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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi58MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:M6_Spy1525
OrganismiStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Taxonomic identifieri286636 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001167 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001757171 – 118Holo-[acyl-carrier-protein] synthaseAdd BLAST118

Structurei

3D structure databases

ProteinModelPortaliQ5XAA3
SMRiQ5XAA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000014315
KOiK00997
OMAiDERHYAV

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

Q5XAA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVGHGIDLQ EISAIEKVYQ RNPRFAQKIL TEQELAIFES FPYKRRLSYL
60 70 80 90 100
AGRWSGKEAF AKAIGTGIGR LTFQDIEILN DVRGCPILTK SPFKGNSFIS
110
ISHSGNYVQA SVILEDKK
Length:118
Mass (Da):13,262
Last modified:November 23, 2004 - v1
Checksum:i5AFE6F77EE64BDBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000003 Genomic DNA Translation: AAT87660.1
RefSeqiWP_002983199.1, NC_006086.1

Genome annotation databases

EnsemblBacteriaiAAT87660; AAT87660; M6_Spy1525
KEGGispa:M6_Spy1525

Similar proteinsi

Entry informationi

Entry nameiACPS_STRP6
AccessioniPrimary (citable) accession number: Q5XAA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health