Interferon regulatory factor 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
• identical protein binding Source: RGD
• protein domain specific binding Source: RGD
• protein homodimerization activity Source: RGD
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
• sequence-specific DNA binding Source: RGD
• sequence-specific double-stranded DNA binding Source: RGD
• transcription regulatory region sequence-specific DNA binding Source: RGD

GO - Biological processⁱ

• cellular response to exogenous dsRNA Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways."
    Dogusan Z., Garcia M., Flamez D., Alexopoulou L., Goldman M., Gysemans C., Mathieu C., Libert C., Eizirik D.L., Rasschaert J.
    Diabetes 57:1236-1245(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: RGD
• defense response to virus Source: RGD
• immune system process Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• lipopolysaccharide-mediated signaling pathway Source: RGD
• negative regulation of defense response to virus by host Source: RGD
• negative regulation of interferon-beta production Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of cytokine secretion Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "C-reactive protein triggers inflammatory responses partly via TLR4/IRF3/NF-kappaB signaling pathway in rat vascular smooth muscle cells."
    Liu N., Liu J.T., Ji Y.Y., Lu P.P.
    Life Sci 87:367-374(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGDInferred from mutant phenotypeⁱ
  • "C-reactive protein triggers inflammatory responses partly via TLR4/IRF3/NF-kappaB signaling pathway in rat vascular smooth muscle cells."
    Liu N., Liu J.T., Ji Y.Y., Lu P.P.
    Life Sci 87:367-374(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interferon-alpha production Source: RGD
• positive regulation of interferon-beta production Source: RGD
• positive regulation of transcription, DNA-templated Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• positive regulation of type I interferon-mediated signaling pathway Source: RGD
• positive regulation of type I interferon production Source: RGD
• programmed necrotic cell death Source: RGD
• regulation of gene expression Source: RGD
• regulation of inflammatory response Source: RGD
• response to bacterium Source: RGD
• response to exogenous dsRNA Source: RGD
• response to lipopolysaccharide Source: RGD
• TRIF-dependent toll-like receptor signaling pathway Source: RGD
• type I interferon production Source: RGD
• type I interferon signaling pathway Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGD
• protein domain specific binding Source: RGD
• protein homodimerization activity Source: RGD

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGTPKPLILP WLVSQLDLGQ LKGVAWLDES RTKFRIPWKH GLRQDAQMAD 
        60         70         80         90        100
FGIFQAWAEA SGAYTPGKDK PDLSTWKRNF RSALNRKEVL RLAEDRSKDP 
       110        120        130        140        150
FDPHKVYEFV TPGGARDFVH LDTSPDTNGK SSLSDHQEDL LELLDHMALG 
       160        170        180        190        200
PLPDEGSSDL PIASDPSQPP LSPIVNNFPN PAPQENPLRQ LLAEEQWEFE 
       210        220        230        240        250
VTAFYRGRQV FQQTLFCPGG LRLVGSTSDN GTLPWQPVTL PDPEEFLTDR 
       260        270        280        290        300
LVREYVRQVL KGLGKGLVLW RAGQCLWAQR LGHSHSFWAL GEELLPDSGR 
       310        320        330        340        350
GPDGEVPKDK NGVVFDLRPF VADLIAFMEG SRHSPRYTLW FCVGESWPQD 
       360        370        380        390        400
QPWVKRLVMV KVVPTCLKEL LEMAREGGAS SLKTVDLHIS NSQPISLTSD 
       410        420 
QYKACLQDLV EDMDFQATGE T                                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ