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Protein

ATP synthase subunit s, mitochondrial

Gene

Atp5s

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H+ conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi93MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-163210 Formation of ATP by chemiosmotic coupling
R-RNO-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit s, mitochondrial
Alternative name(s):
ATP synthase-coupling factor B
Mitochondrial ATP synthase regulatory component factor B
Gene namesi
Name:Atp5s
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1359208 Atp5s

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000000254126 – 200ATP synthase subunit s, mitochondrialAdd BLAST175

Proteomic databases

PaxDbiQ5XIM4
PRIDEiQ5XIM4

PTM databases

iPTMnetiQ5XIM4
PhosphoSitePlusiQ5XIM4

Expressioni

Gene expression databases

BgeeiENSRNOG00000004893
GenevisibleiQ5XIM4 RN

Interactioni

Subunit structurei

Homotetramer. Associates with ATP synthase (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006509

Structurei

3D structure databases

ProteinModelPortaliQ5XIM4
SMRiQ5XIM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 87LRR 1Add BLAST26
Repeati88 – 116LRR 2Add BLAST29
Repeati117 – 141LRR 3Add BLAST25
Repeati142 – 173LRR 4Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 61N-terminal domainAdd BLAST61

Sequence similaritiesi

Belongs to the ATP synthase subunit s family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG3864 Eukaryota
ENOG4110375 LUCA
GeneTreeiENSGT00530000063680
HOGENOMiHOG000230741
HOVERGENiHBG050615
InParanoidiQ5XIM4
KOiK07554
OMAiIFHNCKH
OrthoDBiEOG091G0WCB
PhylomeDBiQ5XIM4
TreeFamiTF315274

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR026063 ATP_synth_s
IPR032675 LRR_dom_sf
PANTHERiPTHR13382:SF1 PTHR13382:SF1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMFGKISRQ LFSLKKIPWS CDSRYFWEWL NTVFNKVDYE RIKDVGPDRA
60 70 80 90 100
ASEWLLRCGA KVRYCGHQKW LQDYNKLPGG SVDRYKIQAI DATDSCIMDI
110 120 130 140 150
GFDHLVGLEH VERITLCRCH YIEDNCLQRL SQLENLRKSL LELEIIACGN
160 170 180 190 200
VTDNGVIALR HFKNLKYLFL SDLPGIKDKE YLAEVFTKAL PSLELKLNLK
Length:200
Mass (Da):23,324
Last modified:November 23, 2004 - v1
Checksum:i8EC195A78F6B3978
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083655 mRNA Translation: AAH83655.1
RefSeqiNP_001007750.1, NM_001007749.1
XP_006240236.1, XM_006240174.3
XP_006240237.1, XM_006240175.3
XP_006240238.1, XM_006240176.3
UniGeneiRn.106766

Genome annotation databases

EnsembliENSRNOT00000006509; ENSRNOP00000006509; ENSRNOG00000004893
GeneIDi362749
KEGGirno:362749
UCSCiRGD:1359208 rat

Similar proteinsi

Entry informationi

Entry nameiATP5S_RAT
AccessioniPrimary (citable) accession number: Q5XIM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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