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Protein

Prohibitin-2

Gene

Phb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity).By similarity

GO - Biological processi

  • cellular response to hypoxia Source: RGD
  • cellular response to retinoic acid Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • response to wounding Source: RGD

Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-8949664 Processing of SMDT1

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin-2
Alternative name(s):
B-cell receptor-associated protein BAP37
Short name:
BAP-37
Gene namesi
Name:Phb2By similarity
Synonyms:Bcap37Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620203 Phb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002138862 – 299Prohibitin-2Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei128PhosphotyrosineBy similarity1
Modified residuei147N6-acetyllysineBy similarity1
Modified residuei151PhosphoserineCombined sources1
Modified residuei200N6-acetyllysineBy similarity1
Modified residuei236N6-acetyllysineBy similarity1
Modified residuei250N6-acetyllysineBy similarity1
Modified residuei262N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XIH7
PRIDEiQ5XIH7

PTM databases

CarbonylDBiQ5XIH7
iPTMnetiQ5XIH7
PhosphoSitePlusiQ5XIH7

Expressioni

Gene expression databases

BgeeiENSRNOG00000012999 Expressed in 9 organ(s), highest expression level in heart
ExpressionAtlasiQ5XIH7 baseline and differential
GenevisibleiQ5XIH7 RN

Interactioni

Subunit structurei

Interacts with PHB (PubMed:11302691). Interacts with ESR1, HDAC1 and HDAC5. Interacts with ZNF703. Interacts with STOML2. Interacts with ARFGEF3.By similarity1 Publication

Protein-protein interaction databases

BioGridi250411, 2 interactors
IntActiQ5XIH7, 3 interactors
MINTiQ5XIH7
STRINGi10116.ENSRNOP00000017472

Structurei

3D structure databases

ProteinModelPortaliQ5XIH7
SMRiQ5XIH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 49Necessary for transcriptional repressionBy similarityAdd BLAST31
Regioni150 – 174Necessary for transcriptional repressionBy similarityAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 238Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the prohibitin family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3090 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000075076
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiQ5XIH7
KOiK17081
OMAiELGTDYD
OrthoDBiEOG091G0IHW
PhylomeDBiQ5XIH7
TreeFamiTF354230

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5XIH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQNLKDLAG RLPSGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI
60 70 80 90 100
FFNRIGGVQQ DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ
110 120 130 140 150
MVNISLRVLS RPNAQELPSM YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA
160 170 180 190 200
SQLITQRAQV SLLIRRELTE RAKDFSLILD DVAITELSFS REYTAAVEAK
210 220 230 240 250
QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE ALSKNPGYIK
260 270 280 290
LRKIRAAQNI SKTIATSQNR IYLTADNLVL NLQDESFTRG SDSLIKGKK
Length:299
Mass (Da):33,312
Last modified:November 23, 2004 - v1
Checksum:iE7699DDD31FCCB69
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2KB63A0A0G2KB63_RAT
Prohibitin-2
Phb2
297Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87P → T in AAB18746 (PubMed:10559001).Curated1
Sequence conflicti108V → F (PubMed:10559001).Curated1
Sequence conflicti287 – 288FT → LI in AAB18747 (PubMed:10559001).Curated2
Sequence conflicti294L → F in AAB18747 (PubMed:10559001).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083705 mRNA Translation: AAH83705.1
U75391 mRNA Translation: AAB18746.1
U75392 mRNA Translation: AAB18747.1
RefSeqiNP_001013053.1, NM_001013035.1
UniGeneiRn.64535

Genome annotation databases

EnsembliENSRNOT00000017472; ENSRNOP00000017472; ENSRNOG00000012999
GeneIDi114766
KEGGirno:114766
UCSCiRGD:620203 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083705 mRNA Translation: AAH83705.1
U75391 mRNA Translation: AAB18746.1
U75392 mRNA Translation: AAB18747.1
RefSeqiNP_001013053.1, NM_001013035.1
UniGeneiRn.64535

3D structure databases

ProteinModelPortaliQ5XIH7
SMRiQ5XIH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250411, 2 interactors
IntActiQ5XIH7, 3 interactors
MINTiQ5XIH7
STRINGi10116.ENSRNOP00000017472

PTM databases

CarbonylDBiQ5XIH7
iPTMnetiQ5XIH7
PhosphoSitePlusiQ5XIH7

Proteomic databases

PaxDbiQ5XIH7
PRIDEiQ5XIH7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017472; ENSRNOP00000017472; ENSRNOG00000012999
GeneIDi114766
KEGGirno:114766
UCSCiRGD:620203 rat

Organism-specific databases

CTDi11331
RGDi620203 Phb2

Phylogenomic databases

eggNOGiKOG3090 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000075076
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiQ5XIH7
KOiK17081
OMAiELGTDYD
OrthoDBiEOG091G0IHW
PhylomeDBiQ5XIH7
TreeFamiTF354230

Enzyme and pathway databases

ReactomeiR-RNO-8949664 Processing of SMDT1

Miscellaneous databases

PROiPR:Q5XIH7

Gene expression databases

BgeeiENSRNOG00000012999 Expressed in 9 organ(s), highest expression level in heart
ExpressionAtlasiQ5XIH7 baseline and differential
GenevisibleiQ5XIH7 RN

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHB2_RAT
AccessioniPrimary (citable) accession number: Q5XIH7
Secondary accession number(s): P70629, P70630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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