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Protein

Mitochondrial proton/calcium exchanger protein

Gene

Letm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity).By similarity

Activity regulationi

Inhibited by ruthenium red or its derivative Ru360.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi675 – 687Sequence analysisAdd BLAST13

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial proton/calcium exchanger proteinCurated
Alternative name(s):
Leucine zipper-EF-hand-containing transmembrane protein 1
Gene namesi
Name:Letm1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1359678 Letm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini115 – 207Mitochondrial intermembraneSequence analysisAdd BLAST93
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 739Mitochondrial matrixSequence analysisAdd BLAST511

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 114MitochondrionSequence analysisAdd BLAST114
ChainiPRO_0000017696115 – 739Mitochondrial proton/calcium exchanger proteinAdd BLAST625

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei596N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5XIN6
PRIDEiQ5XIN6

PTM databases

CarbonylDBiQ5XIN6
iPTMnetiQ5XIN6
PhosphoSitePlusiQ5XIN6

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSRNOG00000016427 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ5XIN6 RN

Interactioni

Subunit structurei

Homohexamer (By similarity). Interacts with BCS1L (By similarity).By similarity

Protein-protein interaction databases

BioGridi258178, 1 interactor
STRINGi10116.ENSRNOP00000022540

Structurei

3D structure databases

ProteinModelPortaliQ5XIN6
SMRiQ5XIN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 536Letm1 RBDPROSITE-ProRule annotationAdd BLAST286
Domaini663 – 698EF-handAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili115 – 135Sequence analysisAdd BLAST21
Coiled coili445 – 492Sequence analysisAdd BLAST48
Coiled coili537 – 626Sequence analysisAdd BLAST90
Coiled coili707 – 738Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the LETM1 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1043 Eukaryota
ENOG410XRSP LUCA
GeneTreeiENSGT00390000011225
HOGENOMiHOG000290246
HOVERGENiHBG052322
InParanoidiQ5XIN6
KOiK17800
OMAiARMTTEQ
OrthoDBiEOG091G034T
PhylomeDBiQ5XIN6
TreeFamiTF316321

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR011685 LETM1
IPR033122 LETM1_RBD
PfamiView protein in Pfam
PF07766 LETM1, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS51758 LETM1_RBD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASILLRSCR GRGPARLASP RAASPRGSLR DRACLSCTRT VGLTSHESVL
60 70 80 90 100
SRCCTPANPV YLYFKSEPLS CWTQRPECQG TVARAAWTPA SARLVVTGPQ
110 120 130 140 150
YLPVRGWHSS SPLGEDSMIE KSLKSLKDKN KKLEEGGPVY SPPAQVVVKK
160 170 180 190 200
SLGQKILDEL KHYYHGFRLL WIDTKIAARM LWRILNGHTL TRRERRQFLR
210 220 230 240 250
ICADLFRLVP FLVFVVVPFM EFLLPVVVKL FPNMLPSTFE TQSIKEERLK
260 270 280 290 300
KELRVKLELA KFLQDTIEEM ALKNKAAKGN ATKDFSAFFQ KIRETGERPS
310 320 330 340 350
NEEIMRFSKL FEDELTLDNL TRPQLVALCK LLELQSIGTN NFLRFQLTMR
360 370 380 390 400
LRSIKADDKL ISEEGVDSLT VKELQAACRA RGMRALGVTE DRLKGQLKQW
410 420 430 440 450
LDLHLYHEIP TSLLILSRAM YLPDTLSPAD QLKSTLQTLP EIVAKEAQVK
460 470 480 490 500
AAEVEGEQVD NKAKLEATLQ EEAAIQQEHL EELKRAAETA KDIQPEVAEA
510 520 530 540 550
TVPGRPGAEL QPKMVDVIPP SEILKDTAPV LEGLKGEEIT KEEIDILSDA
560 570 580 590 600
CSKLKEQKKS LTKEKEELEL LKEDVQDYSE DLQEIKKELS KTGDEKYIEE
610 620 630 640 650
STASKRLSKR VQQMIGQIDG LITQLETTQQ NGKLDPAAAS SPTGESVISV
660 670 680 690 700
DELISAMKQI KHIPEHKLIS LTSALDENKD GNINIDDLVK VIDLVNKEDV
710 720 730
QISTTQVAEI VATLEKEEKV EEKEKAKEKA EKEAAEVKN
Length:739
Mass (Da):83,060
Last modified:November 23, 2004 - v1
Checksum:i726DE7D0EAB54331
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083642 mRNA Translation: AAH83642.1
RefSeqiNP_001005884.1, NM_001005884.1
UniGeneiRn.162290

Genome annotation databases

EnsembliENSRNOT00000022540; ENSRNOP00000022540; ENSRNOG00000016427
GeneIDi305457
KEGGirno:305457

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083642 mRNA Translation: AAH83642.1
RefSeqiNP_001005884.1, NM_001005884.1
UniGeneiRn.162290

3D structure databases

ProteinModelPortaliQ5XIN6
SMRiQ5XIN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi258178, 1 interactor
STRINGi10116.ENSRNOP00000022540

PTM databases

CarbonylDBiQ5XIN6
iPTMnetiQ5XIN6
PhosphoSitePlusiQ5XIN6

Proteomic databases

PaxDbiQ5XIN6
PRIDEiQ5XIN6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022540; ENSRNOP00000022540; ENSRNOG00000016427
GeneIDi305457
KEGGirno:305457

Organism-specific databases

CTDi3954
RGDi1359678 Letm1

Phylogenomic databases

eggNOGiKOG1043 Eukaryota
ENOG410XRSP LUCA
GeneTreeiENSGT00390000011225
HOGENOMiHOG000290246
HOVERGENiHBG052322
InParanoidiQ5XIN6
KOiK17800
OMAiARMTTEQ
OrthoDBiEOG091G034T
PhylomeDBiQ5XIN6
TreeFamiTF316321

Miscellaneous databases

PROiPR:Q5XIN6

Gene expression databases

BgeeiENSRNOG00000016427 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ5XIN6 RN

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR011685 LETM1
IPR033122 LETM1_RBD
PfamiView protein in Pfam
PF07766 LETM1, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS51758 LETM1_RBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLETM1_RAT
AccessioniPrimary (citable) accession number: Q5XIN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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