UniProtKB - Q5XI42 (AL3B1_RAT)
Protein
Aldehyde dehydrogenase family 3 member B1
Gene
Aldh3b1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP+ and NAD+ as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation.By similarity
Catalytic activityi
: ethanol degradation Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Aldehyde dehydrogenase, mitochondrial (Aldh2), Aldehyde dehydrogenase X, mitochondrial (Aldh1b1), Aldehyde dehydrogenase, cytosolic 1 (Aldh1a7), Aldehyde dehydrogenase family 3 member B1 (Aldh3b1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 210 | By similarity | 1 | |
Active sitei | 244 | By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 188 – 193 | NADBy similarity | 6 |
GO - Molecular functioni
- 3-chloroallyl aldehyde dehydrogenase activity Source: GO_Central
- aldehyde dehydrogenase (NAD+) activity Source: RGD
- aldehyde dehydrogenase [NAD(P)+] activity Source: RGD
- benzaldehyde dehydrogenase (NAD+) activity Source: UniProtKB-EC
- benzaldehyde dehydrogenase (NADP+) activity Source: UniProtKB-EC
GO - Biological processi
- aldehyde catabolic process Source: RGD
- cellular response to oxidative stress Source: RGD
- ethanol catabolic process Source: UniProtKB-UniPathway
- oxidation-reduction process Source: RGD
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-RNO-1660661, Sphingolipid de novo biosynthesis R-RNO-6798695, Neutrophil degranulation |
UniPathwayi | UPA00780;UER00768 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Aldh3b1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359546, Aldh3b1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity
Note: Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.By similarity
Cytosol
- cytosol Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056483 | 1 – 465 | Aldehyde dehydrogenase family 3 member B1Add BLAST | 465 | |
PropeptideiPRO_0000424195 | 466 – 468 | Removed in mature formCurated | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Lipidationi | 462 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 463 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 465 | Cysteine methyl esterCurated | 1 | |
Lipidationi | 465 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.By similarity
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, Palmitate, PrenylationProteomic databases
PaxDbi | Q5XI42 |
PRIDEi | Q5XI42 |
PTM databases
PhosphoSitePlusi | Q5XI42 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000017512, Expressed in brain and 21 other tissues |
ExpressionAtlasi | Q5XI42, baseline and differential |
Genevisiblei | Q5XI42, RN |
Interactioni
Protein-protein interaction databases
BioGRIDi | 259282, 1 interactor |
STRINGi | 10116.ENSRNOP00000023789 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG2456, Eukaryota |
GeneTreei | ENSGT00940000162915 |
HOGENOMi | CLU_005391_3_1_1 |
InParanoidi | Q5XI42 |
OrthoDBi | 646662at2759 |
PhylomeDBi | Q5XI42 |
TreeFami | TF314264 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR012394, Aldehyde_DH_NAD(P) |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
PIRSFi | PIRSF036492, ALDH, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5XI42-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSFEDKLQQ LREAFNAGRT RSAEFRAAQL QGLSHFLRDN KQQLQEALAQ
60 70 80 90 100
DLHKSAFESE VSEIAISQAE VDLALRNLRS WMKDEKVSKN LATQLDSAFI
110 120 130 140 150
RKEPFGLVLI IVPWNYPLNL TLVPLVGAIA AGNCVVLKPS EISKATEKIL
160 170 180 190 200
AEVLPRYLDQ SCFAVVLGGP QETGQLLEHR FDYIFFTGNT YVGKIVMAAA
210 220 230 240 250
AKHLTPITLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA GQTCVAPDYV
260 270 280 290 300
LCSQEMQERL VPALQNAITR FYGDNPQTSP NLGRIINQKH FERLQGLLGC
310 320 330 340 350
GRVAIGGQSD EGERYIAPTV LVDVQETEPV MQEEIFGPIL PLVTVTNLDE
360 370 380 390 400
AIEFINRREK PLALYAFSKR SQVIKQVLAR TSSGGFCGND GFMHMTLSSL
410 420 430 440 450
PFGGVGTSGM GRYHGKFSFD TFSNQRACLL RSPGMEKIND LRYPPYTSRN
460
LRVLLVAMEK RCCSCTLL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K7W2 | A0A0G2K7W2_RAT | Aldehyde dehydrogenase | Aldh3b1 | 521 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083850 mRNA Translation: AAH83850.1 |
RefSeqi | NP_001006999.1, NM_001006998.1 XP_006230849.1, XM_006230787.3 XP_008758356.1, XM_008760134.1 |
Genome annotation databases
Ensembli | ENSRNOT00000023789; ENSRNOP00000023789; ENSRNOG00000017512 |
GeneIDi | 309147 |
KEGGi | rno:309147 |
UCSCi | RGD:1359546, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC083850 mRNA Translation: AAH83850.1 |
RefSeqi | NP_001006999.1, NM_001006998.1 XP_006230849.1, XM_006230787.3 XP_008758356.1, XM_008760134.1 |
3D structure databases
SMRi | Q5XI42 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 259282, 1 interactor |
STRINGi | 10116.ENSRNOP00000023789 |
PTM databases
PhosphoSitePlusi | Q5XI42 |
Proteomic databases
PaxDbi | Q5XI42 |
PRIDEi | Q5XI42 |
Genome annotation databases
Ensembli | ENSRNOT00000023789; ENSRNOP00000023789; ENSRNOG00000017512 |
GeneIDi | 309147 |
KEGGi | rno:309147 |
UCSCi | RGD:1359546, rat |
Organism-specific databases
CTDi | 221 |
RGDi | 1359546, Aldh3b1 |
Phylogenomic databases
eggNOGi | KOG2456, Eukaryota |
GeneTreei | ENSGT00940000162915 |
HOGENOMi | CLU_005391_3_1_1 |
InParanoidi | Q5XI42 |
OrthoDBi | 646662at2759 |
PhylomeDBi | Q5XI42 |
TreeFami | TF314264 |
Enzyme and pathway databases
UniPathwayi | UPA00780;UER00768 |
Reactomei | R-RNO-1660661, Sphingolipid de novo biosynthesis R-RNO-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:Q5XI42 |
Gene expression databases
Bgeei | ENSRNOG00000017512, Expressed in brain and 21 other tissues |
ExpressionAtlasi | Q5XI42, baseline and differential |
Genevisiblei | Q5XI42, RN |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR012394, Aldehyde_DH_NAD(P) |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
PIRSFi | PIRSF036492, ALDH, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AL3B1_RAT | |
Accessioni | Q5XI42Primary (citable) accession number: Q5XI42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | November 23, 2004 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families