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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Binding sitei100NADUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Active sitei180Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADUniRule annotation6
Nucleotide bindingi123 – 125NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciBCLA66692:G1G25-2870-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:ABC2713
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134331 – 314Malate dehydrogenaseAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149PhosphoserineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5WEG2

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC2713

Structurei

3D structure databases

ProteinModelPortaliQ5WEG2
SMRiQ5WEG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiRQPGQTR
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q5WEG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIKRRKISV IGSGFTGATT ALMVAQKELG DVVLLDIPNM EGPTKGKALD
60 70 80 90 100
MLESTPVQGV DSTITGTSSY EDTKDSDVVV ITAGIARKPG MSRDDLVATN
110 120 130 140 150
AKIMKSVTKE VVKYSPNSYI IVLTNPADAM TYTVYKESGF PKNRVIGQSG
160 170 180 190 200
VLDTARFRTF VAQELNVSVE DVTGFVLGGH GDDMVPLIRY SAAGGVPLTK
210 220 230 240 250
LIAPERIEEI VERTRKGGGE IVGLLGNGSA YYAPAASLTQ MVEAILKDKK
260 270 280 290 300
RIIPTIAYLE GEYGQHDLYL GVPTILGGDG IEKVIELDLT EEEKAQLDKS
310
VQSVRNVMAA LPAE
Length:314
Mass (Da):33,597
Last modified:November 23, 2004 - v1
Checksum:iED99F51CA5F3F8D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA Translation: BAD65248.1
RefSeqiWP_011247556.1, NC_006582.1

Genome annotation databases

EnsemblBacteriaiBAD65248; BAD65248; ABC2713
GeneIDi34043297
KEGGibcl:ABC2713

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA Translation: BAD65248.1
RefSeqiWP_011247556.1, NC_006582.1

3D structure databases

ProteinModelPortaliQ5WEG2
SMRiQ5WEG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi66692.ABC2713

Proteomic databases

PRIDEiQ5WEG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD65248; BAD65248; ABC2713
GeneIDi34043297
KEGGibcl:ABC2713

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiRQPGQTR
OrthoDBiPOG091H02N6

Enzyme and pathway databases

BioCyciBCLA66692:G1G25-2870-MONOMER

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_BACSK
AccessioniPrimary (citable) accession number: Q5WEG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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