UniProtKB - Q5XI59 (RNF10_RAT)
Protein
RING finger protein 10
Gene
Rnf10
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 225 – 267 | RING-typePROSITE-ProRule annotationAdd BLAST | 43 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
- ubiquitin protein ligase activity Source: RGD
GO - Biological processi
- negative regulation of Schwann cell proliferation Source: UniProtKB
- positive regulation of myelination Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- postsynapse to nucleus signaling pathway Source: SynGO
- protein autoubiquitination Source: RGD
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger protein 10 |
Gene namesi | Name:Rnf10 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309282, Rnf10 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- extrinsic component of postsynaptic density membrane Source: SynGO
Other locations
- cytoplasm Source: RGD
- glutamatergic synapse Source: SynGO
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259587 | 1 – 802 | RING finger protein 10Add BLAST | 802 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 5 | PhosphoserineBy similarity | 1 | |
Modified residuei | 110 | PhosphoserineBy similarity | 1 | |
Modified residuei | 128 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q5XI59 |
PRIDEi | Q5XI59 |
Interactioni
Subunit structurei
Interacts with MEOX2.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000063855 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 4 – 111 | Ser-richAdd BLAST | 108 |
Sequence similaritiesi
Belongs to the RNF10 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 225 – 267 | RING-typePROSITE-ProRule annotationAdd BLAST | 43 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2164, Eukaryota |
HOGENOMi | CLU_018206_0_0_1 |
InParanoidi | Q5XI59 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR039739, Mag2/Rnf10 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR12983, PTHR12983, 1 hit |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5XI59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPQSSPSTAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP
60 70 80 90 100
KSDGKNSNGS KRYNRKREPS YPKNENFSNQ SRRSNSQKSK TFNKTPPQRG
110 120 130 140 150
GGSSKPFSSS SNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP
160 170 180 190 200
RGQAGHFEGS GHGSWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYTANF
210 220 230 240 250
ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL
260 270 280 290 300
HYLSLSERTW SKCPICYSSV HKKDLKSVVA TESRQYVVGD TITMQLMKRE
310 320 330 340 350
KGVLVALPKS KWMNVDHPIS LGDEQHSQYS KLLLASKEQV LHRVVLEEKV
360 370 380 390 400
ALEQQLAEEK HTPESCFIEA ALQEVKIREE ALSGVAGGRA EVTGVVTALE
410 420 430 440 450
QLVLMAPLAK ESAFQPRKGV LEYLSAFDEE AAQVCSLDPP GPLALPLVEE
460 470 480 490 500
EEAVSEPEAC EDLIADDSLG EGTVCAELSQ EEPIAKPGFT QLSSSPCYYF
510 520 530 540 550
YQAEDGQHMF LHPVNVRCLV REYGSLEQSP EKISATVVEI AGYSMSEDVR
560 570 580 590 600
QRHRYLSHLP LTCEFSICEL ALQPPVVSKE TLEMFSDDIE KRKRQRQKKA
610 620 630 640 650
REERRRERRI ELEENKRQGR YPEVHIPLEN LQQFPAFNSY TCSSDSALGP
660 670 680 690 700
TSTEGHGALS LSPLSRSPGS HADFLLTPLS PTASQGSPSF CVGSLEEDSP
710 720 730 740 750
FLSFAQMLRV GKAKADGWPK AAPKKDDNSL APPAPVDSDG ESDNSDRVPV
760 770 780 790 800
PSFQNSFSQA IEAAFMKLDT PATSDPLSDR GGRKRKRQKQ KLLFSTSVVH
TK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0H2UI24 | A0A0H2UI24_RAT | RING finger protein 10 | Rnf10 | 803 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083831 mRNA Translation: AAH83831.1 |
RefSeqi | NP_001011904.1, NM_001011904.1 |
Genome annotation databases
GeneIDi | 288710 |
KEGGi | rno:288710 |
UCSCi | RGD:1309282, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083831 mRNA Translation: AAH83831.1 |
RefSeqi | NP_001011904.1, NM_001011904.1 |
3D structure databases
SMRi | Q5XI59 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000063855 |
Proteomic databases
PaxDbi | Q5XI59 |
PRIDEi | Q5XI59 |
Genome annotation databases
GeneIDi | 288710 |
KEGGi | rno:288710 |
UCSCi | RGD:1309282, rat |
Organism-specific databases
CTDi | 9921 |
RGDi | 1309282, Rnf10 |
Phylogenomic databases
eggNOGi | KOG2164, Eukaryota |
HOGENOMi | CLU_018206_0_0_1 |
InParanoidi | Q5XI59 |
Miscellaneous databases
PROi | PR:Q5XI59 |
Gene expression databases
Genevisiblei | Q5XI59, RN |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR039739, Mag2/Rnf10 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR12983, PTHR12983, 1 hit |
Pfami | View protein in Pfam PF13639, zf-RING_2, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RNF10_RAT | |
Accessioni | Q5XI59Primary (citable) accession number: Q5XI59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | November 23, 2004 | |
Last modified: | August 12, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families