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Entry version 94 (07 Apr 2021)
Sequence version 1 (23 Nov 2004)
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Protein

Fe(2+) transporter FeoB

Gene

feoB

Organism
Legionella pneumophila (strain Paris)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transporter of a GTP-driven Fe2+ uptake system.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi8 – 15GTP 1PROSITE-ProRule annotation8
Nucleotide bindingi33 – 37GTP 2PROSITE-ProRule annotation5
Nucleotide bindingi54 – 57GTP 3PROSITE-ProRule annotation4
Nucleotide bindingi118 – 121GTPPROSITE-ProRule annotation4
Nucleotide bindingi147 – 149GTPPROSITE-ProRule annotation3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transport, Transport
LigandGTP-binding, Iron, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.8.1.12, the ferrous iron uptake (feob) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fe(2+) transporter FeoBCurated
Alternative name(s):
Ferrous iron transport protein B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:feoB
Ordered Locus Names:lpp2711
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLegionella pneumophila (strain Paris)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri297246 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Organism-specific databases

Legionella pneumophila genome database

More...
LegioListi
lpp2711

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Transmembranei657 – 677HelicalSequence analysisAdd BLAST21
Transmembranei685 – 705HelicalSequence analysisAdd BLAST21
Transmembranei715 – 735HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002108331 – 751Fe(2+) transporter FeoBAdd BLAST751

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5X1N2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 167FeoB-type GPROSITE-ProRule annotationAdd BLAST167

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013350_3_0_6

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEMPDYE

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01879, FeoB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003373, Fe2_transport_prot-B
IPR011640, Fe2_transport_prot_B_C
IPR030389, G_FEOB_dom
IPR011642, Gate_dom
IPR006073, GTP-bd
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07664, FeoB_C, 1 hit
PF02421, FeoB_N, 1 hit
PF07670, Gate, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00326, GTP1OBG

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00437, feoB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51711, G_FEOB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5X1N2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHALLIGNP NCGKTTLFNA LTNANQRVGN WPGVTVEKKT GEFLLGEHLI
60 70 80 90 100
EITDLPGVYS LVANAEGISQ DEQIAAQSVI DLEYDCIINV IDACHLERHL
110 120 130 140 150
YLTSQLFELG KPVVVALNMM DIAEHRGISI DTEKLESLLG CSVIPIQAHK
160 170 180 190 200
NIGIPALQQS LLHCSQKIKP LKLSLSVAAQ QILNDLENQL ISKGYKNSFA
210 220 230 240 250
YYFSRRLAEG DTLIGEKAFT ESLLIKLQET EQNLDVLLAD ARYQKIHEIV
260 270 280 290 300
TLVQKKHSDA SEHFTAKLDK LVLHRFLALP IFFAMMYLMF LFAINIGGAF
310 320 330 340 350
QDFFDISTET IFVQGSGWLL QQLHAPNWVI ALVANGVGKG INTTITFIPV
360 370 380 390 400
IAAMFFFLSL LETSGYMARA AFVVDKAMRA MGLPGKSFVP MIVGFGCNVP
410 420 430 440 450
AIMAARTLDS ERDRLLTVMM SPFMSCSARL AIYAVFVAAF FPSGGHNVVF
460 470 480 490 500
SLYLIGILMA VFTGYILRKT TLKGHASPLI LELPAYHRPS LRRLLRETSL
510 520 530 540 550
RLRFFVYRAG KLIIPICVIL GGLNAITWGG GISSGEANTD SLLSIIGQWI
560 570 580 590 600
TPLFAPMGIH QDNWPATVGL LTGMLAKEVV VGTLNSLYAQ VGHVGEIAAA
610 620 630 640 650
HFDFWGGIKA AFGSIPANLS ELGSALWNPV SASAADSELS QSVYGIMSRR
660 670 680 690 700
FDGAVGAYAY LLFVLLYIPC VSTMAVIRQE ANKRFMWTSI VWSFVVAYTT
710 720 730 740 750
SVVFYQGAKF LDHPQQSMIW ILAMSLSLLF VLAVFRYSQY GMGRQNAAAN

T
Length:751
Mass (Da):82,528
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6B183CDF26D619C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR628336 Genomic DNA Translation: CAH13864.1

NCBI Reference Sequences

More...
RefSeqi
WP_015961734.1, NC_006368.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lpp:lpp2711

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628336 Genomic DNA Translation: CAH13864.1
RefSeqiWP_015961734.1, NC_006368.1

3D structure databases

SMRiQ5X1N2
ModBaseiSearch...

Protein family/group databases

TCDBi9.A.8.1.12, the ferrous iron uptake (feob) family

Genome annotation databases

KEGGilpp:lpp2711

Organism-specific databases

LegioListilpp2711

Phylogenomic databases

HOGENOMiCLU_013350_3_0_6
OMAiMEMPDYE

Family and domain databases

CDDicd01879, FeoB, 1 hit
InterProiView protein in InterPro
IPR003373, Fe2_transport_prot-B
IPR011640, Fe2_transport_prot_B_C
IPR030389, G_FEOB_dom
IPR011642, Gate_dom
IPR006073, GTP-bd
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF07664, FeoB_C, 1 hit
PF02421, FeoB_N, 1 hit
PF07670, Gate, 2 hits
PRINTSiPR00326, GTP1OBG
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00437, feoB, 1 hit
PROSITEiView protein in PROSITE
PS51711, G_FEOB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFEOB_LEGPA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5X1N2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: April 7, 2021
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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