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Protein

Transmembrane protein 178A

Gene

tmem178a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a negative regulator of osteoclast differentiation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 178A
Gene namesi
Name:tmem178a
Synonyms:tmem178.1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-942690 tmem178a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 186ExtracellularSequence analysisAdd BLAST161
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 215CytoplasmicSequence analysis8
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 267ExtracellularSequence analysisAdd BLAST31
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 304CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028728426 – 304Transmembrane protein 178AAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM178 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG070972

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR039625 T178A/B
PANTHERiPTHR32005 PTHR32005, 1 hit
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5XGU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESRGLVTAV SLTLSICSLL LLVTAIFTDH WYETDTRKHK EMCDSQGNSD
60 70 80 90 100
PTEQKNRLMP LYQLPFRGDP SNTRRLGLLS PAPAGGVREP EDLLENWRSL
110 120 130 140 150
LGLGVLESDC GRPLFSTYSG LWRKCYIMGI DKDIDSLIIK GIAQKCTAIK
160 170 180 190 200
YHFSHPIRLR NIPFNLTRAI QQDEWHLLHL RRITAGFLGM AAAVLLCGCI
210 220 230 240 250
VAAISFFWEE SLTQHVAGLL FLMTGIFCTI SLCTYAASVA YELNRQPKFI
260 270 280 290 300
YGLPSDVEHG YSWSLFCAWC SLGLIVAAGC LCTAYPFISR TKILHLKFAR

DSCV
Length:304
Mass (Da):34,065
Last modified:November 23, 2004 - v1
Checksum:iDBD7876BE9B79E2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084338 mRNA Translation: AAH84338.1
RefSeqiNP_001088305.1, NM_001094836.1
UniGeneiXl.49104

Genome annotation databases

GeneIDi495141
KEGGixla:495141

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084338 mRNA Translation: AAH84338.1
RefSeqiNP_001088305.1, NM_001094836.1
UniGeneiXl.49104

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi495141
KEGGixla:495141

Organism-specific databases

CTDi495141
XenbaseiXB-GENE-942690 tmem178a

Phylogenomic databases

HOVERGENiHBG070972

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR039625 T178A/B
PANTHERiPTHR32005 PTHR32005, 1 hit
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT178A_XENLA
AccessioniPrimary (citable) accession number: Q5XGU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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