at protein level).

Gene expression databases

BgeeiENSRNOG00000038102 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiQ5XIQ2 baseline and differential
GenevisibleiQ5XIQ2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054799

Structurei

3D structure databases

SMRiQ5XIQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 324ELMOPROSITE-ProRule annotationAdd BLAST155

Phylogenomic databases

eggNOGiKOG2998 Eukaryota
ENOG410XRXC LUCA
GeneTreeiENSGT00390000009488
HOVERGENiHBG054776
InParanoidiQ5XIQ2
PhylomeDBiQ5XIQ2

Family and domain databases

InterProiView protein in InterPro
IPR006816 ELMO_dom
IPR030731 ELMOD3
PANTHERiPTHR12771:SF2 PTHR12771:SF2, 1 hit
PfamiView protein in Pfam
PF04727 ELMO_CED12, 1 hit
PROSITEiView protein in PROSITE
PS51335 ELMO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5XIQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETSCSFLI EKEFQDGQVE SVSAGLSPSY KDNGALMAFR GIPISELKNH
60 70 80 90 100
GILQVLTAET NGWQPGVVSA EMLRAQEEWE VVDTIHPDIE SGVSSQQPGQ
110 120 130 140 150
FISFNEALEH FQTVDLSSFK KRIQPTIQRT GLAALRHCLF GPPKLHQGLQ
160 170 180 190 200
EERDLVLTIA QCGLDSQNPT HGRVLQTIYK KLTGSKFDCA LHGDHWEDLG
210 220 230 240 250
FQGANPATDL RGTGFLALLH LLYLVMDSKT LLMAQEILRL SHHHIQQFPF
260 270 280 290 300
CLMSVNITRI AIQALREECL SRECNRRRKV IPVVNSFYAA TFLHLARMWR
310 320 330 340 350
TQHNTILDSG FVLKELGIEP RALRSIGKRS TAELNPQPAP AFLVWDYSRA

FMHGSR
Length:356
Mass (Da):40,014
Last modified:November 23, 2004 - v1
Checksum:iF6110762B75E4EBF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2KBB8A0A0G2KBB8_RAT
ELMO domain-containing protein 3
Elmod3
381Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083623 mRNA Translation: AAH83623.1
RefSeqiNP_001013105.1, NM_001013087.1
UniGeneiRn.203170

Genome annotation databases

EnsembliENSRNOT00000057989; ENSRNOP00000054799; ENSRNOG00000038102
GeneIDi297342
KEGGirno:297342
UCSCiRGD:1306408 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083623 mRNA Translation: AAH83623.1
RefSeqiNP_001013105.1, NM_001013087.1
UniGeneiRn.203170

3D structure databases

SMRiQ5XIQ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054799

Proteomic databases

PaxDbiQ5XIQ2
PRIDEiQ5XIQ2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057989; ENSRNOP00000054799; ENSRNOG00000038102
GeneIDi297342
KEGGirno:297342
UCSCiRGD:1306408 rat

Organism-specific databases

CTDi84173
RGDi1306408 Elmod3

Phylogenomic databases

eggNOGiKOG2998 Eukaryota
ENOG410XRXC LUCA
GeneTreeiENSGT00390000009488
HOVERGENiHBG054776
InParanoidiQ5XIQ2
PhylomeDBiQ5XIQ2

Miscellaneous databases

PROiPR:Q5XIQ2

Gene expression databases

BgeeiENSRNOG00000038102 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiQ5XIQ2 baseline and differential
GenevisibleiQ5XIQ2 RN

Family and domain databases

InterProiView protein in InterPro
IPR006816 ELMO_dom
IPR030731 ELMOD3
PANTHERiPTHR12771:SF2 PTHR12771:SF2, 1 hit
PfamiView protein in Pfam
PF04727 ELMO_CED12, 1 hit
PROSITEiView protein in PROSITE
PS51335 ELMO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELMD3_RAT
AccessioniPrimary (citable) accession number: Q5XIQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 23, 2004
Last modified: September 12, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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