UniProtKB - Q5XAK0 (GLPO_STRP6)
Protein
Alpha-glycerophosphate oxidase
Gene
glpO
Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Functioni
Caution
As S.pyogenes is unable to produce acid from glycerol, the significance and/or function of the glpO gene in this organism is at present unknown.Curated
Catalytic activityi
- EC:1.1.3.21
Cofactori
FADBy similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 21 – 49 | FADSequence analysisAdd BLAST | 29 |
GO - Molecular functioni
- glycerol-3-phosphate dehydrogenase (quinone) activity Source: InterPro
- glycerol-3-phosphate oxidase activity Source: UniProtKB-EC
GO - Biological processi
- glycerol-3-phosphate metabolic process Source: InterPro
- glycerol metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Glycerol metabolism |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
BioCyci | SPYO286636:G1G3V-1473-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-glycerophosphate oxidase (EC:1.1.3.21)Alternative name(s): Glycerol-3-phosphate oxidase |
Gene namesi | Name:glpO Synonyms:glpA Ordered Locus Names:M6_Spy1428 |
Organismi | Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) |
Taxonomic identifieri | 286636 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- glycerol-3-phosphate dehydrogenase complex Source: InterPro
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000126112 | 1 – 612 | Alpha-glycerophosphate oxidaseAdd BLAST | 612 |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.Curated
Phylogenomic databases
HOGENOMi | CLU_015740_5_2_9 |
OMAi | AHGFSKT |
Family and domain databases
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SUPFAMi | SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00977, FAD_G3PDH_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5XAK0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFSKETRRL ALQKMQERDL DLLIIGGGIT GAGVALQAAA SGLDTGLIEM
60 70 80 90 100
QDFAEGTSSR STKLVHGGLR YLKQFDVEVV SDTVSERAVV QQIAPHIPKP
110 120 130 140 150
DPMLLPVYDE PGSTFSMFRL KVAMDLYDLL AGVSNTPAAN KVLTKEEVLK
160 170 180 190 200
REPDLKQEGL LGGGVYLDFR NNDARLVIEN IKRANRDGAL IASHVKAEDF
210 220 230 240 250
LLDDKRQIIG VKARDLLTDQ EIIIKAKLVI NTTGPWSDEI RQFSHKGQPI
260 270 280 290 300
HQMRPTKGVH LVVDRQKLPV SQPVYVDTGL NDGRMVFVLP REEKTYFGTT
310 320 330 340 350
DTDYTGDLQH PQVTQEDVDY LLGIVNNRFP NANLTINDIE SSWAGLRPLL
360 370 380 390 400
SGNSASDYNG GNSGKLSDDS FDHLIDTVKA YINHEDSREA VEKAIKQVET
410 420 430 440 450
STSEKELDPS AVSRGSSFER DENGLFTLAG GKITDYRKMA EGALKVIIQV
460 470 480 490 500
LKEDFGKSFK LINSTTYPVS GGEINPANVD SELEAYAQLG TLSGLSMDDA
510 520 530 540 550
RYLANLYGSN APKVFALTRQ LKAAEGLSLA ETLSLHYAMD YEMALKPTDY
560 570 580 590 600
FLRRTNHLLF MRDSLDALIV PVIEEMAKHF DWSTDEKVKQ EEELRRVIAE
610
NDLSALKGQQ ED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000003 Genomic DNA Translation: AAT87563.1 |
RefSeqi | WP_011184846.1, NC_006086.1 |
Genome annotation databases
EnsemblBacteriai | AAT87563; AAT87563; M6_Spy1428 |
KEGGi | spa:M6_Spy1428 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000003 Genomic DNA Translation: AAT87563.1 |
RefSeqi | WP_011184846.1, NC_006086.1 |
3D structure databases
SMRi | Q5XAK0 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAT87563; AAT87563; M6_Spy1428 |
KEGGi | spa:M6_Spy1428 |
Phylogenomic databases
HOGENOMi | CLU_015740_5_2_9 |
OMAi | AHGFSKT |
Enzyme and pathway databases
BioCyci | SPYO286636:G1G3V-1473-MONOMER |
Family and domain databases
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SUPFAMi | SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00977, FAD_G3PDH_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLPO_STRP6 | |
Accessioni | Q5XAK0Primary (citable) accession number: Q5XAK0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | November 23, 2004 | |
Last modified: | February 10, 2021 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |