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Entry version 121 (23 Feb 2022)
Sequence version 1 (23 Nov 2004)
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Protein

Probable cation-transporting ATPase 13A4

Gene

Atp13a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4874-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi849MagnesiumBy similarity1
Metal bindingi853MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-936837, Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A4 (EC:7.2.2.-)
Alternative name(s):
P5-ATPase isoform 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atp13a4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924456, Atp13a4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32Cytoplasmic1 PublicationAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei33 – 531 PublicationAdd BLAST21
Topological domaini54 – 198Cytoplasmic1 PublicationAdd BLAST145
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 224Lumenal1 Publication5
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 401Cytoplasmic1 PublicationAdd BLAST156
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 437Lumenal1 PublicationAdd BLAST15
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 901Cytoplasmic1 PublicationAdd BLAST443
Transmembranei902 – 922HelicalSequence analysisAdd BLAST21
Topological domaini923 – 933Lumenal1 PublicationAdd BLAST11
Transmembranei934 – 954HelicalSequence analysisAdd BLAST21
Topological domaini955 – 973Cytoplasmic1 PublicationAdd BLAST19
Transmembranei974 – 994HelicalSequence analysisAdd BLAST21
Topological domaini995 – 1036Lumenal1 PublicationAdd BLAST42
Transmembranei1037 – 1057HelicalSequence analysisAdd BLAST21
Topological domaini1058 – 1071Cytoplasmic1 PublicationAdd BLAST14
Transmembranei1072 – 1092HelicalSequence analysisAdd BLAST21
Topological domaini1093 – 1105Lumenal1 PublicationAdd BLAST13
Transmembranei1106 – 1126HelicalSequence analysisAdd BLAST21
Topological domaini1127 – 1193Cytoplasmic1 PublicationAdd BLAST67

Keywords - Cellular componenti

Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003186761 – 1193Probable cation-transporting ATPase 13A4Add BLAST1193

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5XF90

PRoteomics IDEntifications database

More...
PRIDEi
Q5XF90

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
277051 [Q5XF90-1]
277052 [Q5XF90-2]
277053 [Q5XF90-3]
277054 [Q5XF90-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5XF90

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5XF90

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and stomach.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000138479

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5XF90, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5XF90

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0208, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5XF90

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5XF90

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDF00027, p-type_atpase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00831, Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01494, ATPase_P-type, 1 hit
TIGR01657, P-ATPase-V, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5XF90-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDHLEKSQH ALLNEGDENE MEIFGYRTQG CRKALCLIGS IFSLGMLPLV
60 70 80 90 100
FYWRPAWRVW ANCVPCSLQE ADVVLLKTTD EFKIYSWKKV IWISLSALSS
110 120 130 140 150
TSGLTPDHPL ITDEGYIINR AIRKPDLKVR YIKVQKIRYV WNNLEGQFQK
160 170 180 190 200
IGSLEDWLSS AKIHQKFGLG LTSEEQEIRR LICGPNAIDV EITPIWKLLI
210 220 230 240 250
KEVLNPFYIF QLFSVCLWFS EDYKEYALAI ILMSVISIAL TVYDLRQQSV
260 270 280 290 300
KLHHLVESHN SITVSVYERK AGAQDLESRL LVPGDLLILT GSRVQMPCDA
310 320 330 340 350
ILIDGSCVVD EGMLTGESIP VTKTPLSQTA SSVPWKMQSE ADPRRHVLFC
360 370 380 390 400
GTEVIQAKAA GSGAVRAVVL QTGFNTAKGD LVRSILYPKP MNFKLYRDAI
410 420 430 440 450
RFLLCLVGTA TIGMVYTLCV YVLSGEPPEE VVRKALDVIT IAVPPALPAA
460 470 480 490 500
LTTGIIYAQR RLKKKGIFCI SPQRINVCGQ LNLVCFDKTG TLTRGGLDPW
510 520 530 540 550
GVVPCDQNGF QAVHSFASGK ALPQGPLCAA MASCHSLILL DGTIQGDPLD
560 570 580 590 600
LKMFEATKWE MTASGDDLHI KEMLAHTIVV KPTDMVGQVP AEGLAIVHQF
610 620 630 640 650
PFSSALQRMT VIVQEMGGGR LAFMKGAPER VASFCQPDTV PTSFISELQI
660 670 680 690 700
YTTQGFRVIA LAYKKLEMDC PTTALMREKV ESDLVFLGLL ILENRLKEET
710 720 730 740 750
KPVLEELISA RIRTVMITGD NLQTAITVAR KSGMVSEGQK VILVEANEAT
760 770 780 790 800
GSSSASISWK LVEEKKPGPF GSQDTYINIR EEVPENGRDR SYHFALSGKS
810 820 830 840 850
FHVISQYFSS LLPKILINGT IFARMSPGQK SSLVEEFQKL DYFVGMCGDG
860 870 880 890 900
ANDCGALKMA HVGISLSEQE ASVASPFTSK TPNIECVPHL IKEGRAALVT
910 920 930 940 950
SFCMFKYMAL YSMIQYVGVL LLYWKTNSLS NYQFLFQDLA ITTLIGVTMN
960 970 980 990 1000
LNGANPKLVP FRPAGRLISP PLLLSVVLNI LLSLAMHIVG FILVQKQPWY
1010 1020 1030 1040 1050
IMDYHSVCPV RNESASALAA SPSVPEKTRS NSTFASFENT TIWFLGTINC
1060 1070 1080 1090 1100
IFVALVFSKG KPFRQPTYTN YIFVLVLILQ MGVCLFILFA DIPEMHRRLD
1110 1120 1130 1140 1150
LLCTPVLWRV YILIMISSNF VVSLAVEKAI IENRALWIAV KRCFGYQSKS
1160 1170 1180 1190
QYRIWQRNLA NDSSWPPLNQ TSYSDMQGVS YSNPVFESNE EQL
Length:1,193
Mass (Da):132,804
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69C30D087163A24A
GO
Isoform 2 (identifier: Q5XF90-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-425: Missing.

Show »
Length:1,174
Mass (Da):130,875
Checksum:iBD109B4F54FEE030
GO
Isoform 3 (identifier: Q5XF90-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-295: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:898
Mass (Da):98,960
Checksum:i85B4D3F05EEFE522
GO
Isoform 4 (identifier: Q5XF90-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     815-878: ILINGTIFAR...QEASVASPFT → LVMNNFLGSS...GFNYTGHLKK
     879-1193: Missing.

Show »
Length:878
Mass (Da):97,411
Checksum:iAF4DBECD94F7CE14
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QPP7E9QPP7_MOUSE
Cation-transporting ATPase
Atp13a4
1,174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J0M2A0A0R4J0M2_MOUSE
Cation-transporting ATPase
Atp13a4
878Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2B9S4R2B9_MOUSE
Cation-transporting ATPase
Atp13a4
84Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R234S4R234_MOUSE
Cation-transporting ATPase
Atp13a4
1,193Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2M1S4R2M1_MOUSE
Probable cation-transporting ATPase...
Atp13a4
576Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R262S4R262_MOUSE
Probable cation-transporting ATPase...
Atp13a4
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti568L → F in BAC26113 (PubMed:16141072).Curated1
Sequence conflicti568L → F in BAC26383 (PubMed:16141072).Curated1
Sequence conflicti587G → A in BAC26113 (PubMed:16141072).Curated1
Sequence conflicti587G → A in BAC26383 (PubMed:16141072).Curated1
Sequence conflicti790R → G in BAC26113 (PubMed:16141072).Curated1
Sequence conflicti790R → G in BAC26383 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0312621 – 295Missing in isoform 3. 1 PublicationAdd BLAST295
Alternative sequenceiVSP_031263407 – 425Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_031264815 – 878ILING…ASPFT → LVMNNFLGSSCVFAFSWVLL YVSIVIPRIPLVQLSVKLKI FQDMAEKAVFSMAAGFNYTG HLKK in isoform 4. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_031265879 – 1193Missing in isoform 4. 1 PublicationAdd BLAST315

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK028776 mRNA Translation: BAC26113.1
AK029303 mRNA Translation: BAC26383.1
AC175464 Genomic DNA No translation available.
BC048410 mRNA Translation: AAH48410.1
BK005557 mRNA Translation: DAA05588.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49816.1 [Q5XF90-1]
CCDS49817.1 [Q5XF90-4]
CCDS59623.1 [Q5XF90-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001158085.1, NM_001164613.1
XP_017172445.1, XM_017316956.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
224079

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:224079

UCSC genome browser

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UCSCi
uc007ywd.2, mouse [Q5XF90-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028776 mRNA Translation: BAC26113.1
AK029303 mRNA Translation: BAC26383.1
AC175464 Genomic DNA No translation available.
BC048410 mRNA Translation: AAH48410.1
BK005557 mRNA Translation: DAA05588.1
CCDSiCCDS49816.1 [Q5XF90-1]
CCDS49817.1 [Q5XF90-4]
CCDS59623.1 [Q5XF90-2]
RefSeqiNP_001158085.1, NM_001164613.1
XP_017172445.1, XM_017316956.1

3D structure databases

SMRiQ5XF90
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000138479

PTM databases

iPTMnetiQ5XF90
PhosphoSitePlusiQ5XF90

Proteomic databases

PaxDbiQ5XF90
PRIDEiQ5XF90
ProteomicsDBi277051 [Q5XF90-1]
277052 [Q5XF90-2]
277053 [Q5XF90-3]
277054 [Q5XF90-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
224079

Genome annotation databases

GeneIDi224079
KEGGimmu:224079
UCSCiuc007ywd.2, mouse [Q5XF90-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84239
MGIiMGI:1924456, Atp13a4

Phylogenomic databases

eggNOGiKOG0208, Eukaryota
InParanoidiQ5XF90
PhylomeDBiQ5XF90

Enzyme and pathway databases

ReactomeiR-MMU-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
224079, 0 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Atp13a4, mouse

Protein Ontology

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PROi
PR:Q5XF90
RNActiQ5XF90, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom
PfamiView protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SMARTiView protein in SMART
SM00831, Cation_ATPase_N, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01494, ATPase_P-type, 1 hit
TIGR01657, P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT134_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5XF90
Secondary accession number(s): Q80V28, Q8C105, Q8C184
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: February 23, 2022
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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