UniProtKB - Q5XIB0 (Q5XIB0_RAT)
Protein
Submitted name:
Interferon regulatory factor 3
Gene
Irf3
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- identical protein binding Source: RGD
- protein domain specific binding Source: RGD
- protein homodimerization activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- transcription regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- cellular response to exogenous dsRNA Source: RGD
- cellular response to lipopolysaccharide Source: RGD
- defense response to virus Source: RGD
- immune system process Source: GO_Central
- lipopolysaccharide-mediated signaling pathway Source: RGD
- negative regulation of defense response to virus by host Source: RGD
- negative regulation of interferon-beta production Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of cytokine secretion Source: RGD
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
- positive regulation of interferon-alpha production Source: RGD
- positive regulation of interferon-beta production Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of type I interferon-mediated signaling pathway Source: RGD
- positive regulation of type I interferon production Source: RGD
- programmed necrotic cell death Source: RGD
- regulation of gene expression Source: RGD
- regulation of inflammatory response Source: RGD
- response to bacterium Source: RGD
- response to exogenous dsRNA Source: RGD
- response to lipopolysaccharide Source: RGD
- TRIF-dependent toll-like receptor signaling pathway Source: RGD
- type I interferon production Source: RGD
- type I interferon signaling pathway Source: RGD
Keywordsi
Biological process | Transcription, Transcription regulationARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-1169408, ISG15 antiviral mechanism R-RNO-1606341, IRF3 mediated activation of type 1 IFN R-RNO-3134973, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-RNO-3134975, Regulation of innate immune responses to cytosolic DNA R-RNO-3270619, IRF3-mediated induction of type I IFN R-RNO-9013973, TICAM1-dependent activation of IRF3/IRF7 R-RNO-918233, TRAF3-dependent IRF activation pathway R-RNO-933541, TRAF6 mediated IRF7 activation R-RNO-936440, Negative regulators of DDX58/IFIH1 signaling R-RNO-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
Names & Taxonomyi
Protein namesi | Submitted name: Interferon regulatory factor 3ImportedSubmitted name: Interferon regulatory factor 3, isoform CRA_cImported |
Gene namesi | Name:Irf3Imported ORF Names:rCG_54412Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1549774, Irf3 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000043388, Expressed in brain and 22 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
- protein domain specific binding Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027786 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 111 | IRF tryptophan pentad repeatInterPro annotationAdd BLAST | 107 |
Phylogenomic databases
eggNOGi | ENOG502QTRR, Eukaryota |
GeneTreei | ENSGT00940000160569 |
HOGENOMi | CLU_031544_2_0_1 |
OMAi | QTVFCPR |
OrthoDBi | 648909at2759 |
TreeFami | TF328512 |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5XIB0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTPKPLILP WLVSQLDLGQ LKGVAWLDES RTKFRIPWKH GLRQDAQMAD
60 70 80 90 100
FGIFQAWAEA SGAYTPGKDK PDLSTWKRNF RSALNRKEVL RLAEDRSKDP
110 120 130 140 150
FDPHKVYEFV TPGGARDFVH LDTSPDTNGK SSLSDHQEDL LELLDHMALG
160 170 180 190 200
PLPDEGSSDL PIASDPSQPP LSPIVNNFPN PAPQENPLRQ LLAEEQWEFE
210 220 230 240 250
VTAFYRGRQV FQQTLFCPGG LRLVGSTSDN GTLPWQPVTL PDPEEFLTDR
260 270 280 290 300
LVREYVRQVL KGLGKGLVLW RAGQCLWAQR LGHSHSFWAL GEELLPDSGR
310 320 330 340 350
GPDGEVPKDK NGVVFDLRPF VADLIAFMEG SRHSPRYTLW FCVGESWPQD
360 370 380 390 400
QPWVKRLVMV KVVPTCLKEL LEMAREGGAS SLKTVDLHIS NSQPISLTSD
410 420
QYKACLQDLV EDMDFQATGE T
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC127719 Genomic DNA No translation available. BC083776 mRNA Translation: AAH83776.1 CH473979 Genomic DNA Translation: EDM07431.1 CH473979 Genomic DNA Translation: EDM07432.1 |
RefSeqi | NP_001006970.1, NM_001006969.1 XP_006229085.1, XM_006229023.2 XP_006229086.1, XM_006229024.2 |
Genome annotation databases
Ensembli | ENSRNOT00000027786; ENSRNOP00000027786; ENSRNOG00000043388 |
GeneIDi | 292892 |
KEGGi | rno:292892 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC127719 Genomic DNA No translation available. BC083776 mRNA Translation: AAH83776.1 CH473979 Genomic DNA Translation: EDM07431.1 CH473979 Genomic DNA Translation: EDM07432.1 |
RefSeqi | NP_001006970.1, NM_001006969.1 XP_006229085.1, XM_006229023.2 XP_006229086.1, XM_006229024.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027786 |
Genome annotation databases
Ensembli | ENSRNOT00000027786; ENSRNOP00000027786; ENSRNOG00000043388 |
GeneIDi | 292892 |
KEGGi | rno:292892 |
Organism-specific databases
CTDi | 3661 |
RGDi | 1549774, Irf3 |
Phylogenomic databases
eggNOGi | ENOG502QTRR, Eukaryota |
GeneTreei | ENSGT00940000160569 |
HOGENOMi | CLU_031544_2_0_1 |
OMAi | QTVFCPR |
OrthoDBi | 648909at2759 |
TreeFami | TF328512 |
Enzyme and pathway databases
Reactomei | R-RNO-1169408, ISG15 antiviral mechanism R-RNO-1606341, IRF3 mediated activation of type 1 IFN R-RNO-3134973, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-RNO-3134975, Regulation of innate immune responses to cytosolic DNA R-RNO-3270619, IRF3-mediated induction of type I IFN R-RNO-9013973, TICAM1-dependent activation of IRF3/IRF7 R-RNO-918233, TRAF3-dependent IRF activation pathway R-RNO-933541, TRAF6 mediated IRF7 activation R-RNO-936440, Negative regulators of DDX58/IFIH1 signaling R-RNO-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
Gene expression databases
Bgeei | ENSRNOG00000043388, Expressed in brain and 22 other tissues |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR019817, Interferon_reg_fac_CS IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 1 hit |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
PRINTSi | PR00267, INTFRNREGFCT |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS00601, IRF_1, 1 hit PS51507, IRF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5XIB0_RAT | |
Accessioni | Q5XIB0Primary (citable) accession number: Q5XIB0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 23, 2004 |
Last sequence update: | November 23, 2004 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |