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Protein

Protoheme IX farnesyltransferase

Gene

cyoE

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.UniRule annotation

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.UniRule annotation

Pathwayi: heme O biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes heme O from protoheme.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Protoheme IX farnesyltransferase (cyoE)
This subpathway is part of the pathway heme O biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes heme O from protoheme, the pathway heme O biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processHeme biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00834;UER00712

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
Heme B farnesyltransferaseUniRule annotation
Heme O synthaseUniRule annotation
Gene namesi
Name:cyoEUniRule annotation
Ordered Locus Names:lpp0479
OrganismiLegionella pneumophila (strain Paris)
Taxonomic identifieri297246 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Organism-specific databases

LegioListilpp0479

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalUniRule annotationAdd BLAST21
Transmembranei48 – 68HelicalUniRule annotationAdd BLAST21
Transmembranei96 – 116HelicalUniRule annotationAdd BLAST21
Transmembranei118 – 138HelicalUniRule annotationAdd BLAST21
Transmembranei146 – 166HelicalUniRule annotationAdd BLAST21
Transmembranei172 – 192HelicalUniRule annotationAdd BLAST21
Transmembranei224 – 244HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21
Transmembranei268 – 288HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003269071 – 294Protoheme IX farnesyltransferaseAdd BLAST294

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105F1R Bacteria
COG0109 LUCA
HOGENOMiHOG000237291
KOiK02257
OMAiHRKEEYA
OrthoDBiPOG091H05F2

Family and domain databases

CDDicd13957 PT_UbiA_Cox10, 1 hit
HAMAPiMF_00154 CyoE_CtaB, 1 hit
InterProiView protein in InterPro
IPR006369 Protohaem_IX_farnesylTrfase
IPR000537 UbiA_prenyltransferase
IPR030470 UbiA_prenylTrfase_CS
PANTHERiPTHR43448 PTHR43448, 1 hit
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
TIGRFAMsiTIGR01473 cyoE_ctaB, 1 hit
PROSITEiView protein in PROSITE
PS00943 UBIA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5X7X6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTEYAARLP VDWRDYVELC KPRVVLLMLL TVIVGMYLAA PGWVSLRLIA
60 70 80 90 100
FTLLGIGLCA GSAAAINHLV DRHIDSIMAR TKKRPVAYGR VSVKQALWFA
110 120 130 140 150
VIIGLMGLSL LILFVNQLTA LLTFVTLIGY AGVYTGYLKR ATSQNIVIGG
160 170 180 190 200
LAGAAPPLLG WTAVTGQLDP QALLLVLIIF TWTPPHFWAL AIYRYKEYQD
210 220 230 240 250
AEIPMLPVTH GIQFTKLNIY LYTVLLLVVS LLPFVVSMSG WIYLLGALVL
260 270 280 290
GIRFLVWAHK LYFTDKPVVA MQTFRFSILY LMLLFVFLLV DHYF
Length:294
Mass (Da):33,000
Last modified:November 23, 2004 - v1
Checksum:i1A547F58E552E409
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA Translation: CAH11627.1
RefSeqiWP_011213062.1, NC_006368.1

Genome annotation databases

EnsemblBacteriaiCAH11627; CAH11627; lpp0479
KEGGilpp:lpp0479

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA Translation: CAH11627.1
RefSeqiWP_011213062.1, NC_006368.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH11627; CAH11627; lpp0479
KEGGilpp:lpp0479

Organism-specific databases

LegioListilpp0479

Phylogenomic databases

eggNOGiENOG4105F1R Bacteria
COG0109 LUCA
HOGENOMiHOG000237291
KOiK02257
OMAiHRKEEYA
OrthoDBiPOG091H05F2

Enzyme and pathway databases

UniPathwayi
UPA00834;UER00712

Family and domain databases

CDDicd13957 PT_UbiA_Cox10, 1 hit
HAMAPiMF_00154 CyoE_CtaB, 1 hit
InterProiView protein in InterPro
IPR006369 Protohaem_IX_farnesylTrfase
IPR000537 UbiA_prenyltransferase
IPR030470 UbiA_prenylTrfase_CS
PANTHERiPTHR43448 PTHR43448, 1 hit
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
TIGRFAMsiTIGR01473 cyoE_ctaB, 1 hit
PROSITEiView protein in PROSITE
PS00943 UBIA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYOE_LEGPA
AccessioniPrimary (citable) accession number: Q5X7X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 23, 2004
Last modified: October 10, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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