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Protein

Guanylate kinase

Gene

gmk

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:M6_Spy1387
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001706221 – 211Guanylate kinaseAdd BLAST211

Structurei

3D structure databases

ProteinModelPortaliQ5XAP1
SMRiQ5XAP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 184Guanylate kinase-likeUniRule annotationAdd BLAST180

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000037639
KOiK00942
OMAiAGNYYGT

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XAP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERGLLIVF SGPSGVGKGT VRQEIFSTPD HKFEYSVSMT TRPQRPGEVD
60 70 80 90 100
GVDYFFRTRE EFEELIKTGQ MLEYAEYVGN YYGTPLTYVN ETLDKGIDVF
110 120 130 140 150
LEIEVQGALQ VKSKVPDGVF VFLTPPDLDE LEDRLVGRGT DSQEVIAQRI
160 170 180 190 200
ERAKEEIALM REYDYAVVND EVALAAERVK RIIETEHFRV ERVIGRYDKM
210
IKITKNPFKA K
Length:211
Mass (Da):24,186
Last modified:November 23, 2004 - v1
Checksum:i296B236E67A925D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA Translation: AAT87522.1
RefSeqiWP_002983649.1, NC_006086.1

Genome annotation databases

EnsemblBacteriaiAAT87522; AAT87522; M6_Spy1387
KEGGispa:M6_Spy1387

Similar proteinsi

Entry informationi

Entry nameiKGUA_STRP6
AccessioniPrimary (citable) accession number: Q5XAP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome