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Protein

DNA-directed RNA polymerase III subunit RPC3

Gene

Polr3c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processAntiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

ReactomeiR-RNO-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-RNO-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-RNO-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC3
Short name:
RNA polymerase III subunit C3
Alternative name(s):
DNA-directed RNA polymerase III subunit C
Gene namesi
Name:Polr3c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1311545 Polr3c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002549061 – 533DNA-directed RNA polymerase III subunit RPC3Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5XIL3
PRIDEiQ5XIL3

Expressioni

Gene expression databases

BgeeiENSRNOG00000033560
GenevisibleiQ5XIL3 RN

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex (By similarity). Directly interacts with POLR3G and POLR3GL. Directly interacts with POLR3F/RPC39. Interacts with GTF3C4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028815

Structurei

3D structure databases

SMRiQ5XIL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2587 Eukaryota
ENOG410XPVH LUCA
GeneTreeiENSGT00390000002799
HOGENOMiHOG000046475
HOVERGENiHBG059543
InParanoidiQ5XIL3
KOiK03023
OMAiEQCFGKV
OrthoDBiEOG091G186Z
PhylomeDBiQ5XIL3
TreeFamiTF103048

Family and domain databases

Gene3Di1.10.10.10, 4 hits
InterProiView protein in InterPro
IPR013197 RNA_pol_III_RPC82-rel_HTH
IPR008806 RNA_pol_III_Rpc82_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF08221 HTH_9, 1 hit
PF05645 RNA_pol_Rpc82, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XIL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQAEIKLCS LLLQEHFGEI VEKIGVHLIR TGSQPLRVIA HDTKASLDQV
60 70 80 90 100
KKALCVLIHH NLVIYHVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYG
110 120 130 140 150
DTGELIVEEL LLNGKMTMSA VVKKVADRLT ETMEDGKTMD YAEVSNAFVR
160 170 180 190 200
LADTHFVQRC PLVPDTDSSD PGPPPPAPNL VINEKDMYLV PKLSLIGKGK
210 220 230 240 250
RRRSSDEDAA GEPKAKKPRC TDNEEPTPDD GIYWQVNLDR FHQHFRDQAI
260 270 280 290 300
VSAVANRMDQ TSSEIVRTML RMSEITTPSG APFTQPLSSN EIFRSLPVGY
310 320 330 340 350
NISKQVLDQY LTLLADDPLE FIGKAGDSGG GMYVINLHKA LASLSTATLE
360 370 380 390 400
SVIQERFGSR CARIFRLVLQ KKHLEQKQVE DFAMIPAKEA KDMLYKMLSE
410 420 430 440 450
NFISLQEIPK TPDHAPSRTF YLYTVNVLSA ARMLLHRCYK SIANLIERRQ
460 470 480 490 500
FETKENKRLL EKSQRVEAIM ASMQATGAEE VQLQEIEEMI TAPERQQLET
510 520 530
LKRNVNKLDA SEIQVDETIF LLESYIESTM KRQ
Length:533
Mass (Da):60,543
Last modified:November 23, 2004 - v1
Checksum:i6584FD72D4962312
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083667 mRNA Translation: AAH83667.1
RefSeqiNP_001012081.1, NM_001012081.1
XP_008759532.1, XM_008761310.2
UniGeneiRn.35251

Genome annotation databases

EnsembliENSRNOT00000028815; ENSRNOP00000028815; ENSRNOG00000033560
GeneIDi310685
KEGGirno:310685
UCSCiRGD:1311545 rat

Similar proteinsi

Entry informationi

Entry nameiRPC3_RAT
AccessioniPrimary (citable) accession number: Q5XIL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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