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Protein
Submitted name:

Interferon regulatory factor 3

Gene

Irf3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 111IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST107

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-1169408 ISG15 antiviral mechanism
R-RNO-1606341 IRF3 mediated activation of type 1 IFN
R-RNO-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
R-RNO-3134975 Regulation of innate immune responses to cytosolic DNA
R-RNO-3270619 IRF3-mediated induction of type I IFN
R-RNO-9013973 TICAM1-dependent activation of IRF3/IRF7
R-RNO-918233 TRAF3-dependent IRF activation pathway
R-RNO-933541 TRAF6 mediated IRF7 activation
R-RNO-936440 Negative regulators of DDX58/IFIH1 signaling
R-RNO-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-RNO-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 3Imported
Submitted name:
Interferon regulatory factor 3, isoform CRA_cImported
Gene namesi
Name:Irf3Imported
ORF Names:rCG_54412Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1549774 Irf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000043388

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027786

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 111IRF tryptophan pentad repeatInterPro annotationAdd BLAST107

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IXD8 Eukaryota
ENOG410YA4B LUCA
GeneTreeiENSGT00760000119093
HOGENOMiHOG000033705
HOVERGENiHBG105601
KOiK05411
OMAiCHTYWAV
OrthoDBiEOG091G067P
TreeFamiTF328512

Family and domain databases

CDDicd00103 IRF, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XIB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTPKPLILP WLVSQLDLGQ LKGVAWLDES RTKFRIPWKH GLRQDAQMAD
60 70 80 90 100
FGIFQAWAEA SGAYTPGKDK PDLSTWKRNF RSALNRKEVL RLAEDRSKDP
110 120 130 140 150
FDPHKVYEFV TPGGARDFVH LDTSPDTNGK SSLSDHQEDL LELLDHMALG
160 170 180 190 200
PLPDEGSSDL PIASDPSQPP LSPIVNNFPN PAPQENPLRQ LLAEEQWEFE
210 220 230 240 250
VTAFYRGRQV FQQTLFCPGG LRLVGSTSDN GTLPWQPVTL PDPEEFLTDR
260 270 280 290 300
LVREYVRQVL KGLGKGLVLW RAGQCLWAQR LGHSHSFWAL GEELLPDSGR
310 320 330 340 350
GPDGEVPKDK NGVVFDLRPF VADLIAFMEG SRHSPRYTLW FCVGESWPQD
360 370 380 390 400
QPWVKRLVMV KVVPTCLKEL LEMAREGGAS SLKTVDLHIS NSQPISLTSD
410 420
QYKACLQDLV EDMDFQATGE T
Length:421
Mass (Da):47,279
Last modified:November 23, 2004 - v1
Checksum:i4ECD3290804EF09F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127719 Genomic DNA No translation available.
BC083776 mRNA Translation: AAH83776.1
CH473979 Genomic DNA Translation: EDM07431.1
CH473979 Genomic DNA Translation: EDM07432.1
RefSeqiNP_001006970.1, NM_001006969.1
XP_006229085.1, XM_006229023.2
XP_006229086.1, XM_006229024.2
UniGeneiRn.1499

Genome annotation databases

EnsembliENSRNOT00000027786; ENSRNOP00000027786; ENSRNOG00000043388
GeneIDi292892
KEGGirno:292892

Similar proteinsi

Entry informationi

Entry nameiQ5XIB0_RAT
AccessioniPrimary (citable) accession number: Q5XIB0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: July 18, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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