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Protein

Lymphotoxin-alpha

Gene

LTA

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-CFA-5668541 TNFR2 non-canonical NF-kB pathway
R-CFA-5669034 TNFs bind their physiological receptors
R-CFA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotoxin-alpha
Short name:
LT-alpha
Alternative name(s):
TNF-beta
Tumor necrosis factor ligand superfamily member 1
Gene namesi
Name:LTA
Synonyms:TNFB, TNFSF1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:42852 LTA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33By similarityAdd BLAST33
ChainiPRO_000003446234 – 204Lymphotoxin-alphaAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5WR07

Expressioni

Gene expression databases

BgeeiENSCAFG00000000515 Expressed in 1 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000000737

Structurei

3D structure databases

ProteinModelPortaliQ5WR07
SMRiQ5WR07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWT9 Eukaryota
ENOG410YQC4 LUCA
GeneTreeiENSGT00530000062992
HOGENOMiHOG000048729
HOVERGENiHBG012516
InParanoidiQ5WR07
KOiK05468
OMAiQYPFHVP
OrthoDBiEOG091G0HIG
TreeFamiTF332169

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002960 TNF_beta
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01236 TNFBETA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5WR07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPPGRLYLL RVRSAPVLLL LGLLLGLPPG AQGFPGVGIS PSAARTAYQH
60 70 80 90 100
PQKHFIQGTL KPAAHLIGDP SIQNSLRWRA NTDRAFLRHG FSLSNNSLLV
110 120 130 140 150
PTSGLYFVYS QVVFSGEGCF PKATPTPLYL AHEVQLFSSQ YPFHVPLLSA
160 170 180 190 200
QKSVCPGPQG PWVRSVYQGA VFLLTQGDQL STHTDGISHL LLSPSSVFFG

AFAL
Length:204
Mass (Da):22,033
Last modified:November 23, 2004 - v1
Checksum:iB1F88591328F80D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423389 Genomic DNA Translation: AAR27884.1
RefSeqiNP_001300778.1, NM_001313849.1
XP_848886.2, XM_843793.3

Genome annotation databases

EnsembliENSCAFT00000000802; ENSCAFP00000000737; ENSCAFG00000000515
GeneIDi607183
KEGGicfa:607183

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423389 Genomic DNA Translation: AAR27884.1
RefSeqiNP_001300778.1, NM_001313849.1
XP_848886.2, XM_843793.3

3D structure databases

ProteinModelPortaliQ5WR07
SMRiQ5WR07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000000737

Proteomic databases

PaxDbiQ5WR07

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000000802; ENSCAFP00000000737; ENSCAFG00000000515
GeneIDi607183
KEGGicfa:607183

Organism-specific databases

CTDi4049
VGNCiVGNC:42852 LTA

Phylogenomic databases

eggNOGiENOG410IWT9 Eukaryota
ENOG410YQC4 LUCA
GeneTreeiENSGT00530000062992
HOGENOMiHOG000048729
HOVERGENiHBG012516
InParanoidiQ5WR07
KOiK05468
OMAiQYPFHVP
OrthoDBiEOG091G0HIG
TreeFamiTF332169

Enzyme and pathway databases

ReactomeiR-CFA-5668541 TNFR2 non-canonical NF-kB pathway
R-CFA-5669034 TNFs bind their physiological receptors
R-CFA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Gene expression databases

BgeeiENSCAFG00000000515 Expressed in 1 organ(s), highest expression level in liver

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002960 TNF_beta
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01236 TNFBETA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNFB_CANLF
AccessioniPrimary (citable) accession number: Q5WR07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: September 12, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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