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UniProtKB - Q5XIA8 (GHITM_RAT)
Protein
Growth hormone-inducible transmembrane protein
Gene
Ghitm
Organism
Rattus norvegicus (Rat)
Status
Functioni
Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity).
By similarityGO - Biological processi
- apoptotic process Source: UniProtKB-KW
- inner mitochondrial membrane organization Source: RGD
- negative regulation of release of cytochrome c from mitochondria Source: RGD
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Growth hormone-inducible transmembrane proteinAlternative name(s): Mitochondrial morphology and cristae structure 1 Short name: MICS1 |
Gene namesi | Name:Ghitm Synonyms:Mics1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359301, Ghitm |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
Other locations
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 46 – 83 | Mitochondrial matrixSequence analysisAdd BLAST | 38 | |
Transmembranei | 84 – 104 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 105 – 126 | Mitochondrial intermembraneSequence analysisAdd BLAST | 22 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 148 – 160 | Mitochondrial matrixSequence analysisAdd BLAST | 13 | |
Transmembranei | 161 – 181 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 182 – 191 | Mitochondrial intermembraneSequence analysis | 10 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 214 | Mitochondrial matrixSequence analysis | 2 | |
Transmembranei | 215 – 235 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 236 – 245 | Mitochondrial intermembraneSequence analysis | 10 | |
Transmembranei | 246 – 266 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 267 – 272 | Mitochondrial matrixSequence analysis | 6 | |
Transmembranei | 273 – 293 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 294 – 346 | Mitochondrial intermembraneSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 45 | MitochondrionCuratedAdd BLAST | 45 | |
ChainiPRO_0000402543 | 46 – 346 | Growth hormone-inducible transmembrane proteinAdd BLAST | 301 |
Proteomic databases
PaxDbi | Q5XIA8 |
PRIDEi | Q5XIA8 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000013961, Expressed in heart and 20 other tissues |
Genevisiblei | Q5XIA8, RN |
Structurei
3D structure databases
AlphaFoldDBi | Q5XIA8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the BI1 family.Curated
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1630, Eukaryota |
GeneTreei | ENSGT01030000234603 |
HOGENOMi | CLU_050797_1_0_1 |
InParanoidi | Q5XIA8 |
OMAi | MYGTFYT |
OrthoDBi | 1228054at2759 |
PhylomeDBi | Q5XIA8 |
TreeFami | TF314017 |
Family and domain databases
CDDi | cd10431, GHITM, 1 hit |
InterProi | View protein in InterPro IPR006214, Bax_inhibitor_1-related IPR035871, GHITM |
PANTHERi | PTHR23291, PTHR23291, 1 hit |
Pfami | View protein in Pfam PF01027, Bax1-I, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5XIA8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAARLVCLR TLPSRVFQPT FITKASPLVK NSITKNQWLL TPSREYATKT
60 70 80 90 100
RIRTHRGKTG QELKEAALEP SLEKVFKIDQ MGKWFVAGGA AVGLGALCYY
110 120 130 140 150
GLGMSNEIGA IEKAVIWPQY VKDRIHSTYM YLAGSIGLTA LSALALARSP
160 170 180 190 200
ALMNFMMTGS WMTIGATFAA MIGAGMLVQS ISYEQSPGPK HLAWMLHSGV
210 220 230 240 250
MGAVVAPLTI LGGPLLLRAA WYTAGIVGGL STVAMCAPSE KFLNMGAPLG
260 270 280 290 300
VGLGLVFASS LGSMFLPPTS VAGATLYSVA MYGGLVLFSM FLLYDTQKVV
310 320 330 340
KRAEITPAYG AQKYDPINSM LTIYMDTLNI FMRVATMLAT GSNRKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083778 mRNA Translation: AAH83778.1 |
RefSeqi | NP_001005908.1, NM_001005908.1 XP_006252848.1, XM_006252786.2 |
Genome annotation databases
Ensembli | ENSRNOT00000106368; ENSRNOP00000077387; ENSRNOG00000013961 |
GeneIDi | 290596 |
KEGGi | rno:290596 |
UCSCi | RGD:1359301, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083778 mRNA Translation: AAH83778.1 |
RefSeqi | NP_001005908.1, NM_001005908.1 XP_006252848.1, XM_006252786.2 |
3D structure databases
AlphaFoldDBi | Q5XIA8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000018723 |
Proteomic databases
PaxDbi | Q5XIA8 |
PRIDEi | Q5XIA8 |
Genome annotation databases
Ensembli | ENSRNOT00000106368; ENSRNOP00000077387; ENSRNOG00000013961 |
GeneIDi | 290596 |
KEGGi | rno:290596 |
UCSCi | RGD:1359301, rat |
Organism-specific databases
CTDi | 27069 |
RGDi | 1359301, Ghitm |
Phylogenomic databases
eggNOGi | KOG1630, Eukaryota |
GeneTreei | ENSGT01030000234603 |
HOGENOMi | CLU_050797_1_0_1 |
InParanoidi | Q5XIA8 |
OMAi | MYGTFYT |
OrthoDBi | 1228054at2759 |
PhylomeDBi | Q5XIA8 |
TreeFami | TF314017 |
Miscellaneous databases
PROi | PR:Q5XIA8 |
Gene expression databases
Bgeei | ENSRNOG00000013961, Expressed in heart and 20 other tissues |
Genevisiblei | Q5XIA8, RN |
Family and domain databases
CDDi | cd10431, GHITM, 1 hit |
InterProi | View protein in InterPro IPR006214, Bax_inhibitor_1-related IPR035871, GHITM |
PANTHERi | PTHR23291, PTHR23291, 1 hit |
Pfami | View protein in Pfam PF01027, Bax1-I, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GHITM_RAT | |
Accessioni | Q5XIA8Primary (citable) accession number: Q5XIA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | November 23, 2004 | |
Last modified: | May 25, 2022 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families