UniProtKB - Q5XIA0 (DZI1L_RAT)
Protein
Zinc finger protein DZIP1L
Gene
Dzip1l
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 166 – 189 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- ciliary transition zone assembly Source: RGD
- cilium assembly Source: UniProtKB
- floor plate development Source: RGD
- neural tube patterning Source: RGD
- protein localization to cilium Source: RGD
- protein localization to organelle Source: RGD
- regulation of protein localization Source: UniProtKB
- smoothened signaling pathway Source: RGD
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein DZIP1LAlternative name(s): DAZ-interacting protein 1-like protein |
Gene namesi | Name:Dzip1l |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1311430, Dzip1l |
Subcellular locationi
Cytoskeleton
- cilium basal body By similarity
- centriole By similarity
Note: Localizes to centrioles and to the distal ends of basal bodies.By similarity
Cytoskeleton
- axoneme Source: RGD
- centriole Source: UniProtKB
- ciliary basal body Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331308 | 1 – 776 | Zinc finger protein DZIP1LAdd BLAST | 776 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 425 | PhosphoserineBy similarity | 1 | |
Modified residuei | 426 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q5XIA0 |
PaxDbi | Q5XIA0 |
PRIDEi | Q5XIA0 |
PTM databases
iPTMneti | Q5XIA0 |
PhosphoSitePlusi | Q5XIA0 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000014746, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | Q5XIA0, RN |
Interactioni
Subunit structurei
Interacts with SEPTIN2.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019902 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 196 – 450 | Sequence analysisAdd BLAST | 255 |
Sequence similaritiesi
Belongs to the DZIP C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 166 – 189 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QRAI, Eukaryota |
GeneTreei | ENSGT00940000160898 |
InParanoidi | Q5XIA0 |
OMAi | HIGRKHR |
OrthoDBi | 1162102at2759 |
PhylomeDBi | Q5XIA0 |
Family and domain databases
InterProi | View protein in InterPro IPR032714, DZIP1_N IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13815, Dzip-like_N, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5XIA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQYSVATADG LSGPPSGAYT LPTFKFQPRR ESIDWRRISA VDVDRVAREL
60 70 80 90 100
DVATLQENIA GVTFCNLDRE VCNHCRQPVD PVLLKVLRLA QLIIEYLLHC
110 120 130 140 150
QDCLSASVAQ LEARLQASLG QQQRGQQELG RQADELKGVR EESRRRRKMI
160 170 180 190 200
STLQQLLLQT GAHSYHTCHL CDKTFMNATF LRGHIQRRHA GMAEVGKQKQ
210 220 230 240 250
EQQLGEVLEE LRAKLKWTQG ELEAQREAER QRQAQELEMI RQREIEAKKK
260 270 280 290 300
FDEWKEKERS KLYGEIDKLK QLFWDEFKTV ANQNSTLEEK LKVLQSYSMT
310 320 330 340 350
ESHLGSLRDE ESEERLKHAQ ELQALREKMD IQKTEWKRKM KALHEERAAE
360 370 380 390 400
RRQLQEENER LHVTLSQDQK KAAAQSQRHI NALRAQLQEQ ARLIESQEET
410 420 430 440 450
IQTLSFRRME EVQEVPKAVV TEEDSSEEEL EASLEEQQEQ RKVLAALRNN
460 470 480 490 500
PAWLKQFRPI LEDTLEEKLE GMGIKRGTKG ISAQTVRRLE PLLRTQREQT
510 520 530 540 550
ARSFREFLSL REKLNQEVSS RAKKRWEGTA VVPQPDGQPP VKSQRTTLAT
560 570 580 590 600
REVRPKTRTL TVALPSKPAE PSTSTPRGHS SHGPGLTQVS TPIPRPRVHG
610 620 630 640 650
PSSTPVSPGP GLSTPPFSSE EEPEGDVVQR VSLQPPKVLP RSAPQPEDNW
660 670 680 690 700
GWSDSETSEE SAQSPGKGSD GLASSATLVQ SMVKNLEKQL ETPAKKPSGG
710 720 730 740 750
VNMFLRPNTA LQRSSTPARK TQLSEDESDL EISSLEDLSH DLGPKGKPTP
760 770
LSHSKLPEKF DASPWSSGSR PRIPGW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083786 mRNA Translation: AAH83786.1 |
RefSeqi | NP_001014117.1, NM_001014095.1 |
Genome annotation databases
Ensembli | ENSRNOT00000019902; ENSRNOP00000019902; ENSRNOG00000014746 ENSRNOT00000090299; ENSRNOP00000074346; ENSRNOG00000014746 |
GeneIDi | 315952 |
KEGGi | rno:315952 |
UCSCi | RGD:1311430, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083786 mRNA Translation: AAH83786.1 |
RefSeqi | NP_001014117.1, NM_001014095.1 |
3D structure databases
SMRi | Q5XIA0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000019902 |
PTM databases
iPTMneti | Q5XIA0 |
PhosphoSitePlusi | Q5XIA0 |
Proteomic databases
jPOSTi | Q5XIA0 |
PaxDbi | Q5XIA0 |
PRIDEi | Q5XIA0 |
Genome annotation databases
Ensembli | ENSRNOT00000019902; ENSRNOP00000019902; ENSRNOG00000014746 ENSRNOT00000090299; ENSRNOP00000074346; ENSRNOG00000014746 |
GeneIDi | 315952 |
KEGGi | rno:315952 |
UCSCi | RGD:1311430, rat |
Organism-specific databases
CTDi | 199221 |
RGDi | 1311430, Dzip1l |
Phylogenomic databases
eggNOGi | ENOG502QRAI, Eukaryota |
GeneTreei | ENSGT00940000160898 |
InParanoidi | Q5XIA0 |
OMAi | HIGRKHR |
OrthoDBi | 1162102at2759 |
PhylomeDBi | Q5XIA0 |
Miscellaneous databases
PROi | PR:Q5XIA0 |
Gene expression databases
Bgeei | ENSRNOG00000014746, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | Q5XIA0, RN |
Family and domain databases
InterProi | View protein in InterPro IPR032714, DZIP1_N IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13815, Dzip-like_N, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DZI1L_RAT | |
Accessioni | Q5XIA0Primary (citable) accession number: Q5XIA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | November 23, 2004 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families