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Entry version 82 (02 Dec 2020)
Sequence version 1 (23 Nov 2004)
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Protein

Centrosomal protein of 95 kDa

Gene

Cep95

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 95 kDa
Short name:
Cep95
Alternative name(s):
Coiled-coil domain-containing protein 45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cep95
Synonyms:Ccdc45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
1309655, Cep95

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002345071 – 821Centrosomal protein of 95 kDaAdd BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei445PhosphoserineBy similarity1
Modified residuei447PhosphoserineBy similarity1
Modified residuei449PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5XI03

PRoteomics IDEntifications database

More...
PRIDEi
Q5XI03

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q5XI03

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5XI03

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5XI03

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000014354, Expressed in testis and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5XI03, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000062563

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5XI03

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili578 – 627Sequence analysisAdd BLAST50
Coiled coili695 – 789Sequence analysisAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi235 – 238Poly-Glu4
Compositional biasi504 – 510Poly-Glu7

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTFE, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005412

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018428_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5XI03

Identification of Orthologs from Complete Genome Data

More...
OMAi
KHSQPWK

Database of Orthologous Groups

More...
OrthoDBi
1353802at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026619, CEP95
IPR044039, DUF5745

The PANTHER Classification System

More...
PANTHERi
PTHR22545, PTHR22545, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF19016, DUF5745, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5XI03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSEAEWVT IANNLLFKCH IHLRIHKLQD CDANVFIALY QSILGEKVPD
60 70 80 90 100
LIVIPRSQED NAHNVQAVID SLALDYLQVS LSHITGENIV KGDKGSIKNL
110 120 130 140 150
LEIFDGLLEY LTEHISESSH NRSASEQFCR DSRGEEPVEE LESAKESSWR
160 170 180 190 200
KVPFMRCSFS PDALGPTWDE EEAESTGEII RLGDTAHTFS LRSNGAQNSM
210 220 230 240 250
NFWSRKASTS GIRPPEEMLN PGLSSFLFKN GPTCEEEEAP PIHMATSARK
260 270 280 290 300
LGEPIRAAIP LHPPYHPPEP RAPCPIGKEY LCSGHYLSTP ASGEHRAPSV
310 320 330 340 350
EPGDVFLTST LCKDDDQETD LDLTESSKTR RLSKGERSEN RAVAPSEYPP
360 370 380 390 400
FPQKARKRLT EQELHAMSEK LSQRLSELDW MLKTALGDRA TGEAHGKDGG
410 420 430 440 450
AGDEEAHSAN EEMLSQHSDS VMEYGPRKPR PGFSMHRKAP YRSHSLSPSS
460 470 480 490 500
VNKHRQSEKE RKKQHKSKGT DTHHFQAKAL TEAFERELRK NKVQENVGLR
510 520 530 540 550
GIREEEEETE KSYKEAFAKG TTKQSQVQKI YSRKTAAPTP KGGLLKSSKA
560 570 580 590 600
SPMKVNEHSL LSLMLEQFPF LYVSDPTLTK MWKQQMAQVE QLRREAQREN
610 620 630 640 650
RSKKKLQDEI EEALRRHDLL TALVKKEYDH NKRLQDFKDR IHKQRLTQSK
660 670 680 690 700
IKENRHQSVR ARKYYDDYRV QLRAKMMKMR TREEMIFKKL FEEGLQIQKQ
710 720 730 740 750
RLRDLRNYAK EKRSEEKRQH QNELDSMENY YKDQFSLLAE AISQGRQELK
760 770 780 790 800
ARQRSQAQTL HKVKRELRAK MEKEIEQLQH LITQSDDDAF FRELEAERFK
810 820
ARLQLASFQY SKNPFPRGQT P
Length:821
Mass (Da):94,508
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE8F6F621FFE2F05
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC083896 mRNA Translation: AAH83896.1

NCBI Reference Sequences

More...
RefSeqi
NP_001013884.1, NM_001013862.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000066525; ENSRNOP00000062563; ENSRNOG00000014354

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
287766

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:287766

UCSC genome browser

More...
UCSCi
RGD:1309655, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC083896 mRNA Translation: AAH83896.1
RefSeqiNP_001013884.1, NM_001013862.1

3D structure databases

SMRiQ5XI03
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062563

PTM databases

CarbonylDBiQ5XI03
iPTMnetiQ5XI03
PhosphoSitePlusiQ5XI03

Proteomic databases

PaxDbiQ5XI03
PRIDEiQ5XI03

Genome annotation databases

EnsembliENSRNOT00000066525; ENSRNOP00000062563; ENSRNOG00000014354
GeneIDi287766
KEGGirno:287766
UCSCiRGD:1309655, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90799
RGDi1309655, Cep95

Phylogenomic databases

eggNOGiENOG502QTFE, Eukaryota
GeneTreeiENSGT00390000005412
HOGENOMiCLU_018428_1_0_1
InParanoidiQ5XI03
OMAiKHSQPWK
OrthoDBi1353802at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5XI03

Gene expression databases

BgeeiENSRNOG00000014354, Expressed in testis and 21 other tissues
GenevisibleiQ5XI03, RN

Family and domain databases

InterProiView protein in InterPro
IPR026619, CEP95
IPR044039, DUF5745
PANTHERiPTHR22545, PTHR22545, 1 hit
PfamiView protein in Pfam
PF19016, DUF5745, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEP95_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5XI03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 23, 2004
Last modified: December 2, 2020
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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