Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (07 Apr 2021)
Sequence version 1 (23 Nov 2004)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a

Gene

Ppp2r1a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-RNO-1295596, Spry regulation of FGF signaling
R-RNO-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-RNO-180024, DARPP-32 events
R-RNO-195253, Degradation of beta-catenin by the destruction complex
R-RNO-196299, Beta-catenin phosphorylation cascade
R-RNO-198753, ERK/MAPK targets
R-RNO-202670, ERKs are inactivated
R-RNO-2467813, Separation of Sister Chromatids
R-RNO-2500257, Resolution of Sister Chromatid Cohesion
R-RNO-2565942, Regulation of PLK1 Activity at G2/M Transition
R-RNO-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-RNO-380259, Loss of Nlp from mitotic centrosomes
R-RNO-380270, Recruitment of mitotic centrosome proteins and complexes
R-RNO-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-RNO-380320, Recruitment of NuMA to mitotic centrosomes
R-RNO-389513, CTLA4 inhibitory signaling
R-RNO-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-RNO-5620912, Anchoring of the basal body to the plasma membrane
R-RNO-5663220, RHO GTPases Activate Formins
R-RNO-5673000, RAF activation
R-RNO-5675221, Negative regulation of MAPK pathway
R-RNO-6804757, Regulation of TP53 Degradation
R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-68877, Mitotic Prometaphase
R-RNO-69231, Cyclin D associated events in G1
R-RNO-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-RNO-8854518, AURKA Activation by TPX2
R-RNO-9648025, EML4 and NUDC in mitotic spindle formation
R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_aImported
Submitted name:
Protein phosphatase 2 (Formerly 2A), regulatory subunit A, alpha isoformImported
Submitted name:
Protein phosphatase 2 scaffold subunit A alphaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ppp2r1aImported
ORF Names:rCG_22961Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
620907, Ppp2r1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5XI34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000011282, Expressed in brain and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000015019

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5XI34

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati12 – 50HEATPROSITE-ProRule annotationAdd BLAST39
Repeati89 – 127HEATPROSITE-ProRule annotationAdd BLAST39
Repeati166 – 204HEATPROSITE-ProRule annotationAdd BLAST39
Repeati205 – 243HEATPROSITE-ProRule annotationAdd BLAST39
Repeati244 – 282HEATPROSITE-ProRule annotationAdd BLAST39
Repeati283 – 320HEATPROSITE-ProRule annotationAdd BLAST38
Repeati326 – 364HEATPROSITE-ProRule annotationAdd BLAST39
Repeati365 – 403HEATPROSITE-ProRule annotationAdd BLAST39
Repeati404 – 442HEATPROSITE-ProRule annotationAdd BLAST39
Repeati521 – 559HEATPROSITE-ProRule annotationAdd BLAST39
Repeati560 – 589HEATPROSITE-ProRule annotationAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0211, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183066

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015533_2_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VKFFATR

Database of Orthologous Groups

More...
OrthoDBi
447572at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105552

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR021133, HEAT_type_2
IPR031090, PP2A_A_meta

The PANTHER Classification System

More...
PANTHERi
PTHR10648:SF2, PTHR10648:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02985, HEAT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077, HEAT_REPEAT, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5XI34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE
60 70 80 90 100
LLPFLTDTIY DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE
110 120 130 140 150
ETVVRDKAVE SLRAISHEHS PSDLEAHFVP LVKRLAGGDW FTSRTSACGL
160 170 180 190 200
FSVCYPRVSS AVKAELRQYF RNLCSDDTPM VRRAAASKLG EFAKVLELDN
210 220 230 240 250
VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL EALVMPTLRQ
260 270 280 290 300
AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA
310 320 330 340 350
AASHKVKEFC ENLSADCREN VIMTQILPCI KELVSDANQH VKSALASVIM
360 370 380 390 400
GLSPILGKDN TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL
410 420 430 440 450
SQSLLPAIVE LAEDAKWRVR LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW
460 470 480 490 500
LVDHVYAIRE AATSNLKKLV EKFGKEWAHA TIIPKVLAMS GDPNYLHRMT
510 520 530 540 550
TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV AKSLQKIGPI
560 570 580
LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA
Length:589
Mass (Da):65,323
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5175409E4D50A366
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07001873 Genomic DNA No translation available.
BC083859 mRNA Translation: AAH83859.1
CH474033 Genomic DNA Translation: EDL99781.1

NCBI Reference Sequences

More...
RefSeqi
NP_476481.1, NM_057140.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000015019; ENSRNOP00000015019; ENSRNOG00000011282

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
117281

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:117281

UCSC genome browser

More...
UCSCi
RGD:620907, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07001873 Genomic DNA No translation available.
BC083859 mRNA Translation: AAH83859.1
CH474033 Genomic DNA Translation: EDL99781.1
RefSeqiNP_476481.1, NM_057140.1

3D structure databases

SMRiQ5XI34
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015019

Proteomic databases

PRIDEiQ5XI34

Genome annotation databases

EnsembliENSRNOT00000015019; ENSRNOP00000015019; ENSRNOG00000011282
GeneIDi117281
KEGGirno:117281
UCSCiRGD:620907, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5518
RGDi620907, Ppp2r1a

Phylogenomic databases

eggNOGiKOG0211, Eukaryota
GeneTreeiENSGT00950000183066
HOGENOMiCLU_015533_2_1_1
OMAiVKFFATR
OrthoDBi447572at2759
TreeFamiTF105552

Enzyme and pathway databases

ReactomeiR-RNO-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-RNO-1295596, Spry regulation of FGF signaling
R-RNO-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-RNO-180024, DARPP-32 events
R-RNO-195253, Degradation of beta-catenin by the destruction complex
R-RNO-196299, Beta-catenin phosphorylation cascade
R-RNO-198753, ERK/MAPK targets
R-RNO-202670, ERKs are inactivated
R-RNO-2467813, Separation of Sister Chromatids
R-RNO-2500257, Resolution of Sister Chromatid Cohesion
R-RNO-2565942, Regulation of PLK1 Activity at G2/M Transition
R-RNO-2995383, Initiation of Nuclear Envelope (NE) Reformation
R-RNO-380259, Loss of Nlp from mitotic centrosomes
R-RNO-380270, Recruitment of mitotic centrosome proteins and complexes
R-RNO-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-RNO-380320, Recruitment of NuMA to mitotic centrosomes
R-RNO-389513, CTLA4 inhibitory signaling
R-RNO-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-RNO-5620912, Anchoring of the basal body to the plasma membrane
R-RNO-5663220, RHO GTPases Activate Formins
R-RNO-5673000, RAF activation
R-RNO-5675221, Negative regulation of MAPK pathway
R-RNO-6804757, Regulation of TP53 Degradation
R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-68877, Mitotic Prometaphase
R-RNO-69231, Cyclin D associated events in G1
R-RNO-69273, Cyclin A/B1/B2 associated events during G2/M transition
R-RNO-8854518, AURKA Activation by TPX2
R-RNO-9648025, EML4 and NUDC in mitotic spindle formation
R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Gene expression databases

BgeeiENSRNOG00000011282, Expressed in brain and 21 other tissues

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR000357, HEAT
IPR021133, HEAT_type_2
IPR031090, PP2A_A_meta
PANTHERiPTHR10648:SF2, PTHR10648:SF2, 1 hit
PfamiView protein in Pfam
PF02985, HEAT, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077, HEAT_REPEAT, 11 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5XI34_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5XI34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: April 7, 2021
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again