UniProtKB - Q5XHC5 (IBP2_XENLA)
Protein
Insulin-like growth factor-binding protein 2
Gene
igfbp2
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity).By similarity
GO - Molecular functioni
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- regulation of growth Source: UniProtKB-KW
- regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Growth factor binding |
Biological process | Growth regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 2By similarityShort name: IGF-binding protein 2By similarity Short name: IGFBP-2By similarity |
Gene namesi | Name:igfbp2 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-865692, igfbp2.L |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000381736 | 22 – 281 | Insulin-like growth factor-binding protein 2Sequence analysisAdd BLAST | 260 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 183 ↔ 217 | PROSITE-ProRule annotationBy similarity | ||
Disulfide bondi | 228 ↔ 239 | PROSITE-ProRule annotationBy similarity | ||
Disulfide bondi | 241 ↔ 262 | PROSITE-ProRule annotationBy similarity |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Interacts with igf1 and igf2.
By similarityGO - Molecular functioni
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 106 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 180 – 262 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 83 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 257 – 259 | Cell attachment siteSequence analysis | 3 |
Keywords - Domaini
SignalPhylogenomic databases
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5XHC5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLSEHLLVL LGAVLCAPAL SDVLFRCPPC SPERLAACPG NSPRSPCAEL
60 70 80 90 100
VRAPGCGCCP VCARLEGESC GVYTARCAGG LRCYPHPGSE LPLQALVLGL
110 120 130 140 150
GTCGKRRDAE YGSSQERGTE LPEDQSDNML VDNNLVAGPA VPGDFMPRKS
160 170 180 190 200
SKAHAVNRER ANEQHRSKTN KSEDKKRPAR SLCQLQLDQV LERISGMHLP
210 220 230 240 250
DDRGPLEHLY ALPIPNCDKN GFFNLKQCKM SVNGQRGECW CVNPITGKVL
260 270 280
PGSPTVRGDP ECHLFYTNPE EERRAHTQRA P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC084133 mRNA Translation: AAH84133.1 |
RefSeqi | XP_018091144.1, XM_018235655.1 |
Genome annotation databases
GeneIDi | 108701262 |
KEGGi | xla:108701262 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC084133 mRNA Translation: AAH84133.1 |
RefSeqi | XP_018091144.1, XM_018235655.1 |
3D structure databases
SMRi | Q5XHC5 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 108701262 |
KEGGi | xla:108701262 |
Organism-specific databases
Xenbasei | XB-GENE-865692, igfbp2.L |
Phylogenomic databases
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP2_XENLA | |
Accessioni | Q5XHC5Primary (citable) accession number: Q5XHC5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 1, 2009 |
Last sequence update: | November 23, 2004 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |