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Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Dihydroneopterin aldolase (folB)
  4. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00155

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Ordered Locus Names:M6_Spy0822
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682621 – 1662-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd BLAST166

Proteomic databases

PRIDEiQ5XCA6

Structurei

3D structure databases

ProteinModelPortaliQ5XCA6
SMRiQ5XCA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.Curated

Phylogenomic databases

HOGENOMiHOG000217741
KOiK00950
OMAiKDERWGP

Family and domain databases

CDDicd00483 HPPK, 1 hit
Gene3Di3.30.70.560, 1 hit
InterProiView protein in InterPro
IPR000550 Hppk
IPR035907 Hppk_sf
PfamiView protein in Pfam
PF01288 HPPK, 1 hit
SUPFAMiSSF55083 SSF55083, 1 hit
TIGRFAMsiTIGR01498 folK, 1 hit
PROSITEiView protein in PROSITE
PS00794 HPPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XCA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIVYLSLGT NMGDRAAYLQ KALEALADLP QTRLLAQSSI YETTAWGKTG
60 70 80 90 100
QADFLNMACQ LDTQLTAADF LKETQAIEQS LGRVRHEKWG SRTIDIDILL
110 120 130 140 150
FGEEVYDTKE LKVPHPYMTE RAFVLIPLLE LQSDLKLPPN HKFLRDYLAA
160
LDQSDITLFS AQQTEF
Length:166
Mass (Da):18,813
Last modified:November 23, 2004 - v1
Checksum:i52435CEA8BF70A3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA Translation: AAT86957.1
RefSeqiWP_009880425.1, NC_006086.1

Genome annotation databases

EnsemblBacteriaiAAT86957; AAT86957; M6_Spy0822
KEGGispa:M6_Spy0822

Entry informationi

Entry nameiHPPK_STRP6
AccessioniPrimary (citable) accession number: Q5XCA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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