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Protein

Spliceosome-associated protein CWC27 homolog

Gene

Cwc27

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.By similarity

Caution

Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Spliceosome-associated protein CWC27 homologCurated
Alternative name(s):
Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homologBy similarity
Short name:
PPIase CWC27By similarity
Gene namesi
Name:Cwc27Imported
Synonyms:Sdccag10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1310697 Cwc27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003136512 – 468Spliceosome-associated protein CWC27 homologAdd BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei273PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5XIB2
PRIDEiQ5XIB2

PTM databases

iPTMnetiQ5XIB2
PhosphoSitePlusiQ5XIB2

Expressioni

Gene expression databases

BgeeiENSRNOG00000013252
ExpressionAtlasiQ5XIB2 baseline and differential
GenevisibleiQ5XIB2 RN

Interactioni

Subunit structurei

Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017832

Structurei

3D structure databases

ProteinModelPortaliQ5XIB2
SMRiQ5XIB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 166PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili206 – 229Sequence analysisAdd BLAST24
Coiled coili309 – 342Sequence analysisAdd BLAST34

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0885 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119072
HOVERGENiHBG097993
InParanoidiQ5XIB2
KOiK12737
OMAiSENHYIN
OrthoDBiEOG091G0BVF
PhylomeDBiQ5XIB2
TreeFamiTF105935

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 2 hits
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XIB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD
60 70 80 90 100
NTIFHRVVPG FIVQGGDPTG TGTGGESVYG APFKDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGPHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLTEVDID
160 170 180 190 200
DEERPRNPHR IKSCEVLFNP FDDIIPREIK KPKKEKAEEE IKKLKPKGTK
210 220 230 240 250
NFSLLSFGEE AEEEEEEVNR VSQSMKGRSK SSHDLLKDDP HLSSVPAVES
260 270 280 290 300
EKDDATGDLE DDAEDDSVEH DGSMEEDEKN LMRERIAKRL KKDASANVKS
310 320 330 340 350
AGDGEKKPAS RSEELRKEAR QLKRELLAAK QKKESATKAE KGSEEEEAVP
360 370 380 390 400
DGPVAEYRRE KQKYEALRKQ QPKKGTSRED QTLALLSQFK SKLTQAITEM
410 420 430 440 450
PENCAEAEVE DDEGWMSHVL QFEDKTRKVK DASMQDSDTF EIYDPRNPVN
460
KRRREESKKL LREKKERR
Length:468
Mass (Da):53,310
Last modified:November 23, 2004 - v1
Checksum:i6F2D09A03E81E725
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083774 mRNA Translation: AAH83774.1
RefSeqiNP_001013217.1, NM_001013199.1
UniGeneiRn.153577

Genome annotation databases

EnsembliENSRNOT00000017832; ENSRNOP00000017832; ENSRNOG00000013252
GeneIDi361887
KEGGirno:361887
UCSCiRGD:1310697 rat

Similar proteinsi

Entry informationi

Entry nameiCWC27_RAT
AccessioniPrimary (citable) accession number: Q5XIB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: June 20, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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